Litovitz TL, Felberg L., White S., et al The 1996 annual report of the American Association of Poison Control Centers toxic exposure surveillance systemAm J Emerg Med1997,15447-501
2.
Flanagan RJ, Mant TGComa and metabolic acidosis early in severe acute paracetamol poisoningHum Toxicol1986, 5179-182
3.
Smilkstein MJ , Knapp GL, Kulig KW, et al Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdoseN Engl J Med1988,3191557-1562
4.
Lyons L., Studdiford JS, Sommaripa AMTreatment of acetammophen overdose with N-acetylcysteine [letter]N Engl J Med1977,296174-175
5.
Prescott LF, Illingworth RN, Critchley JA, et al Intravenous N-acetylcysteme the treatment of choice for paracetamol poisoningBr Med J1979,21097-1100
6.
Yip L., Dart RC, Hurlbut KMIntravenous administration of oral N-acetylcysteineCrit Care Med1998,2640-43
7.
Smilkstein MJ , Bronstem AC, Linden C., et al Acetaminophen overdose a 48-hour intravenous N-acetylcysteine treatment protocolAnn Emerg Med1991,20.1058-1063
8.
Harrison PM, Keays R., Bray GP, et al Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteineLancet 1990,3351572-1573
9.
Keays R., Harrison PM, Wendon JA, et al Intravenous acetylcysteme in paracetamol induced fulmmant hepatic failure a prospective controlled trialBMJ1991,3031026-1029
10.
Miller LF, Rumack BHClinical safety of high oral doses of acetylcysteineSemin Oncol1983,10(suppl 1) 76-85
11.
Mant TG, Tempowski JH, Volans GN, et al Adverse effects of N-acetylcysteine and effects of overdoseBr Med J1984, 289217-219
12.
Tennenbem M.Hypersensitivity-like reactions to N-acetylcysteineVet Hum Toxicol1984,263-5
Trey C., Davidson CSThe management of fulminant hepatic failure. New YorkGrune and Stratton, 1970282-298
15.
O'Grady JGParacetamol hepatotoxicity how to preventJ R Soc Med1997,90368-370
16.
Holdmess MRClinical pharmacokinetics of N-acetylcystemeClin Pharmacokmet1991,20123-134
17.
Lauterburg BH, Corcoran G., Mitchell JRMechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in ratsJ Clin Invest1983,71980-991
18.
Harrison PM , Wendon JA, Gimson AE, et al Improvement by acetylcysteme of hemodynamics and oxygen transport in fulmmant hepatic failureN Engl J Med1991,3241852-1857
19.
Watanabe FD, Shackleton CR, Cohen SM, et al Treatment of acetaminophen-induced fulmmant hepatic failure with a bioartificial liverTransplant Proc1997 ,29487-488
20.
Pereira SP, McCarthy M., Ellis AJ, et al Auxiliary partial orthotopic liver transplantation for acute liver failureJ Hepatol1997, 261010-1017
21.
Canalese J. , Gimson AE, Davis M., et al Factors contributing to mortality in paracetamol-induced hepatic failureBr Med J Clin Res Ed1981,282(6259) 199-201
O'Grady JG, Alexander GJ, Hayllar KM, et al Early indicators of prognosis in fulmmant hepatic failureGastroenterology1989,97439-445
24.
Pereira LM, Langley PG, Hayllar KM, et al Coagulation factor V and VIII/V ration as predictors of outcome in paracetamol induced fulmmant hepatic failure relation to other prognostic indicatorsGut1992,3398-102
25.
Devlin J., Wendon J., Heaton N., et al Pretransplantation clinical status and outcome of emergency transplantation for acute liver failureHepatology1995,211018-1024
26.
Gazzard BG, Henderson JM, Williams R.Early changes in coagulation following a paracetamol overdose and a controlled trial of fresh frozen plasma therapyGut1975 ,16617-620
27.
Katelans PH , Jones DBFulmmant hepatic failureMed Clin N Am1989,73955-970
28.
