This systematic review synthesizes factors related to nicotine replacement therapy (NRT) use among adolescents seeking to quit smoking, using the social–ecological model as a guiding framework.
Data Source:
Searches of PubMED, ProQuest, EBSCOhost, and ERIC were conducted in July 2016.
Study Inclusion and Exclusion Criteria:
Original studies of cigarette smokers younger than 18 years that discussed NRT were included.
Data Extraction:
Two reviewers individually extracted study purpose, sample, design, and results.
Data Synthesis:
Factors were categorized by social–ecological model level and summarized.
Results:
A total of 103 907 articles were identified during initial search. After narrowing to peer-reviewed articles in English and eliminating reviews and adult-only studies, we reviewed 51 articles. These 51 articles identified factors from studies at each level of the social–ecological model: intrapersonal (k = 20), interpersonal (k = 2), organizational (k = 7), community (k = 11), and public policy (k = 14).
Conclusion:
Findings provide insight into the applicability of NRT for adolescent smoking cessation, and factors by social–ecological model level highlight areas for additional research. Future adolescent NRT studies should assess factors at the interpersonal, organizational, and community levels, as well as the interactions between levels.
United States, Public Health Services, Office of the Surgeon General, National Center for Chronic Disease Prevention and Health Promotion (US), Office on Smoking and Health. The Health Consequences of Smoking-50 Years of Progress: A Report of the Surgeon General, 2014. Rockville, MD: US Department of Health and Human Services, Public Health Service, Office of the Surgeon General; 2014.
2.
United States, Public Health Service, Office of the Surgeon General, National Center for Chronic Disease Prevention and Health Promotion (US), Office on Smoking and Health. Preventing Tobacco Use among Youth and Young Adults: A Report of the Surgeon General. Rockville, MD: US Department of Health and Human Services, Public Health Service, Office of the Surgeon General; 2012.
3.
FioreM, ed. Treating Tobacco Use and Dependence: 2008 Update. Rockville, MD: US Department of Health and Human Services, Public Health Service; 2008.
RoblesGISingh-FrancoDGhinHL. A review of the efficacy of smoking-cessation pharmacotherapies in nonwhite populations. Clin Ther. 2008;30(5):800–812. doi:10.1016/j.clinthera.2008.05.010.
6.
SteadLFPereraRBullenC. Nicotine replacement therapy for smoking cessation. In: The CochraneCollaboration, ed. Cochrane Database of Systematic Reviews. Chichester, UK: John Wiley & Sons, Ltd; 2012. doi:10.1002/14651858.CD000146.pub4. Accessed September 14, 2016.
BaileySRCrewEERiskeECAmmermanSRobinsonTNKillenJD. Efficacy and tolerability of pharmacotherapies to aid smoking cessation in adolescents. Pediatr Drugs. 2012;14(2):91–108. doi:10.2165/11594370-000000000-00000.
9.
KimYMyungSKJeonYJ. Effectiveness of pharmacologic therapy for smoking cessation in adolescent smokers: meta-analysis of randomized controlled trials. Am J Health Syst Pharm. 2011;68(3):219–226. doi:10.2146/ajhp100296.
10.
KingJLPomeranzJLMertenJW. A systematic review and meta-evaluation of adolescent smoking cessation interventions that utilized nicotine replacement therapy. Addict Behav. 2016;52:39–45. doi:10.1016/j.addbeh.2015.08.007.
11.
SchepisTSRaoU. Smoking cessation for adolescents: a review of pharmacological and psychosocial treatments. Curr Drug Abuse Rev. 2008;1(2):142–155.
12.
FlamanLMPlotnikoffRCNykiforukCIJRaineK. Mechanisms for understanding the facilitators and barriers to capacity building for chronic disease prevention activities: an illustration. Health Promot Pract. 2011;12(6):858–866. doi:10.1177/1524839910366424.
13.
McLeroyKRBibeauDStecklerAGlanzK. An ecological perspective on health promotion programs. Health Educ Behav. 1988;15(4):351–377. doi:10.1177/109019818801500401.
14.
TyasSLPedersonLL. Psychosocial factors related to adolescent smoking: a critical review of the literature. Tob Control. 1998;7(4):409–420. doi:10.1136/tc.7.4.409.
15.
Al-DelaimyWKWhiteMMPierceJP. Adolescents’ perceptions about quitting and nicotine replacement therapy: findings from the California Tobacco Survey. J Adolesc Health. 2006;38(4):465–468. doi:10.1016/j.jadohealth.2005.02.005.
16.
