A greater understanding of the pathophysiology of gastrointestinal bleeding has been accompanied by a rapid advancement in therapeutic technology. Newer endoscopic and radiologic techniques are being tested to determine their appropriate uses, but pharmacologic therapy has yet to be proved beneficial. A discussion of the newer as well as some traditional therapies is presented.
Marshall M., Bird T.Blood loss and replacement. London: Edward Arnold, 1983
3.
Silverstein FE, Gilbert DA, Tedesco FJ, et al. The national ASGE survey on upper gastrointestinal bleeding. Gastrointest Endosc1981;27:73-102
4.
Bryant LR, Mobin-Uddin K., Dillon ML, Griffen WOComparison of ice water with iced saline solution for gastric lavage in gastroduodenal hemorrhage. Am J Surg1972 ;124:570-572
5.
Ponsky JL, Hoffman M., Swayngim DSSaline irrigation in gastric hemorrhage: the effect of temperature . J Surg Res1980;28:204-205
6.
Gilbert DA, Saunders DR, Peoples J., et al. Failure of iced saline lavage to suppress hemorrhage from experimental bleeding ulcers. Gastroenterology1979;76:1138
7.
Waterman NG, Walker JLThe effect of gastric cooling on hemostasis. Surg Gynecol Obstet1973;137:80-82
Gandhii GMIntraperitoneal and intragastric norepinephrine instillation in massive gastrointestinal bleeding- clinical study. Am J Gastroenterol1976;76:42-48
10.
Peterson WL , Barnett CC, Smith HJ, et al. Routine early endoscopy in upper-gastrointestinal-tract bleeding. N Engl J Med1981;304:925-929
11.
Macleod IA, Mills PRFactors identifying the probability of further hemorrhage after acute upper gastrointestinal hemorrhage. Br J Surg1982 ;69:256-258
12.
Griffiths WJ , Neumann DA, Welsh JDThe visible vessel as an indicator of uncontrolled or recurrent gastrointestinal hemorrhage. N Engl J Med1979;300:1411-1412
13.
Foster DN, Miloszewski KJ, Losowsky MSStigmata of recent hemorrhage in diagnosis and prognosis of upper gastrointestinal bleeding. Br Med J1978;1:1173
14.
Storey D., Bown SG, Swain CP, et al. Endoscopic prediction of recurrent bleeding in peptic ulcers . N Engl J Med1981; 305:915-916
15.
Allison DJ, Hemingway AP, Cunningham DAAngiography in gastrointestinal bleeding. Lancet1982;2:30-33
16.
Athanasoulis CA, Waltman AC, Novelline RA, et al. Angiography : its contribution to the emergency management of gastrointestinal hemorrhage . Radiol Clin North Am1976; 14:265
17.
Nusbaum M., Baum S.Radiographic demonstration of unknown sites of gastrointestinal bleeding. Surg Forum1963; 14:374-375
18.
Cello JPDiagnosis and management of lower gastrointestinal tract hemorrhage . West J Med1985;143:80-87
19.
Tedesco O., Waye JD, Raskin JB, et al. Colonoscopic evaluation of rectal bleeding. Ann Intern Med1978;89:907-909
20.
Jensen DM, Machicade CAEmergent colonoscopy in patients with severe lower gastrointestinal bleeding (abstract). Gastroenterology1981 ;80:1184
21.
Winzelberg GG, Froelich JW, McKusick KA, et al. Radionuclide localization of lower gastrointestinal hemorrhage. Radiology1981 ;139:465-469
22.
Kester RR, Welch JP, Sziklas JPThe 99m Tc-labeled RBC scan: a diagnostic method for lower gastrointestinal bleeding. Dis Colon Rectum1984;27:47-52
23.
Markisz JA, Font D., Royal HD, et al. An evaluation of 99m Tc-labeled red cell scintigraphy for the detection and localization of gastrointestinal bleeding sites. Gastroenterology1982;83:394-398
24.
Alavi A., Dann RW, Baum S., Biery DNScintigraphic detec- . tion of acute gastrointestinal bleeding. Radiology1977; 124:753-757
25.
Alavi A., McClean GKStudies of GI bleeding with scintigraphy and the influence of vasopressin . Semin Nucl Med1981;11:216-223
26.
Colacchio TA , Forde KA, Patsos TJ, Nunez D.Impact of modern diagnostic methods on the management of active rectal bleeding. Am J Surg1982;143:607-610
27.