Wendon JA, Harrison PM, Keays R., et al Cerebral blood flow and metabolism in fulminant hepatic failureHepatology1994,191407-1413
29.
Ede RJ, Gimson AE, Bihari D., et al Controlled hyperventilation in the prevention of cerebral oedema in fulminant hepatic failureJ Hepatol1986 ,243-51
30.
Ede RJ, Gimson AE, Canalese J., et al Cerebral oedema and monitoring of intracranial pressure in fulminant hepatic failureGastroenterol Jpn1982,17163-176
31.
Canalese J. , Gimson AE, Davis C., et al Controlled trial of dexamethasone and mannitol for the cerebral oedema of fulminant hepatic failureGut1982,23625-629
32.
Bernard GRN-acetylcysteine in expenmental and clinical acute lung injuryAm J Med1991,91545-594
33.
McJunkin B. , Barwick KW, Little WC, et al Fatal massive hepatic necrosis following acetaminophen overdoseJAMA1976, 2361874-1875
34.
Rogers LK, Moorthy B., Smith CVAcetaminophen binds to mouse hepatic and renal DNA at human therapeutic dosesChem Res Toxicol1997,10470-476
35.
Satav JG, Bhattacharya RKRespiratory functions in kidney mitochondria following paracetamol administration to young-adult and old ratsIndian J Med Res1997,105131-135
36.
Plumford NR, Hinson JA, Potter DW, et al Immunochemical quantitation of 3-(cystein-S-yl)acetaminophen adducts in serum and liver proteins of acetaminophen-treated miceJ Pharmacol Exp Ther1988,248190-196
37.
Pirmohamed M., Madden S., Park BKIdiosyncratic drug reactions Metabolic bioactivation as a pathogenic mechanismClin Pharmacokmet1996,31.215-230
38.
Harvison PJ , Guengench FP, Rashed MS, et al Cytochrome P-450 isozyme selectivity in the oxidation of acetaminophenChem Res Toxicol1988,147-52
39.
Blakely P., McDonald BRAcute renal failure due to acetaminophen ingestion a case report and review of the literatureJ Am Soc Nephrol1995;648-53
40.
Kleinman J., Breitenfield RV, Roth DAAcute renal failure associated with acetaminophen ingestion report of a case and review of the literatureClin Nephrol1980,14201-202
41.
Boyer TD, Rouff SLAcetaminophen-induced hepatic necrosis and renal failureJAMA1971,218440-441
42.
Bonkovsky HL, Kane RE, Jones DP, et al Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition evidence for m-creased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiencyHepatology1994,191141-1148
Gabnel R., Caldwell J., Hartley RBAcute tubular necrosis, caused by therapeutic doses of paracetamol? Clin Nephrol1982,18269-271
45.
Jeffery WH, Lafferty WEAcute renal failure after acetammophen overdose report of two casesAm J Hosp Pharm1981, 281355-1358
46.
Pillans P., Hall C.Paracetamol-induced acute renal failure in the absence of severe liver damageS Afnc Med J1985,67791-792
47.
Prescott LF , Proudfoot AT, Cregeen RJParacetamol-induced acute renal failure in the absence of fulmmant liver damage [letter]Br Med J Clin Res Ed1982,284(6313) 421-422
48.
Mofenson HC , Caraccio TR, Nawaz H., et al Acetaminophen induced pancreatitisJ Toxicol Clin Toxicol1991,29223-230
49.
Caldarola V. , Hassett JM, Hall AH, et al Hemorrhagic pancreatitis associated with acetaminophen overdoseAm J Gastroenterol1986,81579-582
50.
Ferguson DV , Roberts DW, Han-Shu H., et al Acetaminophen induced alterations in pancreatic B cells and serum insulin concentrations in B6C3F1 miceToxicol Appl Pharmacol1990,104225-234
51.
Fang CC, Wang HP, Lin JTErythromycin-induced acute pancreatitisJ Toxicol Clin Toxicol1996,3493-95
Lieber CSMechanisms of ethanol-drug interactionsJ Toxicol Clin Toxicol1994,32631-681
54.
