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Abstract

This study reports the properties of tableted microparticles based on high-amylose corn starch (HACS)–pectin blend polymers as the controlled release system for diclofenac sodium (DS). HACS–pectin blend microparticles are prepared through a modified process by the spray drying technique, which is a widely used microencapsulation technique in the pharmaceutical industry. The mean particle size of various formulations of blend microparticles is in the range of 5.8–7.3 μm. Fourier transform infrared (FTIR) spectroscopy study reveals the absence of well-defined interaction between HACS–pectin and polymers–DS. The blend microparticles thus prepared were compressed into tablets using the directly compressible excipients. A cross-sectional view of the tablet reveals the presence of nearly spherical shaped particles in the tablet, suggesting that the system chosen is ideal for tableting. In vitro drug release study indicates that tableted microparticulate system is found to be suitable for the manipulation of release behavior for DS in the gastrointestinal tract. Release mechanism of the DS from tableted microparticles is by Fickian diffusion since the value of n approaches 0.5.

Keywords

microparticles controlled release diclofenac sodium tableted microparticles spray drying pectin high-amylose corn starch

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References

Chourasia, M.K. and Jain, S.K. (2004). Polysaccharides for Colon Targeted Drug Delivery , Drug Deliv., 11(2): 129–148 .

Liu, L. , Fishman, M. , Kost, J. and Hicks, K.B. (2003). Pectin-based Systems for Colon-specific Drug Delivery via Oral Route , Biomaterials, 24(19): 3333–3343 .

Desai, K.G. and Park, H.J. (2005). Encapsulation of Vitamin C in Tripolyphosphate Cross-linked Chitosan Microspheres by Spray Drying , J. Microencapsulation, 22(2): 179–192 .

Desai, K.G. and Park, H.J. (2005). Preparation and Characterization of Drug-loaded Chitosan-tripolyphosphate Microspheres Prepared by Spray Drying , Drug Develop. Res., 64(2): 114–128 .

Desai, K.G. and Park, H.J. (2005). Preparation of Cross-linked Chitosan Microspheres by Spray Drying: Effect of Cross-linking Agent on the Properties of Spray Dried Microspheres , J. Microencapsulation, 22: 377–395 .

Desai, K.G. (2005). Preparation and Characteristics of High Amylose Corn Starch/Pectin Blend Microparticles , AAPS PharmSciTech., 6: E202–E208 .

Galeone, M. , Nizzola, L. , Cacioli, D. and Mosie, G. (1981). In vitro Demonstration of Delivery Mechanism from Sustained Release Pellets , Curr. Ther. Res., 29: 217–234 .

Martindale (2002). In: Sweetman, S.C. (ed.), The Complete Drug Reference, 33rd edn, Pharmaceutical Press, London .

Aç1kgöz, M. , Kaş, H.S. and H1ncal, A.A. (1994). Diclofenac Sodium, Bioavailability File, FABAD , Far. Bil. Der., 19(1): 37–47 .

10.

Sinha, V.R. , Singla, A.K. , Wadhawan, S. , Kaushik, R. , Kumria, R. , Bansal, K. and Dhawan, S. (2004). Chitosan Microspheres as a Potential Carrier for Drugs , Int. J. Pharm., 274(1–2): 1–33 .

11.

Liu, C.-G. , Desai, K.G. , Chen, X.-G. and Park, H.J. (2005). Linolenic Acid-modified Chitosan for Formation of Self-assembled Nanoparticles , J. Agric. Food Chem., 53(2): 437–441 .

12.

Liu, C.-G. , Desai, K.G. , Chen, X.-G. and Park, H.J. (2005). Preparation and Characterization of Nanoparticles Containing Trypsin based on Hydrophobically Modified Chitosan , J. Agric. Food Chem., 53(5): 1728–1733 .

13.

Fu, Y.J. , Mi, F.L. , Wong, T.B. and Shyu, S.S. (2001). Characteristic and Controlled Release of Anticancer Drug Loaded Poly (D,L-lactide) Microparticles Prepared by Spray Drying Technique , J. Microencapsulation, 18(6): 733–747 .

14.

Dumoulin, Y. , Cartilier, L.H. and Mateescu, M.A. (1999). Cross-linked Amylose Tablets Containing α-amylose: An Enzymatically-controlled Drug Release System , J. Control. Release, 60(2–3): 161–167 .

15.

Désévaux, C. , Dubreuil, P. and Lenaerts, V. (2002). Characterization of Crosslinked High Amylose Starch Matrix Implants: 1. In vitro Release of Ciprofloxacin , J. Control. Release, 82(1): 83–93 .

16.

Mulhbacher, J. , Ispas-Szabo, P. , Lenaerts, V. and Mateescu, M.A. (2001). Cross-linked High Amylose Starch Derivatives as Matrices for Controlled Release of High Drug Loadings , J. Control. Release, 76(1–2): 51–58 .

17.

Prior, S. , Gamazo, C. , Irache, J.M. , Merkle, H.P. and Gander, B. (2000). Gentamicin Encapsulation in PLA: PLGA Microspheres in View of Treating Brucella Infections , Int. J. Pharm., 196(1): 115–125 .

18.

Kim, J.H. and Fassihi, R. (1997). Application of a Binary Polymer System in Drug Release Rate Modulation. 2. Influences of Formulation Variables and Hydrodynamic Conditions on Release Kinetics , J. Pharm. Sci., 86(3): 323–328 .

19.

Kwabena, O.K. and Fell, J.T. (2001). Biphasic Drug Release: The Permeability of Films Containing Pectin, Chitosan and HPMC , Int. J. Pharm., 226(1–2): 139–145 .

20.

Turkoglu, M. and Ugurlu, T. (2002). In vitro Evaluation of Pectin-HPMC Compression Coated 5-Aminosaclicylic Acid Tablets for Colonic Delivery , Eur. J. Pharm. Biopharm., 53(1): 65–73 .

21.

Desai, K.G. and Pramod Kumar, T.M. (2004). Preparation and Evaluation of a Novel Buccal Adhesive System , AAPS PharmSciTech., 5(3): Article 35.

Properties of Tableted High-Amylose Corn Starch–Pectin Blend Microparticles Intended for Controlled Delivery of Diclofenac Sodium

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