Restricted accessResearch articleFirst published online 2009-05
Synthesis of Bioactive HEMA—MPS—CaCl 2 Hybrid Gels: Effects of Catalysts in the Sol—Gel Processing on Mechanical Properties and in vitro Hydroxyapatite Formation in a Simulated Body Fluid
We investigated synthetic conditions for the fabrication of bioactive hybrid gels from monomers of 2-hydroxyethylmethacrylate (HEMA) and 3-methacryloxypropyltrimethoxysilane (MPS) in combination with CaCl2, at a starting molar ratio of HEMA: MPS : CaCl2 of 9 : 1 : 1. Hydroxyapatite formation, essential to show bone bonding, was observed on the HEMA— MPS—CaCl 2 hybrid gels with the added catalysts NH3 or HCl with a molar ratio to MPS of 0.1, but not on the hybrid gel with HCl at a molar ratio to MPS of 1. The mechanical properties of the gels were dependent on the catalysts, which may affect the microstructures that develop during sol—gel processing.
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