The authors reviewed the use of clozapine in eight patients over age 65 years with treatment-resistant psychoses. Six patients improved. Two patients became more confused. The authors suggest that clozapine be considered in treating elderly psychotic patients, and that its use need not be restricted to schizophrenic patients.
2. Ganzini L, Heintz R, Hoffman WF, et al: Acute extrapyramidal syndromes in neuroleptic-treated elders: A pilot study. J Geriatr Psychiatry Neurol1991; 4:222–225.
3.
3. Scholz E, Dichgans J: Treatment of drug-induced exogenous psychosis in parkinsonism with clozapine and fluperlapine. Eur Arch Psychiatry Neurol Sci1985; 235:60–64.
4.
4. Friedman JH, Lannon MC: Clozapine in the treatment of psychosis in Parkinson's disease. Neurology1989; 39:1219–1221.
5.
5. Kahn N, Freeman A, Juncos JL, et al: Clozapine is beneficial for psychosis in Parkinson's disease. Neurology1991; 41:1699–1701.
6.
6. Parsa MA, Ramirez LF, Loula EC, Meltzer HY: Effect of clozapine on psychotic depression and parkinsonism. J Clin Psychopharmacol1991; 11:330–331.
7.
7. McElroy SL, Keck PE, Pope HG: Sodium valproate: Its use in primary psychiatric disorders. J Clin Psychopharmacol1987; 7:16–24.
8.
8. Naber D, Leppig M, Grohmann R, Hippius H: Efficacy and adverse effects of clozapine in the treatment of schizophrenia and tardive dyskinesia—a retrospective study of 387 patients. Psychopharmacology1989; 99:S73–S76.
9.
9. Salzman C: Psychotropic drug dosages and drug interactions, in Salzman C (ed): Clinical Geriatric Psychopharmacology. New York, McGraw-Hill, 1984, pp 201–215.
