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Abstract

The shape and thickness of the third ventricles were studied with magnetic resonance imaging in 46 patients under evaluation for memory impairment. We compared this population with 23 subjects imaged for other reasons. The study group consisted of patients with diagnoses of probable dementia of the Alzheimer's type (DAT; 35.6%), multi-infarct dementia (MID; 22.2%), depression (8.9%), alcoholic dementia (6.7%), other dementias (OD; 13.2%) and no dementia (6.7%). Within the study group, there were no significant differences across diagnostic categories for duration of symptoms or level of education. Patients with DAT were, however, more impaired than others (Mini-Mental State Examination scores: DAT 14.6 [±8.2] versus MID 17.4 [±6.2] versus OD 21.2 [±6.4]). Demented subjects were more likely than nondemented individuals to have a convex third ventricle and greater wall separation. The results suggest that the shape of the third ventricle may correlate with dementia. Possibly, the dorsal medial nucleus of the thalamus is involved in the dementia.

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References

1. Graff-Radford N , Damasio H , Yamada T , et al: Nonhemorrhagic thalamic infarction: Clinical, neuropsychological and electrophysiological findings in four anatomical groups defined by computed tomography. Brain 1985; 108:485–516.

2. Graff-Radford N , Schelper R , Ilinski I , Damasio H : Computed tomographic and postmortem study of a nonhemorrhagic thalamic infarction. Arch Neurol 1985; 42:761–763.

3. Akiguchi I , Ino T , Nabatame H , et al: Acute-onset amnestic syndrome with localized infarct on the dominant side—Comparison between anteromedial thalamic lesion and posterior cerebral artery territory lesion. Jpn J Med 1987; 26:15–20.

4. Bogousslavsky J , Regli F : Transient global amnesia and stroke. Eur Neurol 1988; 28:106–110.

5. Bogousslavsky J , Regli F , Assal G : The syndrome of unilateral tuberothalamic artery territory infarction. Stroke 1986; 17:434–441.

6. Cambier J , Graveleau P : Thalamic syndromes, in Vinken PJ , Bruyn GW , Klawans HL , Frederiks JAM (eds): Handbook of Clinical Neurology. Amsterdam, Elsevier, 1985, pp 87–98.

7. Castaigne P , Lhermitte F , Buge A , et al: Paramedian thalamic and midbrain infarcts: Clinical and neuropathological study. Ann Neurol 1981; 10:127–148.

8. Cohen J , Gelfer C , Sweet R : Thalamic infarction producing aphasia. Mt Sinai J Med 1980; 47:395–404.

9. Cummings J , Benson D : Subcortical dementia: Review of an emerging concept. Arch Neurol 1984; 41:874–879.

10.

10. Fensore C , Lazzarino LG , Nappo A , Nicoai A : Language and memory disturbances from mesencephalothalamic infarcts. A clinical and computed tomography study. Eur Neurol 1988; 28:51–56.

11.

11. Coyne AC , Meade HM , Petrone ME , et al: The diagnosis of dementia: Demographic characteristics. Gerontologist 1990; 30:339–344.

12.

12. Folstein M , Folstein S , McHugh P : Mini-Mental State: A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12:189–198.

13.

13. Hachinski V , Lassen N , Marshall J : Multi-infarct dementia: A cause of mental deterioration in the elderly. Lancet 1974; 2:207–210.

14.

14. Diagnostic and Statistical Manual of Mental Disorders, 3rd ed. Washington, DC, American Psychiatric Association, 1980.

15.

15. McKhann G , Drachman D , Folstein M , et al: Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34:939–944.

16.

16. Lee E , Wang J-Z , Mezrich R : Variation of the lateral ventricular volume during cardiac cycle observed by magnetic resonance imaging. Am J Neuroradiol 1989; 27:416–422.

17.

17. Wang J-Z , Mezrich R , Sebok D : Image processing on Macintosh II: A practical edge detection algorithm for biomedical measurement. Comput Med Imaging Graph 1990; 14:163–171.

18.

18. Brodal A : Neurological Anatomy in Relation to Clinical Medicine. New York, Oxford University Press, 1981, pp 95–97.

19.

19. Roberts E : Beyond measurement: The pattern is the thing. Neurobiol Aging 1988; 9:97–100.

20.

20. Crick F : Function of the thalamic reticular complex: The searchlight hypothesis. Proc Natl Acad Sci USA 1984; 81:4586–4590.

21.

21. Vallar G , Perani D : The anatomy of unilateral neglect after right hemisphere stroke lesions. A clinical/CT-scan correlation study in man. Neuropsychologia 1986; 24:609–622.

22.

22. Moossy J , Martinez AJ , Hanin I , et al: Thalamic and subcortical gliosis with dementia. Arch Neurol 1987; 44:510–513.

23.

23. Kritchevsky M , Graff-Radford NR , Damasio A : Normal memory after damage to medial thalamus. Arch Neurol 1987; 44:959–962.

24.

24. Rafal RD , Posner MI : Deficits in human spatial attention following thalamic lesions. Proc Natl Acad Sci USA 1987; 84:7349–7353.

25.

25. Bogousslavsky J , Ferrazzini M , Regli F , et al: Manic delirium and frontal-like syndrome with paramedian infarction of the right thalamus. J Neurol Neurosurg Psychiatry 1988; 51:116–119.

Convex Third Ventricle: A Possible Sign for Dementia Using MRI

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