A group of 136 elderly subjects were administered a comprehensive neuropsychological test battery, which was readministered 2 years later. Among the 136 elderly subjects, 86 were assigned a diagnosis of probable Alzheimer's disease. An additional 33 young subjects were administered the assessment battery at baseline only. The normal elderly group exhibited no decline in cognitive test performance over the 2-year follow-up interval. Subjects with mild cognitive impairment, however, were as likely to deteriorate between baseline and follow-up as the more severely impaired subjects. The tests that exhibited longitudinal decline in the Alzheimer's disease patients constituted a subset of the tests that revealed cross-sectional deficits relative to the normal elderly. Differences in baseline cognitive test performance and in rate of cognitive deterioration were examined in relatively young versus relatively old Alzheimer's disease patients. Potential psychometric predictors of cognitive decline in the normal elderly were identified.
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References
1.
1. Flicker C, Ferris SH, Crook T, et al: Cognitive decline in advanced age: Future directions for the psychometric differentiation of normal and pathological age changes in cognitive function. Dev Neuropsychol1986; 2:309–322.
2.
2. Schaie KW: Intelligence and problem solving, in Birren JE, Sloane RB (eds): Handbook of Mental Health and Aging. Englewood Cliffs, NJ, Prentice-Hall, 1980, pp 262–284.
3.
3. Siegler IC, Botwinick J: A long-term longitudinal study of intellectual ability of older adults: The matter of selective subject attrition. J Gerontol1979; 34:242–245.
4.
4. Rinn WE: Mental decline in normal aging: A review. J Geriatr Psychiatry Neurol1988; 1:144–158.
5.
5. Seltzer B, Sherwin I: A comparison of clinical features in early- and late-onset primary degenerative dementia. Arch Neurol1983; 40:143–146.
6.
6. Knesevich JW, Toro FR, Morris JC, LaBarge E: Aphasia, family history, and the longitudinal course of senile dementia of the Alzheimer type. Psychiatr Res1985; 14:255–263.
7.
7. Reisberg B, Ferris SH, de Leon MJ, Crook T: The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry1982; 139:1136–1139.
8.
8. Hamilton M: Development of a rating scale for primary depression illness. Br J Soc Clin Psychol1967; 6:278–296.
9.
9. Hachinski VC, Iliff LD, Zilhka E, et al: Cerebral blood flow in dementia. Arch Neurol1975; 32:632–637.
10.
10. Rosen WG, Terry RD, Fuld PA, et al: Pathological verification of ischemia score in differentiation of dementias. Ann Neurol1980; 7:486–488.
11.
11. Van Gelder P, Todd J, Tsui WH: Data acquisition software for high data rate experiments. Behav Res Methods Instrum1979; 11:192–198.
12.
12. Tsui WH, Van Gelder P: A general-purpose data extraction language. Behav Res Methods Instrum1979; 11:199–204.
13.
13. Wechsler D: Manual for the Wechsler Adult Intelligence Scale. New York, Psychological Corporation, 1955.
14.
14. Gilbert JG, Levee RF, Catalano FL: A preliminary report on a new memory scale. Percept Mot Skills1968; 27:277–278.
15.
15. McCarthy M, Ferris SH, Clark E, Crook T: Acquisition and retention of categorized material in normal aging and senile dementia. Exp Aging Res1981; 7:127–135.
16.
16. Flicker C, Bartus RT, Crook T, Ferris SH: Effects of aging and dementia upon recent visuospatial memory. Neurobiol Aging1984; 5:275–283.
17.
17. Bartus RT, Fleming D, Johnson HR: Aging in the rhesus monkey: Debilitating effects on short-term memory. J Gerontol1978; 33:858–871.
18.
18. Crook T, Ferris SH, McCarthy M: The misplaced-objects task: A brief test for memory dysfunction in the aged. J Am Geriatr Soc1979; 27:284–287.
19.
19. Flicker C, Ferris SH, Crook T, Bartus RT: A visual recognition memory test for the assessment of cognitive function in aging and dementia. Exp Aging Res1987; 13:127–132.
20.
20. Ferris SH, Crook T, Clark E, et al: Facial recognition memory deficits in normal aging and senile dementia. J Gerontol1980; 35:707–714.
21.
21. Flicker C, Ferris SH, Crook T, Bartus RT: Age differences in the vulnerability of facial recognition memory to proactive interference. Exp Aging Res1989; 15:189–194.
23. Flicker C, Ferris SH, Crook T, Bartus RT: Implications of memory and language dysfunction in the naming deficit of senile dementia. Brain Lang1987; 31:187–200.
24.
24. Squire LR: Remote memory as affected by aging. Neuropsychologia1974; 12:429–435.
25.
