Biostatistics is an increasing focus in current medical school curricula. This study evaluated the statistical methods utilized in a high-impact factor medical Journal to develop a guide to those statistics that can be applied to facilitate the interpretation of data for practicing physicians, fellows, residents, and medical students.
Methods
In Part 1 of our tandem manuscripts, the 100 most recent primary articles from February 2021 to December 2021 were analyzed from the Journal of Intensive Care Medicine. The evaluation consisted of study temporality, study design, types of descriptor variables, and types of statistical tests.
Results
Retrospective studies were most common (75/100, 75%), followed by prospective studies (23/100, 23%). The most popular designs were cohort (82/100, 82%), followed by case series (9/100, 9%), randomized control trials (4/100, 4%), and case-control (3/100, 3%). The most commonly utilized descriptor variables were frequency and proportion (100/100, 100%), followed by median (74/100, 74%) and mean (71/100, 71%). The chi-square test was the most frequently used statistical test (59/100, 59%), while logistic regression (48/100, 48%), Mann-Whitney-U (46/100, 46%), and two-sample independent t-test (40/100, 40%) also were popular.
Conclusion
This review revealed that retrospective and cohort studies were utilized most frequently. The chi-square test was used in the majority of studies, while logistic regression was also popular. This information can help determine areas in which supplemental training will be most beneficial to improve the understanding of statistical methods in medical journals by practicing physicians, fellows, residents, and medical students. As an outgrowth of this study, we have developed a practical guide to relevant statistical methods, serving as Part 2 of these tandem manuscripts.
HaistSAKatsufrakisPJDillonGF. The evolution of the United States Medical Licensing Examination (USMLE): Enhancing assessment of practice-related competencies. JAMA. 2013;310(21):2245-2246. doi:https://doi.org/10.1001/jama.2013.282328
GoldsteinCWoodsNMacKinnonR, et al.Numeracy education for health care providers: A scoping review. J Contin Educ Health Prof. 2024;44(1):35-43. doi: https://doi.org/10.1097/CEH.0000000000000504
6.
Al SulaimanKAljuhaniOAl AamerK, et al.The role of inhaled corticosteroids (ICS) in critically ill patients with COVID-19: A multicenter, cohort study. J Intensive Care Med.2022;37(2):248-257. doi:https://doi.org/10.1177/08850666211053548
7.
AliyuSMcGowanKHussainD, et al.Prevalence and outcomes of multi-drug resistant blood stream infections among nursing home residents admitted to an acute care hospital. J Intensive Care Med.2022;37(4):565-571. doi:https://doi.org/10.1177/08850666211014450
8.
BadjatiaNRyanAChoiHA, et al.Relationship between nutrition intake and outcome after subarachnoid hemorrhage: Results from the international nutritional survey. J Intensive Care Med. 2021;36(10):1141-1148. doi:https://doi.org/10.1177/0885066620966957
9.
BaigSHGorthDJYooEJ. Critical care utilization and outcomes of interhospital medical transfers at lower risk of death. J Intensive Care Med.2022;37(5):679-685. doi:https://doi.org/10.1177/08850666211022613
10.
BaigSHOxmanDAYooEJ. Weekend admission does not confer an increased risk of mortality in septic shock. J Intensive Care Med.2022;37(6):810-816. doi:https://doi.org/10.1177/08850666211038549
11.
BeckerASeilerFMuellenbachRM,et al.Pulmonary hemodynamics and ventilation in patients with COVID-19-related respiratory failure and ARDS. J Intensive Care Med. 2021;36(6):655–663. doi:https://doi.org/10.1177/0885066621995386
12.
BerrillM. Evaluation of oxygenation in 129 proning sessions in 34 mechanically ventilated COVID-19 patients. J Intensive Care Med. 2021;36(2):229-232. doi:https://doi.org/10.1177/0885066620955137
13.
BhargavaASzpunarSMSharmaM, et al.Clinical features and risk factors for in-hospital mortality from COVID-19 infection at a tertiary care medical center, at the onset of the us COVID-19 pandemic. J Intensive Care Med. 2021;36(6):711-718. doi:https://doi.org/10.1177/08850666211001799
14.
BirudarajuDHamalSTayekJA. Solumedrol treatment for severe sepsis in humans with a blunted adrenocorticotropic hormone-cortisol response: A prospective randomized double-blind placebo-controlled pilot clinical trial. J Intensive Care Med.2022;37(5):693-697. doi:https://doi.org/10.1177/08850666211038883
15.
BuckleyJRWibleBC. In-hospital mortality and related outcomes for elevated risk acute pulmonary embolism treated with mechanical thrombectomy versus routine care. J Intensive Care Med.2022;37(7):877-882. doi:https://doi.org/10.1177/08850666211036446
16.