WakefieldMSzczypkaGTerry-McElrathY. Mixed messages on tobacco: comparative exposure to public health, tobacco company- and pharmaceutical company-sponsored tobacco-related television campaigns in the United States, 1999–2003. Addiction. 2005;100(12):1875–1883. doi:10.1111/j.1360-0443.2005.01298.x.
17.
RiveraMDBirnbaumAS. Health promotion practice and the road ahead: addressing enduring gaps and encouraging greater practice-to-research translation. Health Promot Pract. 2010;11(6):779–783. doi:10.1177/1524839910380248.
18.
SorensenGBarbeauEHuntMKEmmonsK. Reducing social disparities in tobacco use: a social-contextual model for reducing tobacco use among blue-collar workers. Am J Public Health. 2004;94(2):230–239. doi:10.2105/AJPH.94.2.230.
19.
Centers for Disease Control and Prevention. National Breast and Cervical Cancer Early Detection Program Social Ecological Model. 2013. https://www.cdc.gov/cancer/nbccedp/sem.htmaccessed March 15, 2017.
20.
HigginsJPTGreenS, eds. Cochrane Handbook for Systematic Reviews of Interventions. 2011. http://handbook.cochrane.org/accessed March 15, 2017.
DaltonWTKlesgesLMHendersonLSomesGRobinsonLJohnsonKC. Gender, smoking status, and risk behavior attitudes explain adolescents’ patterns of nicotine replacement therapy use. Addict Behav. 2010;35(2):147–151. doi:10.1016/j.addbeh.2009.09.024.
24.
GerlachKKRohayJMGitchellJGShiffmanS. Use of nicotine replacement therapy among never smokers in the 1999–2006 National Health and Nutrition Examination Surveys. Drug Alcohol Depend. 2008;98(1-2):154–158. doi:10.1016/j.drugalcdep.2008.05.001.
25.
HamOKLeeYJ. Use of the transtheoretical model to predict stages of smoking cessation in Korean adolescents. J Sch Health. 2007;77(6):319–326. doi:10.1111/j.1746-1561.2007.00213.x.
26.
KlesgesLMJohnsonKCSomesGZbikowskiSRobinsonL. Use of nicotine replacement therapy in adolescent smokers and nonsmokers. Arch Pediatr Adolesc Med. 2003;157(6):517–522. doi:10.1001/archpedi.157.6.517.
27.
LaneNELeatherdaleSTAhmedR. Use of nicotine replacement therapy among Canadian youth: data from the 2006–2007 National Youth Smoking Survey. Nicotine Tob Res. 2011;13(10):1009–1014. doi:10.1093/ntr/ntr091.
28.
MorrisCDMayMGDevineKSmithSDeHayTMahalikJ. Multiple perspectives on tobacco use among youth with mental health disorders and addictions. Am J Health Promot. 2011;25(suppl 5):S31–S37. doi:10.4278/ajhp.100610-QUAL-179.
29.
RainioSUHuhtalaHSARimpelaAH. Use and acquisition of nicotine replacement therapy products among underaged adolescents after deregulation of the sales. Nicotine Tob Res. 2010;12(8):870–873. doi:10.1093/ntr/ntq110.
30.
RaisamoSPatjaKBromsUKaprioJRimpeläA. Does self-rated addiction and the heaviness of smoking index predict nicotine replacement therapy product use in adolescent smokers?J Child Adolesc Subst Abuse. 2013;22(4):284–294. doi:10.1080/1067828X.2012.747889.
31.
RaisamoSUDokuDTRimpeläAH. Adolescents’ self-reported reasons for using nicotine replacement therapy products: a population-based study. Addict Behav. 2011;36(9):945–947. doi:10.1016/j.addbeh.2011.05.005.
32.
SwansonANShoptawSHeinzerlingKG. Up in smoke? A preliminary open-label trial of nicotine replacement therapy and cognitive behavioral motivational enhancement for smoking cessation among youth in Los Angeles. Subst Use Misuse. 2013;48(14):1553–1562. doi:10.3109/10826084.2013.808218.
33.
Botello-HarbaumMSchroederJCollinsCMoolchanE. Nicotine replacement therapy use among adolescent smokers seeking cessation treatment. Ethn Dis. 2010;20(2):180–184.
34.
MoolchanETSchroederJR. Quit attempts among African American teenage smokers seeking treatment: gender differences. Prev Med. 2004;39(6):1180–1186. doi:10.1016/j.ypmed.2004.04.050.
35.
HylandABradfordDBradfordD. Drug counselor report of adolescents abuse of nicotine replacement therapy. J Addict Dis. 2006;24(4):105–113. doi:10.1300/J069v24n04_08.
36.
Owusu-DaboELewisSMcNeillAGilmoreABrittonJ. Support for smoke-free policy, and awareness of tobacco health effects and use of smoking cessation therapy in a developing country. BMC Public Health. 2011;11:572. doi:10.1186/1471-2458-11-572.
