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Abstract

Wound healing refers to the healing process of skin and other tissues appear to be broken or defective after one body suffers external force. Accelerating wound healing through the use of natural products isolated from plants and microbes is a hot research topic. Tetrahydrocurcumin is one of the major in vivo colorless hydrogenated metabolites of curcumin with superior wound healing and anti-inflammatory properties. The poor bioavailability of these curcuminoids limits their clinical applications. Preparation of curcuminoids-loaded nanoparticles is one appropriate method of addressing this issue. In this study, tetrahydrocurcumin nanoparticles were firstly used for wound healing. In vitro experiments revealed that tetrahydrocurcumin-loaded MPEG-PLA nanoparticles (THC-NPs) could stimulate the closure of defect by enhancing directional migration of human fibroblasts in tetrahydrocurcumin dose-dependent manner. In addition, we also evaluated the effect of sodium alginate/chitosan dressings featuring THC-NPs on wound healing. We found that the nanometer dressings (sodium alginate/chitosan dressings featuring THC-NPs) could accelerate wound healing by improving collagen deposition, increasing vascular density in a rat model of wound repair. These results demonstrated that THC-NPs could promote cutaneous healing by increasing the synthesis of collagen I and III, revascularization and improving the migration of fibroblasts. Thus, THC-NPs have the potential for enhancing wound healing progress.

Keywords

Tetrahydrocurcumin nanoparticles dressing wound healing fibroblasts rats

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An evaluation of the wound healing potential of tetrahydrocurcumin-loaded MPEG-PLA nanoparticles

Abstract

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