25. Kaplan E, Goodglass H, Weintraub S: Boston Naming Test. Philadelphia, Lea & Febiger, 1983.
26.
26. Snodgrass JG, Vanderwart M: A standardized set of 260 pictures: Norms for name agreement, image agreement, familiarity, and visual complexity. J Exp Psychol Hum Learning Memory1980; 6:174–215.
27.
27. Flicker C, Ferris SH, Crook T, Bartus RT: The effects of aging and dementia on concept formation as measured on an object-sorting task. Dev Neuropsychol1986; 2:65–72.
28.
28. Money J, Alexander D, Walker HT: A Standardized Road-Map Test of Direction Sense. Baltimore, Johns Hopkins University Press, 1965.
29.
29. Lehman HE, Ban TA: Psychometric tests in evaluation of brain pathology, responsive to drugs. Geriatrics1970; 25:142–147.
30.
30. Flicker C, Serby M, Ferris SH: Scopolamine effects on memory, language, visuospatial praxis, and psychomotor speed. Psychopharmacology1990; 100:243–250.
31.
31. Flicker C, Ferris SH, Crook T, et al: Equivalent spatial rotation deficits in normal aging and Alzheimer's disease. J Clin Exp Neuropsychol1988; 10:387–399.
32.
32. Flicker C, Ferris SH, Reisberg B: Mild cognitive impairment in the elderly: Predictors of dementia. Neurology1991; 41:1006–1009.
33.
33. Craik FIM: Age differences in human memory, in Birren JE, Schaie KW (eds): Handbook of the Psychology of Aging. New York, Van Nostrand Reinhold, 1977.
34.
34. Welford AT: Motor performance, in Birren JE, Schaie KW (eds): Handbook of the Psychology of Aging. New York, Van Nostrand Reinhold, 1977.
35.
35. Ferris SH, Crook T, Sathananthan G, Gershon S: Reaction time as a diagnostic measure of cognitive impairment in senility. J Am Geriatr Soc1976; 24:529–533.
36.
36. Storandt M, Botwinick J, Danziger WL: Longitudinal changes: Patients with mild SDAT and matched healthy controls, in Poon LW (ed): Handbook for Clinical Memory Assessment of Older Adults. Washington, DC, American Psychological Association, 1986, pp 277–284.
37.
37. Rebok G, Brandt J, Folstein M: Longitudinal cognitive decline in patients with Alzheimer's disease. J Geriatr Psychiatry Neurol1990; 3:91–97.
38.
38. Schaie KW: The Seattle longitudinal study: A 21-year exploration of psychometric intelligence in adulthood, in Schaie KW (ed): Longitudinal Studies of Adult Psychological Development. New York, Guilford Press, 1983.
39.
39. Sim A, Sussman I: Alzheimer's disease: Its natural history and differential diagnosis. J Nerv Ment Dis1962; 135:489–499.
40.
40. Neary D, Snowden JS, Bowen DM, et al: Neuropsychological syndromes in presenile dementia due to cerebral atrophy. J Neurol Neurosurg Psychiatry1986; 49:163–174.
41.
41. Fozard JL: Psychology of aging—normal and pathological age differences in memory, in Brocklehurst JC (ed): Textbook of Geriatric Medicine and Gerontology. Edinburgh, Churchill Livingstone, 1985.
42.
42. Randt CT, Brown ER, Osborne DP: A memory test for longitudinal measurement of mild to moderate deficits. Clin Neuropsychol1980; 2:184–194.
43.
43. Pirozzolo FJ, Hansch EC: Oculomotor reaction time in dementia reflects degree of cerebral dysfunction. Science1981; 214:349–351.
44.
44. Muramoto O: Selective reminding in normal and demented aged people: Auditory verbal versus visual spatial task. Cortex1984; 20:461–478.
45.
45. Benton AL: Revised Visual Retention Test. New York, Psychological Corporation, 1974.
46.
46. Hart RP, Kwentus JA, Wade JB, Hamer RM: Digit symbol performance in mild dementia and depression. J Consult Clin Psychol1987; 55:236–238.
47.
47. Schonfield D, Robertson BA: Memory storage and aging. Can J Psychol1966; 20:228–236.
48.
48. Branconnier RJ, Cole JO, Spera KF, DeVitt DR: Recall and recognition as diagnostic indices of malignant memory loss in senile dementia: a Bayesian analysis. Exp Aging Res1982; 8:189–193.
49.
49. McKhann G, Drachman D, Folstein M, et al: Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology1984; 34:939–944.
50.
50. Berg L, Danziger WL, Storandt M, et al: Predictive features in mild senile dementia of the Alzheimer type. Neurology1984; 34:563–569.