37.
AmosAWiltshireSHawSMcNeillA. Ambivalence and uncertainty: experiences of and attitudes towards addiction and smoking cessation in the mid-to-late teens. Health Educ Res. 2005;21(2):181–191. doi:10.1093/her/cyh054.
38.
MolyneuxALewisSColemanT. Designing smoking cessation services for school-age smokers: a survey and qualitative study. Nicotine Tob Res. 2006;8(4):539–546. doi:10.1080/14622200600789817.
39.
KingJLWongTJMertenJWPomeranzJL. Assessing attitudes toward nicotine replacement therapy for adolescent smoking cessation. Fla Public Health Rev. 2016;13:24–28.
40.
KillenJDAmmermanSRojasNVaradyJHaydelFRobinsonTN. Do adolescent smokers experience withdrawal effects when deprived of nicotine?. Exp Clin Psychopharmacol. 2001;9(2):176–182.
41.
LeatherdaleSTMcDonaldPW. Youth smokers’ beliefs about different cessation approaches: are we providing cessation interventions they never intend to use?Cancer Causes Control. 2007;18(7):783–791. doi:10.1007/s10552-007-9022-8.
42.
WiiumNOverlandSAarøLE. Smoking cessation among Norwegian adolescents and young adults: preferred cessation methods: smoking cessation among young people. Scand J Psychol. 2011;52(2):154–160. doi:10.1111/j.1467-9450.2010.00851.x.
43.
LawranceKG. Adolescent smokers’ preferred smoking cessation methods. Can J Public Health Rev Can Santé Publique. 2001;92(6):423–426.
44.
JannoneLO’ConnellKA. Coping strategies used by adolescents during smoking cessation. J Sch Nurs. 2007;23(3):177–184. doi:10.1622/1059-8405(2007)023[0177: CSUBAD]2.0.CO;2.
45.
BuswellMDuncanP. Ambivalence and fluidity in the teenage smoking and quitting experience: lessons from a qualitative study at an English secondary school. Health Educ J. 2013;72(4):408–416. doi:10.1177/0017896912446561.
46.
O’LoughlinJKishchukNDiFranzaJTremblayMParadisG. The hardest thing is the habit: a qualitative investigation of adolescent smokers’ experience of nicotine dependence. Nicotine Tob Res. 2002;4(2):201–209. doi:10.1080/14622200210123000.
47.
BaileySRHagenSAJefferyCJ. A randomized clinical trial of the efficacy of extended smoking cessation treatment for adolescent smokers. Nicotine Tob Res. 2013;15(10):1655–1662. doi:10.1093/ntr/ntt017.
48.
HurtRDCroghanGABeedeSDWolterTDCroghanITPattenCA. Nicotine patch therapy in 101 adolescent smokers: efficacy, withdrawal symptom relief, and carbon monoxide and plasma cotinine levels. Arch Pediatr Adolesc Med. 2000;154(1):31–37.
49.
MoolchanETRobinsonMLErnstM. Safety and efficacy of the nicotine patch and gum for the treatment of adolescent tobacco addiction. Pediatrics. 2005;115(4):e407–e414. doi:10.1542/peds.2004-1894.
50.
ScherphofCSvan den EijndenRJJMLugtigPEngelsRCMEVolleberghWAM. Adolescents’ use of nicotine replacement therapy for smoking cessation: predictors of compliance trajectories. Psychopharmacology (Berl). 2014;231(8):1743–1752. doi:10.1007/s00213-014-3511-8.
ProkhorovAVHudmonKSde MoorCAKelderSHConroyJLOrdwayN. Nicotine dependence, withdrawal symptoms, and adolescents’ readiness to quit smoking. Nicotine Tob Res. 2001;3(2):151–155. doi:10.1080/14622200124778.
53.
DickmannPJMooneyMEAllenSSHansonKHatsukamiDK. Nicotine withdrawal and craving in adolescents: effects of sex and hormonal contraceptive use. Addict Behav. 2009;34(6-7):620–623. doi:10.1016/j.addbeh.2009.03.033.
54.
WymanJPriceJHJordanTRDakeJATelljohannSK. Parents’ perceptions of the role of schools in tobacco use prevention and cessation for youth. J Community Health. 2006;31(3):225–248. doi:10.1007/s10900-005-9010-4.
55.
PriceJHYinglingFDakeJATelljohannSK. Adolescent smoking cessation services of school-based health centers. Health Educ Behav. 2003;30(2):196–208. doi:10.1177/1090198102251032.
56.
