Plasma β-Amyloid in Mild Behavioural Impairment – Neuropsychiatric Symptoms on the Alzheimer’s Continuum

Abstract

Introduction:

Simple markers are required to recognize older adults at higher risk for neurodegenerative disease. Mild behavioural impairment (MBI) and plasma β-amyloid (Aβ) have been independently implicated in the development of incident cognitive decline and dementia. Here we studied the associations between MBI and plasma Aβ₄₂/Aβ₄₀.

Methods:

Participants with normal cognition (n = 86) or mild cognitive impairment (n = 53) were selected from the Alzheimer’s Disease Neuroimaging Initiative. MBI scores were derived from Neuropsychiatric Inventory items. Plasma Aβ₄₂/Aβ₄₀ ratios were assayed using mass spectrometry. Linear regressions were fitted to assess the association between MBI total score as well as MBI domain scores with plasma Aβ₄₂/Aβ₄₀.

Results:

Lower plasma Aβ₄₂/Aβ₄₀ was associated with higher MBI total score (p = 0.04) and greater affective dysregulation (p = 0.04), but not with impaired drive/motivation (p = 0.095) or impulse dyscontrol (p = 0.29) MBI domains.

Conclusion:

In persons with normal cognition or mild cognitive impairment, MBI was associated with low plasma Aβ₄₂/Aβ₄₀. Incorporating MBI into case detection may help capture preclinical and prodromal Alzheimer’s disease.