Neural Correlates of Activities of Daily Living in Frontotemporal Dementia

Abstract

Background:

Little research to date has investigated neural correlates of functional disability in frontotemporal dementia (FTD).

Methods:

Activities of daily living (ADL) were covaried against gray matter atrophy regions via Voxel-based morphometry in FTD (n = 52) and contrasted against a dementia control Alzheimer disease (AD) group (n = 20) and healthy age-matched controls (n = 18).

Results:

Both patient groups had similar ADL scores. However, FTD and AD differed on the gray matter atrophy areas associated with ADL scores. The FTD showed involvement of prefrontal and thalamus regions while AD showed widespread temporal, parietal, frontal, and caudate atrophy correlating with ADL dysfunction. Importantly, only the left superior frontal gyrus was implicated in ADL dysfunction for both FTD and AD.

Conclusions:

Differences in underlying neural correlates of ADL impairment have important clinical implications as these differences should be taken into account when interventions are planned. Dementia subtypes might require specifically tailored interventions for functional disability.

Keywords

activities of daily living functional disability frontotemporal dementia Alzheimer disease disability assessment for dementia voxel-based morphometry

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References

Mioshi

Kipps

Dawson

Mitchell

Graham

Hodges

. Activities of daily living in frontotemporal dementia and Alzheimer disease. Neurology. 2007;68(24):2077–2084.

Wicklund

Johnson

Rademaker

Weitner

Weintraub

. Profiles of decline in activities of daily living in non-Alzheimer dementia. Alzheimer Dis Assoc Disord. 2007;21(1):8–13.

Chow

Izenberg

Binns

Magnetic resonance imaging in frontotemporal dementia shows subcortical atrophy. Dement Geriatr Cogn Disord. 2008;26(1):79–88.

Nadkarni

Levy-Cooperman

Black

. Functional correlates of instrumental activities of daily living in mild Alzheimer's disease. Neurobiol Aging. 2012;33(1):53–60.

Vidoni

Honea

Burns

. Neural correlates of impaired functional independence in early Alzheimer's disease. J Alzheimer's Dis. 2010;19(2):517–527.

Melrose

Ettenhofer

Harwood

Cerebral metabolism, cognition, and functional abilities in Alzheimer disease. J Geriatr Psychiatry Neurol. 2011;24(3):127–134.

Cahn-Weiner

Farias

Julian

Cognitive and neuroimaging predictors of instrumental activities of daily living. J Int Neuropsychol Soc. 2007;13(5):747–757.

Rascovsky

Hodges

Knopman

Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain. 2011;134(Pt 9):2456–2477.

Neary

Snowden

Gustafson

Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology. 1998;51(6):1546–1554.

10.

McKhann

Drachman

Folstein

Katzman

Price

Stadlan

. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's Disease. Neurology. 1984;34(7):939–944.

11.

Gorno-Tempini

Dronkers

Rankin

Cognition and anatomy in three variants of primary progressive aphasia. Ann Neurol. 2004;55(3):335–346.

12.

Gelinas

Gauthier

McIntyre

Gauthier

. Development of a functional measure for persons with Alzheimer's disease: the disability assessment for dementia. Am J Occup Ther. 1999;53(5):471–481.

13.

Mioshi

Dawson

Mitchell

Arnold

Hodges

. The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening. Int J Geriatr Psychiatry. 2006;21(11):1078–1085.

14.

Ashburner

Friston

. Voxel-based morphometry--the methods. Neuroimage. 2000;11(6 Pt 1):805–821.

15.

Good

Johnsrude

Ashburner

Henson

Friston

Frackowiak

. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage. 2001;14(1 Pt 1):21–36.

16.

Smith

Jenkinson

Woolrich

Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage. 2004;23(suppl 1):S208–S219.

17.

Zhang

Brady

Smith

. Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging. 2001;20(1):45–57.

18.

Andersson

JLR

Jenkinson

Smith

. Non-linear registration, aka Spatial normalisation; 2007.

19.

Andersson

JLR

Jenkinson

Smith

Non-linear optimisation; 2007.

20.

Rueckert

Sonoda

Hayes

Hill

Leach

Hawkes

. Nonrigid registration using free-form deformations: application to breast MR images. IEEE Trans Med Imaging. 1999;18(8):712–721.

21.

Smith

Nichols

. Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage. 2009;44(1):83–98.

22.

Rushworth

Noonan

Boorman

Walton

Behrens

. Frontal cortex and reward-guided learning and decision-making. Neuron. 2011;70(6):1054–1069.

23.

Hornberger

Geng

Hodges

. Convergent grey and white matter evidence of orbitofrontal cortex changes related to disinhibition in behavioural variant frontotemporal dementia. Brain. 2011;134(Pt 9):2502–2512.

24.

Hillary

Genova

Chiaravalloti

Rypma

DeLuca

. Prefrontal modulation of working memory performance in brain injury and disease. Hum Brain Mapp. 2006;27(11):837–847.

25.

Alexander

Brown

. Medial prefrontal cortex as an action-outcome predictor. Nature neuroscience. 2011;14(10):1338–1344.

26.

Rowe

Hughes

Nimmo-Smith

. Action selection: a race model for selected and non-selected actions distinguishes the contribution of premotor and prefrontal areas. Neuroimage. 2010;51(2):888–896.

27.

Behrens

Johansen-Berg

Woolrich

Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nature Neurosci. 2003;6(7):750–757.

28.

Klein

Rushworth

Behrens

Topography of connections between human prefrontal cortex and mediodorsal thalamus studied with diffusion tractography. Neuroimage. 2010;51(2):555–564.

29.

Zamboni

Huey

Krueger

Nichelli

Grafman

Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates. Neurology. 2008;71(10):736–742.

30.

Nyatsanza

Shetty

Gregory

Lough

Dawson

Hodges

. A study of stereotypic behaviours in Alzheimer's disease and frontal and temporal variant frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2003;74(10):1398–1402.

31.

Rosen

Allison

Schauer

Gorno-Tempini

Weiner

Miller

. Neuroanatomical correlates of behavioural disorders in dementia. Brain. 2005;128(Pt 11):2612–2625.

32.

Kertesz

Davidson

McCabe

Munoz

. Behavioral quantitation is more sensitive than cognitive testing in frontotemporal dementia. Alzheimer Dis Assoc Disord. 2003;17(4):223–229.

33.

Bozeat

Gregory

Ralph

Hodges

. Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer's disease? J Neurol Neurosurg Psychiatry. 2000;69(2):178–186.

34.

Hanakawa

. Rostral premotor cortex as a gateway between motor and cognitive networks. Neurosci Res. 2011;70(2):144–154.

35.

Majdandzic

Grol

van Schie

Verhagen

Toni

Bekkering

. The role of immediate and final goals in action planning: an fMRI study. Neuroimage. 2007;37(2):589–598.

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