Objective: To evaluate the Cognitive Linguistic Quick Test (CLQT) as a cognitive screening tool in Parkinson disease (PD). Methods: A total of 93 patients with PD were evaluated with the Mini-Mental State Examination (MMSE) and the CLQT. The CLQT provides separate ratings for 5 cognitive domains. Descriptive statistics, correlations between the tests, and diagnostic value for dementia were analyzed. Results: Cognitive Linguistic Quick Test correlated well with MMSE. Diagnostic values for dementia were similar for the 2 instruments. Unlike the MMSE, the CLQT also provided domain-specific information on cognitive deficits. Cognitive domains were differentially affected between and within the demented and nondemented patient groups with PD: memory was the weakest domain in the demented group and attention in the nondemented. Conclusions: The CLQT is a valuable instrument in assessing cognitive dysfunction in PD. The CLQT is superior to the MMSE as it also provides cognitive domain-specific information.
Brown RG, Marsden CDCognitive function in Parkinson’s disease: from description to theory . Trends Neurosci. 1990;13(1):21-29.
2.
Levin BE, Tomer R., Rey GJCognitive impairments in Parkinson’s disease. Neurol Clin. 1992;10(2):471-485.
3.
Bosboom JLW , Stoffers D., Wolters ECCognitive dysfunction and dementia in Parkinson’s disease. J Neural Transm. 2004;111(10-11):1303-1315.
4.
Lees AJParkinson’s disease and dementia. Lancet. 1985;1(8419):43-44.
5.
Mayeux R., Stern Y., Rosenstein R., et al. An estimate of the prevalence of dementia in idiopathic Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1988 ;45(3):260-262.
6.
Girotti F., Solvieri P., Carella F., et al. Dementia and cognitive impairment in Parkinson’s disease . J Neurol Neurosurg Psychiatry. 1988;51(12):1498-1502.
7.
Ebmeier KP, Calder SA, Crawford JR, Stewart L., Besson JA, Mutch WJClinical features predicting dementia in idiopathic Parkinson’s disease: a follow-up study. Neurology. 1990 ;40(8):1222-1224.
8.
Giladi N., Treves TA, Paleacu D., et al. Risk factors for dementia, depression and psychosis in long-standing Parkinson’s disease. J Neural Transm. 2000;107(1):59-71.
9.
Aarsland D., Andersen K., Larsen JP, Lolk A., Nielsen H., Kragh-Sorensen P.Risk of dementia in Parkinson’s disease: a community-based, prospective study. Neurology. 2001;56(6):730-736.
10.
Hobson P., Meara J.Risk and incidence of dementia in a cohort of older subjects with Parkinson’s disease in the United Kingdom. Mov Disord . 2004;19(9):1043-1049.
11.
Parashos SA , Maraganore DM, O’Brien PC, Rocca WAMedical services utilization and prognosis in Parkinson’s disease: a population-based study. Mayo Clin Proc.2002 ;77(9):918-925.
12.
Wielinski CL , Erickson-Davis C., Wichmann R., Walde-Douglas M., Parashos SAFalls and injuries resulting from falls among patients with Parkinson’s disease and other parkinsonian syndromes . Mov Disord.2005; 20(4):410-415.
13.
Devos H., Vandenberghe W., Nieuwboer A., Tant M., Baten G., De Weerdt W.Predictors of fitness to drive in people with Parkinson disease. Neurology. 2007; 69(14):1434-1441.
14.
Bronnick K. , Ehrt U., Emre M., et al. Attentional deficits affect activities of daily living in dementia associated with Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2006;77(10):1136-1142.
15.
Nieuwboer A. , De Weerdt W., Dom R., Bogaerts K.Prediction of outcome of physiotherapy in advanced Parkinson’s disease. Clin Rehabil. 2002; 16(8): 886-893.
16.
Helm-Estabrooks N.Cognitive Linguistic Quick Test (CLQT): Examiner’s Manual. The Psychological Corporation, San Antonio, TX; 2001.
17.
Folstein MF , Folstein SE, McHugh PR ‘‘ Mini-Mental State’’: a practical method for grading the cognitive state of patients for the clinician . J Psychiatr Res. 1975 ;12(3): 189-198.
18.
Gelb DJ, Oliver E., Gilman S.Diagnostic criteria for Parkinson Disease. Arch Neurol . 1999;56(1):33-39.
19.
Tangalos EG , Smith GE, Ivnik RJ, et al. The Mini-Mental State Examination in general medical practice: clinical utility and acceptance . Mayo Clin Proc. 1996; 71(9):829-837.
20.
Hoehn MM, Yahr MDParkinsonism: onset, progression, and mortality. Neurology . 1967;17(5):427-442.
21.
Beard CM, Kokmen E., O’Brien PC, Kurland LTThe prevalence of dementia is changing over time in Rochester, Minnesota . Neurology. 1995;45(1):75-79.
22.
Stam CJ, Visser SL, Op de Coul AA, et al. Disturbed frontal regulation of attention in Parkinson’s disease. Brain. 1993;116(pt 5):1139-1158.
Hocherman S. , Moont R., Schwartz M.Recruitment of attentional resources during visuomotor tracking: effects of Parkinson’s disease and age. Brain Res Cogn Brain Res. 2004;21(1):77-86.
25.
Owen AM, Doyon J., Dagher A., Sadikot A., Evans ACAbnormal basal ganglia outflow in Parkinson’s disease identified with PET. Implications for higher cortical functions. Brain . 1998;121(pt 5):949-965.
26.
Brück A., Kurki T., Kaasinen V., Vahlberg T., Rinne JOHippocampal and prefrontal atrophy in patients with early non-demented Parkinson’s disease is related to cognitive impairment. J Neurol Neurosurg Psychiatry . 2004;75(10):1467-1469.
27.
Owen AMCognitive dysfunction in Parkinson’s disease: the role of frontostriatal circuitry. Neuroscientist. 2004; 10(6):525-537.
28.
Cooper JA, Sagar HJ, Jordan N., Harvey NS, Sullivan EVCognitive impairment in early, untreated Parkinson’s disease and its relationship to motor disability. Brain. 1991 ;114(pt 5):2095-2122.
29.
Lange KW, Robbins TW, Marsden CD, James M., Owen AM, Paul GMl-Dopa withdrawal in Parkinson’s disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction. Psychopharmacology. 1992;107(2-3):394-404.
30.
Levy G., Jacobs DM, Tang MX, et al. Memory and executive function impairment predict dementia in Parkinson’s disease. Mov Disorders. 2002;17(6):1221-1226.
31.
Henry JD, Crawford JRVerbal fluency deficits in Parkinson’s disease: a meta-analysis . J Int Neuropsychol Soc. 2004;10(4):608-622.
32.
Brown RG, Marsden CDHow common is dementia in Parkinson’s disease? Lancet . 1984;1(8414):71-83.
33.
Braak H., Ghebremedhin E., Rub U., Bratzke H., Del Tredici K.Stages in the development of Parkinson’s disease-related pathology . Cell Tissue Res. 2004; 318(1):121-134.
34.
Tam CW, Burton EJ, McKeith IG, Burn DJ, O’Brien JTTemporal lobe atrophy on MRI in Parkinson disease with dementia: a comparison with Alzheimer disease and dementia with Lewy bodies. Neurology . 2005; 64(5): 861-865.