Benson RE, Isbister JPMassive blood transfusion. Anaesth Intensive Care1980;8:152-157
28.
Downey SECardiac performance in hemorrhagic shock. Texas Reports Biol Med1979;39:157-169
29.
Berk JL, Hagen JF, Fried NJThe effect of vasopressin on oxygen availability. Ann Surg1979;189:439-441
30.
Conn HO, Ramsby GR, Storer EH, et al. Intraarterial vasopressin in the treatment of upper gastrointestinal hemorrhage : a prospective controlled clinical trial. Gastroenterology1975;68:211-221
31.
Conn HO, Storer EHSelective intraarterial vasopressin in the treatment of upper gastrointestinal hemorrhage. Gastroenterology1972;63:634-645
32.
Sherman LM, Shenoy SS, Cerra FBSelective intra-arterial vasopressin: clinical efficacy and complications . Ann Surg1979;189:298-302
33.
Barr JW, Lakin RC, Rosch J.Similarity of arterial and intravenous vasopressin on portal and systemic hemodynamics. Gastroenterology1975;69:13-19
34.
Chojkier M. , Groszman RJ, Atterbury CE, et al. A controlled _ comparison of continuous intraarterial and intravenous in- ' fusions of vasopressin in hemorrhage from esophageal . varices. Gastroenterology1979 ;77:540-546
35.
Fogel MR, Knauer CM, Andres LL, et al. Continuous intravenous vasopressin in active upper gastrointestinal bleeding. Ann Intern Med1982;96:565-569
Groszmann RJ , Kravetz D., Bosch J., et al. Nitroglycerin improves the hemodynamic response to vasopressin in portal hypertension. Hepatology1982;2:757-762
38.
Freeman JG, Lishman AH, Cobden I., Record COControlled trial of terlipressin ('glypressin') versus vasopressin in the early treatment of oesophageal varices. Lancet1982;2:66-68
39.
Kravetz D., Bosch J., Bruix J., et al. Comparison of intravenous somatostatin and vasopressin infusions in treatment of acute variceal hemorrhage. Hepatology1984;4:442-446
40.
Magnusson I. , Ihre T., Johansson C., et al. Randomised double blind trial of somatostatin in the treatment of massive upper gastrointestinal haemorrhage. Gut1985;26:221-226
41.
Somerville KW , Henry DA, Davies JG, et al. Somatostatin in treatment of hematemesis and melenaLancet1985;1:130-132
42.
Kittang E., Erling A., Oyen D.Effect of peroral antacid treatment in patients with acute upper gastrointestinal haemorrhage : a randomized controlled trial. Scand J Gastroenterol1985;109:112-115
43.
La Brooy SJ , Misiewicz JJ, Edwards J., et al. Controlled trial of cimetidine in upper gastrointestinal hemorrhage. Gut1979 ; 20:892-895
44.
Birnie GG, Quigley MM, Allan G., et al. A double blind randomized trial of cimetidine in acute upper gastrointestinal bleeding. Scand J Gastroenterol1984;19:885-888
45.
Thomson ABR , Maguire T., Wensel RH, et al. Ranitidine versus cimetidine in the management of acute upper gastrointestinal tract bleeding . J Clin Gastroenterol1984;6:295-299
46.
Zuckerman G. , Welch R., Douglas A., et al. Controlled trial of medical therapy for active upper gastrointestinal bleeding and prevention of bleeding. Am J Med1984;76:361-366
47.
Collins R., Langman M.Treatment with histamine H2 antagonists in acute upper gastrointestinal hemorrhage . N Engl J Med1985;313:660-666
48.
Barer D., Ogilvie A., Henry D., et al. Cimetidine and tranexamic acid in treatment of acute upper gastrointestinal tract bleeding. N Engl J Med1983;308:1571-1575
49.
Weiss JB, Peskin GW, Isenberg JITreatment of hemorrhagic gastritis with 15(R)-15-methyl prostaglandin ES12T: report of a case. Gastroenterology1982;82:558-560
50.
Groeger JS, Dazza SJ, Carlon GC, et al. Prostaglandin therapy in a case of refractory stress ulcer bleeding . Crit Care Med1982;10:486-487
51.
Raskin JB, Camara DS, Levine K.Effect of 15(R)-15-methyl prostaglandin E2 on acute upper gastrointestinal hemorrhage (abstract). Gastroenterology1985 ;88:1550
52.