ChunJGuydishJChanYF. Smoking among adolescents in substance abuse treatment: a study of programs, policy, and prevalence. J Psychoactive Drugs. 2007;39(4):443–449. doi:10.1080/02791072.2007.10399883.
57.
MuilenburgJLLaschoberTCEbyLT. Substance use disorder counselors’ reports of tobacco cessation services availability, implementation, and tobacco-related knowledge. J Adolesc Health. 2015;57(3):327–333. doi:10.1016/j.jadohealth.2015.06.001.
58.
MilneBTownsS. Do paediatricians provide brief intervention for adolescents who smoke?J Paediatr Child Health. 2007;43(6):464–468. doi:10.1111/j.1440-1754.2007.01112.x.
59.
PriceJHJordanTRDakeJA. Pediatricians’ use of the 5 A’s and nicotine replacement therapy with adolescent smokers. J Community Health. 2007;32(2):85–101. doi:10.1007/s10900-006-9035-3.
60.
DurkinSWakefieldMSpittalM. Looking for boomerang effects: a pre–post experimental study of the effects of exposure of youth to television advertising for nicotine replacement therapy and Zyban®. Addict Behav. 2006;31(12):2158–2168. doi:10.1016/j.addbeh.2006.02.020.
61.
WakefieldMDurrantR. Effects of exposure of youths at risk for smoking to television advertising for nicotine replacement therapy and Zyban®: An Experimental Study. Health Commun. 2006;19(3):253–258. doi:10.1207/s15327027hc1903_7.
62.
JohnsonKCKlesgesLMSomesGWCodayMCDeBonM. Access of over-the-counter nicotine replacement therapy products to minors. Arch Pediatr Adolesc Med. 2004;158(3):212–216. doi:10.1001/archpedi.158.3.212.
63.
LaneNELeatherdaleSTDubinJAHammondD. Student and school characteristics associated with use of nicotine replacement therapy: a multilevel analysis among Canadian youth. Addict Behav. 2012;37(7):811–816. doi:10.1016/j.addbeh.2012.03.012.
64.
LangleyTEHuangYLewisSMcNeillAColemanTSzatkowskiL. Prescribing of nicotine replacement therapy to adolescents in England: prescribing of NRT to adolescents. Addiction. 2011;106(8):1513–1519. doi:10.1111/j.1360-0443.2011.03449.x.
65.
HansonKAllenSJensenSHatsukamiD. Treatment of adolescent smokers with the nicotine patch. Nicotine Tob Res. 2003;5(4):515–526. doi:10.1093/ntr/5.4.515.
66.
ScherphofCSvan den EijndenRJJMEngelsRCMEVolleberghWAM. Short-term efficacy of nicotine replacement therapy for smoking cessation in adolescents: a randomized controlled trial. J Subst Abuse Treat. 2014;46(2):120–127. doi:10.1016/j.jsat.2013.08.008.
67.
HansonKZyllaEAllenSLiZHatsukamiDK. Cigarette reduction: an intervention for adolescent smokers. Drug Alcohol Depend. 2008;95(1-2):164–168. doi:10.1016/j.drugalcdep.2007.12.002.
68.
KillenJDRobinsonTNAmmermanS. Randomized clinical trial of the efficacy of bupropion combined with nicotine patch in the treatment of adolescent smokers. J Consult Clin Psychol. 2004;72(4):729–735. doi:10.1037/0022-006X.72.4.729.
69.
RoddyE. Use of nicotine replacement therapy in socioeconomically deprived young smokers: a community-based pilot randomised controlled trial. Tob Control. 2006;15(5):373–376. doi:10.1136/tc.2005.014514.
70.
ScherphofCSvan den EijndenRJJMEngelsRCMEVolleberghWAM. Long-term efficacy of nicotine replacement therapy for smoking cessation in adolescents: a randomized controlled trial. Drug Alcohol Depend. 2014;140:217–220. doi:10.1016/j.drugalcdep.2014.04.007.
KobusK. Peers and adolescent smoking. Addiction. 2003;98(suppl 1):37–55. doi:10.1046/j.1360-0443.98.s1.4.x.
73.
TingenMSAndrewsJOStevensonAW. Primary and secondary tobacco prevention in youth. Annu Rev Nurs Res. 2009;27(1):171–193. doi:10.1891/0739-6686.27.171.
74.
HenningfieldJE. Nicotine medications for smoking cessation. N Engl J Med. 1995;333(18):1196–1203. doi:10.1056/NEJM199511023331807.
75.
StevensABMcDanielKSGloverEDWallaceLS. Are instructions for over-the-counter nicotine replacement therapy products readable?Am J Health Behav. 2007;31(1):79–84. doi:10.5993/AJHB.31.s1.10.
