Acute Pancreatitis: Work-up and Management

Abstract

Acute pancreatitis is still a common clinical entity that causes significant morbidity and mortality. The most common etiological associations include chronic al coholism, biliary tract disease, iatrogenic (e.g., endo scopic retrograde cholangiopancreatography-induced), hypertriglyceridemia, and idiopathic varieties. New radiological techniques such as dynamic pancreatog raphy appear to be useful in diagnosing and determin ing the extent of necrotizing pancreatitis. Biochem ical variables such as the C-reactive protein and the trypsinogen-activated peptide seem promising in de tecting severe disease within the first few days of hospi talization. Computed tomographic-guided percutane ous aspiration of phlegmonous pancreatitis may be helpful in differentiating infected from noninfected masses. Although current studies have not identified any pharmacological agent as efficacious in improving sur vival, emergency sphincterotomy and removal of im pacted gallstones in severe gallstone pancreatitis may be beneficial in this regard. Prolonged (i.e., 7 day) perito neal dialysis may reduce the severity of pancreatic sep sis. Surgical drainage of infected fluid collections such as abscesses is a well-accepted adjunct to medical therapy. Surgical necrosectomy for necrotizing pancreatitis, however, which is advocated in some aggressive surgi cal units, is not yet commonplace and its role needs to be determined in controlled studies.