Hastings PR , Skillman fl, Bushnell LS, Silen W.Antacid titration in the prevention of acute gastrointestinal bleeding. N Engl J Med1978 ;298:1041-1045
53.
Priebe HJ, Skillman JJ, Bushnell LS, et al. Antacid versus cimetidine in preventing acute gastrointestinal bleeding. N Engl J Med1980;302:426-430
54.
Macdougall BRD , Bailey RJ, Williams R.H2-receptor antagonists and antacids in the prevention of acute gastrointestinal hemorrhage in fulminant hepatic failure . Lancet1977;1:617-618
55.
Pruitt BA, Goodwin CWStress ulcer disease in the burned patient. World J Surg1981;5:209-222
56.
Skillman U. , Lisbon A., Long PC, Silen W.15(R)-15-methyl prostaglandin E2 does not prevent gastrointestinal bleeding in seriously ill patients. Am J Surg1984;147:451-455
57.
Klein FA, Drueck C., Breuer RI, et al. Control of gastrointestinal bleeding with avitene (abstract) . Gastrointest Endosc1980;26:70
58.
Protell RL, Silverstein FE, Gulacsik C., et al. Failure of cyanoacrylate tissue glue (Flucrylate, MBR4197) to stop bleeding from experimental canine gastric ulcers. Dig Dis Sci1978;23:903-908
59.
Marzuk PM, Schwartz JS: Endoscopic sclerotherapy for esophageal varices. Ann Intern Med1984;100:608-610
60.
Copenhagen Esophageal Varices Sclerotherapy Project: Sclerotherapy after first variceal hemorrhage in cirrhosis. N Engl J Med1984;311:1594-1600
61.
Paquet KJ, Feussner H.Endoscopic sclerosis and esophageal balloon tamponade in acute hemorrhage from esophagogastric varices: a prospective controlled randomized trial. Hepatology1985;5:580-583
62.
Cello JP, Grendell JH, Crass RA, et al. Endoscopic sclerotherapy versus portacaval shunt in patients with severe cirrhosis and variceal hemorrhage. N Engl J Med1984; 311:1589-1593
63.
MacDougall BR, Westaby D., Theodossi A., et al. Increased long-term survival in variceal hemorrhage using injection sclerotherapy: results of a controlled trial. Lancet1982; 1:124-127
64.
Westaby D., Macdougall BRD, Williams R.Improved survival following injection sclerotherapy for esophageal varices: final analysis of a controlled trial. Hepatology1985;5:827-830
65.
Hirao M., Kobayashi T., Masuda K., et al. Endoscopic local injection of hypertonic saline-epinephrine solution to arrest hemorrhage from the upper gastrointestinal tract. Gastrointest Endosc1985;31:313-317
66.
Papp JPElectrocoagulation in upper gastrointestinal bleeding. Dig Dis Sci1981;26(suppl):41s-43s
67.
Protell RL, Gilbert DA, Silverstein FE, et al. Computer-assisted electrocoagulation: bipolar vs monopolar in the treatment of experimental canine gastric ulcer bleeding. Gastroenterology1981;80:451-455
68.
Kernohan RM , Anderson JR, McKelvey STD, Kennedy TLA controlled trial of bipolar electrocoagulation in patients with upper gastrointestinal bleeding. Br J Surg1984;71:889-891
69.
Shorvon PJ, Leung JWC, Cotton PBPreliminary clinical experience with the heat probe at endoscopy in acute upper gastrointestinal bleeding. Gastrointest Endosc1985;31:364-366
70.
Johnston JH , Stones JQ, Long BW, Posey ELComparison of heater probe and YAG laser in endoscopic treatment of major bleeding from peptic ulcers. Gastrointest Endosc1985;31:175-180
71.
Hunter JG, Bowers JH, Burt RW, et al. Lasers in endoscopic surgery. Am J Surg1984;148:736-741
72.
Fleischer D.Endoscopic laser therapy for gastrointestinal disease. Arch Intern Med1984;144:1225-1230
73.
Silverstein FE, Gilbert DA, Auth DCEndoscopic hemostasis using laser photocoagulation and electrocoagulation. Dig Dis Sci1981;26(suppl):31s-40s
74.
Fleischer D.Endoscopic Nd:YAG laser therapy for active esophageal variceal bleeding. Gastrointest Endosc1985 ;31: 4-9