Advances in Diagnosis and Detection of Oral Diseases

Abstract

Medicine, particularly with respect to diagnostic decision-making, has seen remarkable advances in the last ten years. The art of diagnosis has become much more of a science. Basic science advances have moved from the laboratory into the hospital and radically changed the way a medical diagnosis is arrived at or confirmed. Dentistry, especially oral diagnosis, as yet has not been a significant part of this general medical advance. However, several examples demonstrate that this situation is starting to change. Oral conditions are beginning to be evaluated with greater precision and sophistication. This report reviews some recent advances in oral diagnostic research and suggests where they will carry dentistry over the next 25 years.

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References

Drayer, B. ; Jaszczak, R. ; Coleman, E. ; Storni, A. ; Greer, K. ; Petry, N. ; Lischko, M. ; and Flanagan, S. (1982): Muscarinic Cholinergic Receptor Binding: in vivo Depiction Using Single Photon Emission Computed Tomography and Radioiodinated Quinuclidinyl Benzilate, J Computer Assist Tomogr 6: 536-543.

Fine, D.H. and Mandel, I.D. (1986): Indicators of Periodontal Disease Activity: an Evaluation, J Clin Periodontol 13: 533-546.

Greenspan, J.S. ; Greenspan, D. ; Lannette, E.T. ; Abrams, D.J. ; Conant, M.A. ; Petersen, V. ; and Freese, U.K. (1985): Replication of Epstein-Barr Virus within the Epithelial Cells of Oral Hairy Leukoplakia, an AIDS-associated Lesion, N Engl J Med 313: 1564-1571.

Hargreaves, K.M. ; Dionne, R.A. ; Mueller, G.P. ; Gold-Stein, D.S. ; and Dubner, R. (1986): Naloxone, Fentanyl and Diazepam Modify Plasma Beta-Endorphin Levels During Surgery, Clin Pharmacol Ther 40: 165-171.

Hughes, C.V. ; Baum, B.J. ; Fox, P.C. ; Marmary, Y. ; Yeh, C.-K. ; and Sonies, B.C. (1987): Oral-Pharyngeal Dysphagia: a Common Sequela of Salivary Gland Dysfunction, Dysphagia 1: 173-177.

Jeffcoat, M.K. ; Williams, R.C. ; Kaplan, M.L. ; and Gold-Haber, P. (1985): Bone-seeking Radiopharmaceutical Uptake as an Indicator of Active Alveolar Bone Loss in Untreated and Surgically Treated Teeth in Beagle Dogs, J Periodont Res 20: 301-306.

King, C.R. ; Kraus, M.H. ; and Aaronson, S.A. (1985): Amplification of a Novel v-erb B-related Gene in a Human Mammary Carcinoma, Science 229: 974-976.

Semba, K. ; Kamata, N. ; Toyoshima, K. ; and Yamamoto, T. (1985): A v-erb B-related Protooncogene, c-erb B-2, is Distinct from the c-erb B-1/Epidermal Growth Factor-Receptor Gene and is Amplified in a Human Salivary Gland Adenocarcinoma, Proc Natl Acad Sci USA 82: 6497-6501.

Shawker, T.H. ; Sonies, B. ; Stone, M. ; and Baum, B.J. (1983): Real-time Ultrasound Visualization of Tongue Movement During Swallowing, J Clin Ultrasound 11: 485-490.

10.

Skaleric, U. ; Dolinšek, J. ; Stepisnik, J. ; Cevc, P. ; and Schara, M. (1987): NMR Imaging in Dentistry: Relaxation and Diffusion Studies, Adv Dent Res 1: 85-87.

11.

Van Dop, C. and Bourne, H.R. (1983): Pseudohypoparathyroidism, Ann Rev Med 34: 259-266.

12.

Wang, C.-Y. and Huang, L. (1987): pH Sensitive Immunoliposomes Mediate Target-cell-specific Delivery and Controlled Expression of a Foreign Gene in Mouse, Proc Natl Acad Sci USA 84: 7851-7855.