Indomethacine is an analgesic and antiinflammatory drug which has antiplatelet and antithrombotic properties. In our work, we have tried to immobilize the same onto a polymer surface covalently. Surface parameters like water contact angle and platelet adhesion are studied. Similar studies are conducted on heparin immobilized surfaces, for relative comparison.
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References
1.
BrashJ. L.LymanD. J.. “Adsorption of Plasma Protein in Solution to Uncharged, Hydrophobic Polymer Surfaces,”J. Bio. Med. Mater. Res., 3:179–189 (1969).
2.
BaierR. E.“The Organization of Blood Components Near Interfaces,”Ann. N.Y. Acad. Sci., 283:1736 (1977).
3.
MenysV. C.DaviesJ. A.. “Inhibition of Platelet Adhesion to Aortic Sub Endothelium by Indomethacine,”Thromb. Res., 37:225–229 (1985).
4.
ErtelS. I.RatnerB. D.HorbettT. A.. “Endothelial Cell Growth on RF Plasma Deposited Polymers,”3rd World Biomaterials Conference, 3B2-13 (1988).
5.
SharmaC. P.ChandyT.SunnyM. C.. “Inhibition of Platelet Adhesion to Glow Discharge Modified Surfaces,”J. Biomat. Appln., 1(4):533–552 (1987).
6.
EbertC. D.LeeE. S.KimS. W.. “The Antiplatelet Activity of Immobilized Prostacyclin,”J. Biomed. Mat. Res., 16:629–638 (1982).
