Non-Thrombogenicity by Novel Surface Modification Methods

Abstract

Three novel methods, recently developed by us, for the synthesis of non-thrombogenetic materials were reviewed. The first was the utilization of poly(vinyl sulfonate) as a heparinoid and a newly synthesized polymerizable-thrombin-inhibitor. The chemicals were grafted onto the surfaces of materials. The second was the use of thrombin-substrate-analog peptide. The immobilized peptide was decomposed by blood coagulation factors and inhibited thrombus formation on the surface. The third method was the enhancement of endothelialization by immobilization of biosignal molecules. The immobilized biosignals remarkedly accelerated the growth of endothelial cells.