Pirmohamed M., Kitteringham NR, Park BKThe role of active metabolites in drug toxicityDrug Saf1994,11114-144
55.
Sato C., Yoshiro M., Lieber CSIncreased hepatotoxicity of acetaminophen after chronic alcohol consumption in the ratGastroenterology1981,80140-148
56.
Villanueve JP, Roman G., Bruneau J.Pharmacokinetics and metabolism of acetaminophen in normal, alcoholic and cirrhotic subjectsGastroenterol Clin Biol1983,65898-902
57.
Girre C., Hippard E., Bolompo S.Increased metabolism of acetaminophen in chronically ill alcoholic patientsAlcohol Clin Exp Res1993,17170-173
58.
Siegers CP, Oltmans D., Younes M.Effect of alcohol and chronic liver disease on the metabolic-disposal of acetaminophen in manHepatogastroenterology1981,28304-306
59.
Guerri C., Grisoli S.Decreased glutathione in rats due to chronic intake of ethanolFed Proc1978,371541
60.
Lauterburg BH, Davies S., Mitchell JREthanol suppresses hepatic glutathione synthesis in rats in vivoJ Pharmacol Exp Ther1984,2307-11
61.
Whitcomb DC , Block GDAssociation of acetammophen hepatotoxicity with fasting and ethanol useJAMA1994,2721845-1850
62.
Smilkstein MJChronic ethanol use and acute acetaminophen overdose toxicity [abstract]J Toxicol Clin Toxicol1998, 5476
63.
Scheff LB, Cuccherini BA, Zimmerman HJ, et al Acetammophen toxicity in alcoholics a therapeutic misadventureAnn Intern Med1986,104399-404
64.
Schiodt FV, Rochling FA, Casey MD, et al Acetammophen toxicity in a urban community hospitalN Engl J Med1997, 3371112-1117
65.
Kuffner E., Bogdan GM, Dart RCEvaluation of hepatotoxicity in alcoholics from therapeutic doses of acetaminophen [abstract]J Toxicol Clin Toxicol1997,35561
66.
Benson G.Acetaminophen in chronic liver diseaseClin Pharmacol Ther1983,3395-101
67.
Henry D., Dobson A., Turner C.Variability in the risk of major gastrointestinal complications from non-aspirin non-steroidal anti-inflammatory drugs. Gastroenterology1993, 1051078-1088
68.
Brandwene EL , Williams SR, Tunget-Johnson C., et al Refining the level for anticipated hepatotoxicity in acetaminophen poisoningJ Emerg Med1996,14691-695
69.
Bndger S., Henderson K., Glucksman E., et al Deaths from low dose paracetamol poisoningBMJ1998,3161724- 1725
70.
Woo OF, Anderson WR, Sim SY, et al Shorter duration of N-acetylcysteine for acute acetaminophen poisoning [abstract] J Toxicol Clin Toxicol1995,33508
71.
Roth B., Woo OF, Olson K., et al. Validation of a shorter treatment protocol for acute acetaminophen poisoning based on evidence of liver injury [abstract] J Toxicol Clin Toxicol1998,5476
72.
Bizovi KE, Aks SE, Paloucek F., et al Late increase in acetaminophen concentration after overdose of Tylenol Extended ReliefAnn Emerg Med1996 ,28549-551
73.
Cetaruk EW, Dart RC, Hurlbut KM, et al Tylenol Extended Relief overdoseAnn Emerg Med1997,30104-108
74.
Burkhart KK , Janco N., Kulig KW, et al Cimetidine as adjunctive treatment for acetaminophen overdoseHum Exp Toxicol1995,14299-304
75.
Speeg KV, Mitchell MC, Maldonado ALAdditive protection of cimetidine and N-acetylcysteine treatment against acetaminophen-induced hepatic necrosis in the ratJ Pharmacol Exp Ther1985,234550-554
