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Abstract

Zeolite is a multifunctional material, which recently exhibited promising prospects in emerging biological and medical applications. This study reported a new bio-inorganic hybrid of zeolite-fibrin clot composite serving as haemostatic agent in haemophilia A. The zeolite-fibrin clot composite promoted haemocompatibility and helped to achieve short clotting time both in vitro (22 ± 3 s vs. >600 s) and in vivo (4.5 min vs. >60 min) compared to control in coagulation factor VIII deficiency bleeding model. Therefore, in situations of surgical operation or accidental injury, this effective and ready-to-use haemostatic agent may provide rapid haemostasis for haemophilia A patients.

Keywords

Zeolite-fibrin clot composite haemostatic agent haemophilia A

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References

Johansson

Stensballe

Oliveri

et al . How I treat patients with massive hemorrhage. Blood 2014; 124: 3051–3058.

Rossaint

Bouillon

Cerny

et al . The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care 2016; 20: 100–100.

Rodeghiero

Castaman

Tosetto

How I treat von Willebrand disease. Blood 2009; 114: 1158–1165.

Mannucci

PM.

Back to the future: a recent history of haemophilia treatment. Haemophilia 2008; 14: 10–18.

Motto

Paola

JD.

Diagnostic approach to von Willebrand disease. Blood 2015; 125: 2029–2037.

Graw

Brackmann

Oldenburg

et al . Haemophilia A: from mutation analysis to new therapies. Nat Rev Genet 2005; 6: 488–501.

Schramm

The history of haemophilia – a short review. Thromb Res 2014; 134: S4–S9.

Peyvandi

Garagiola

Young

The past and future of haemophilia: diagnosis, treatments, and its complications. Lancet 2016; 388: 187–197.

Franchini

Mannucci

PM.

Hemophilia A in the third millennium. Blood Rev 2013; 27: 179–184.

10.

Srivastava

Brewer

Mauserbunschoten

et al . Guidelines for the management of hemophilia. Haemophilia 2013; 19: e1–e47.

11.

Wight

Paisley

et al . Control of bleeding in patients with haemophilia A with inhibitors: a systematic review. Haemophilia 2003; 9: 464–520.

12.

Von Depka

Managing acute bleeds in the patient with haemophilia and inhibitors: options, efficacy and safety. Haemophilia 2005; 11: 18–23.

13.

Stephensen

Tait

Brodie

et al . Changing patterns of bleeding in patients with severe haemophilia A. Haemophilia 2009; 15: 1210–1214.

14.

Quintana-Molina

Martinez-Bahamonde

Gonzalez-Garcia

et al . Surgery in haemophilic patients with inhibitor: 20 years of experience. Haemophilia 2004; 10: 30–40.

15.

Granville-Chapman

Jacobs

Midwinter

MJ.

Pre-hospital haemostatic dressings: a systematic review. Injury 2011; 42: 447–459.

16.

Bennett

Littlejohn

Review of new topical hemostatic dressings for combat casualty care. Mil Med 2014; 179: 497–514.

17.

Voelker

From soldiers to civilians. JAMA 2016; 315: 456–2

18.

Pourshahrestani

Zeimaran

Djordjevic

et al . Inorganic hemostats: the state-of-the-art and recent advances. Mater Sci Eng C Mater Biol Appl 2016; 58: 1255–1268.

19.

Liao

Zhang

et al . In situ generated thrombin in the protein corona of zeolites: relevance of the functional proteins to its biological impact. Nano Res 2014; 7: 1457–1465.

20.

Lane

Philippou

Huntington

JA.

Directing thrombin. Blood 2005; 106: 2605–2612.

21.

Huey

Basadonna

Methods of providing hemostasis in anti-coagulant blood. US20080254146A1, USA, 2008.

22.

Long

Zhang

Huang

et al . Emerging nanoclay composite for effective hemostasis. Adv Funct Mater 2018; 28: 1704452.

23.

Baker

Sawvel

Zheng

et al . Controlling bioprocesses with inorganic surfaces: layered clay hemostatic agents. Chem Mater 2007; 19: 4390–4392.

24.

Monopoli

Walczyk

Campbell

et al . Physical-chemical aspects of protein corona: relevance to in vitro and in vivo biological impacts of nanoparticles. J Am Chem Soc 2011; 133: 2525–2534.

25.

Rahimi

Bakhtiari

et al . Zeolite nanoparticles for selective sorption of plasma proteins. Sci Rep 2015; 5: 17259–2.

26.

Yildirim

Ozgur

Bayindir

Impact of mesoporous silica nanoparticle surface functionality on hemolytic activity, thrombogenicity and non-specific protein adsorption. J Mater Chem B 2013; 1: 1909–1920.

27.

Kavakli

Fibrin glue and clinical impact on haemophilia care. Haemophilia 1999; 5: 392–396.

28.

Bayır

Eryılmaz

Demirbilek

et al . Comparison of the topical haemostatic efficacy of nano-micro particles of clinoptilolite and kaolin in a rat model of haemorrhagic injury. Eur J Trauma Emerg Surg 2016; 42: 77–86.

29.

Arnaud

Tomori

Carr

et al . Exothermic reaction in zeolite hemostatic dressings: QuikClot ACS and ACS+®. Ann Biomed Eng 2008; 36: 1708–1713.

30.

Fathi

Sikorski

Christodoulides

et al . Zeolite-loaded alginate-chitosan hydrogel beads as a topical hemostat. J Biomed Mater Res B Appl Biomater 2018; 106: 1662–1671.

31.

Xiang

et al . Fabrication of a photo-crosslinked gelatin hydrogel for preventing abdominal adhesion. RSC Adv 2016; 6: 92449–92453.

32.

Chen

Guo

Wicks

et al . Quickly promoting angiogenesis by using a DFO-loaded photo-crosslinked gelatin hydrogel for diabetic skin regeneration. J Mater Chem B 2016; 4: 3770–3781.

33.

Sun

Zheng

Cheng

et al . Two-dimensional electrospun nanofibrous membranes for promoting random skin flap survival. RSC Adv 2016; 6: 9360–9369.

34.

McManus

Hurtado

Pusateri

et al . A case series describing thermal injury resulting from zeolite use for hemorrhage control in combat operations. Prehospital Emerg Care 2007; 11: 67–71.

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Zeolite-fibrin clot composite as a haemostatic agent for haemophilia A

Abstract

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Supplementary Material