We present a 42-year-old woman with status asthmaticus who required mechanical ventilation and a combination of maneuvers, including barbiturate coma, general anesthesia, high-dose steroids, bronchoscopic pulmonary toilet, and helium-oxygen ventilation, resulting in successful extubation and eventual hospital discharge. This case report illustrates the possible role of combination therapy in the management of severe asthma exacerbation.
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