Although quetiapine is the antipsychotic of choice for the psychosis associated with Parkinson's disease (PD) and often is also helpful for sleep, we report two cases of quetiapine-induced extrapyramidal side effects. The patients described were unusual in their frailty and severity of illness and may not represent the majority of patients with PD. (J Geriatr Psychiatry Neurol 2001; 14:99-100).
Get full access to this article
View all access options for this article.
References
1.
Parkinson's disease: one illness or many syndromes [editorial] ? Lancet1992; 339:1263-1264.
2.
Inzelberg R. , Kipervasser S., Korczyn ADAuditory hallucinations in Parkinson's disease . J Neurol Neurosurg Psychiatry1998; 64:533-535.
3.
Richelson E.Receptor pharmacology of neuroleptics: relation to clinical effects. J Clin Psychiatry1999 ; 60(Suppl 10):5-14.
4.
Targum SD, Abbott JLEfficacy of quetiapine in Parkinson's patients with psychosis. J Clin Psychopharmacol2000; 20:54-60.
5.
Parsa MA, Bastani B.Quetiapine (seroquel) in the treatment of psychosis in patients with Parkinson's disease. J Neuropsychiatry Clin Neurosci1998 ; 10:216-219.
6.
Small JG, Hirsch SR, Arvanitis LA, et al. Quetiapine in patients with schizophrenia. A high- and low-dose double-blind comparison with placebo. Seroquel study group. Arch Gen Psychiatry1997; 54:549-557.
7.
Casey DE 'Seroquel' (quetiapine): preclinical and clinical findings of a new atypical antipsychotic. Exp Opin Invest Drugs1996; 5:939-957.
8.
Yeung PP, Tariot PN, Schneider LS, et al. Quetiapine for elderly patients with psychotic disorders. Psychiatr Ann2000; 30:197-201.