ButtsCWilsonJLasseigneLOralEKabanN. Ultrasound of the optic nerve does not appear to be a consistently reliable or generalizable method to monitor changes in intracranial pressure. J Intensive Care Med.2022;37(5):663-670. doi:https://doi.org/10.1177/08850666211021737
17.
ChandelAPatoliaSLoobyM, et al.Association of D-dimer and fibrinogen with hypercoagulability in COVID-19 requiring extracorporeal membrane oxygenation. J Intensive Care Med. 2021;36(6):689-695. doi:https://doi.org/10.1177/0885066621997039
18.
ChatterjeeKRadyMYVerheijdeJLButterfieldRJ. A framework for revisiting brain death: Evaluating awareness and attitudes toward the neuroscientific and ethical debate around the American academy of neurology brain death criteria. J Intensive Care Med. 2021;36(10):1149-1166. doi:https://doi.org/10.1177/0885066620985827
19.
ChenHXuJWangXWangYTongF. Early lactate-guided resuscitation of elderly septic patients. J Intensive Care Med.2022;37(5):686-692. doi:https://doi.org/10.1177/08850666211023347
20.
ChoiCLennonRJChoiDH, et al.Relationship between body mass index and survival among critically ill patients with cirrhosis. J Intensive Care Med.2022;37(6):817-824. doi:https://doi.org/10.1177/08850666211029827
21.
ChoronRLButtsCABargoudC, et al.Fever in the ICU: A predictor of mortality in mechanically ventilated COVID-19 patients. J Intensive Care Med. 2021;36(4):484-493. doi:https://doi.org/10.1177/0885066620979622
22.
ConnerCMPeruckiWHGabrielAO’SullivanDMFernandezAB. Heart rate and neurological outcomes in patients undergoing targeted temperature management. J Intensive Care Med. 2021;36(12):1392-1397. doi:https://doi.org/10.1177/0885066620982502
23.
CuijpersACMCoolsenMMESchnabelRM, et al.Self-perceived recovery and quality of life in elderly patients surviving ICU-admission for abdominal sepsis. J Intensive Care Med. 2022;37(7):970-978. doi:https://doi.org/10.1177/08850666211052460
24.
CutlerNSSadowskiBWMacGregorDA. Use of lactulose to treat hyperammonemia in ICU patients without chronic liver disease or significant hepatocellular injury. J Intensive Care Med.2022;37(5):698-706. doi:https://doi.org/10.1177/08850666211023004
25.
DichtwaldSMeyerAZoharE, et al.Hypertriglyceridemia induced pancreatitis: Plasmapheresis or conservative management?J Intensive Care Med.2022;37(9):1174-1178. doi:https://doi.org/10.1177/08850666211054365
26.
DijkmanWMvan AchtNMCvan AkkerenJPBhagwanbaliRCDvan PulC. Comparing ventilation parameters for COVID-19 patients using both long-term ICU and anesthetic ventilators in times of shortage. J Intensive Care Med. 2021;36(8):963-971. doi:https://doi.org/10.1177/08850666211024911
27.
Dueñas-CastellCBorre-NaranjoDRodeloD, et al.Changes in oxygenation and clinical outcomes with awake prone positioning in patients with suspected COVID-19 in low-resource settings: A retrospective cohort study. J Intensive Care Med. 2021;36(11):1347-1353. doi:https://doi.org/10.1177/08850666211049333
28.
DuttaAAlirhayimZMasmoudiY, et al.Brain natriuretic peptide as a marker of adverse neurological outcomes among survivors of cardiac arrest. J Intensive Care Med.2022;37(6):803-809. doi:https://doi.org/10.1177/08850666211034728
29.
El-SolhAAMeduriUGLawsonYCarterMMergenhagenKA. Clinical course and outcome of COVID-19 acute respiratory distress syndrome: Data from a national repository. J Intensive Care Med. 2021;36(6):664-672. doi:https://doi.org/10.1177/088506662199 4476
30.
EndeVJSinghGBabatsikosI, et al.Survival of COVID-19 patients with respiratory failure is related to temporal changes in gas exchange and mechanical ventilation. J Intensive Care Med. 2021;36(10):1209-1216. doi:https://doi.org/10.1177/08850666211033836
31.
FeinDGZhaoDSwartzK, et al.The impact of nighttime on first pass success during the emergent endotracheal intubation of critically ill patients. J Intensive Care Med. 2021;36(12):1498-1506. doi:https://doi.org/10.1177/0885066620965166
32.
Fernández-SarmientoJAlcalá-LozanoCBarreraPA, et al.Association between unbalanced solutions and acute kidney injury during fluid resuscitation in children with sepsis. J Intensive Care Med.2022;37(5):625-632. doi:https://doi.org/10.1177/08850666211004453
33.
FrakesMARichardsJBCocchiMN, et al.Critical care transport of patients with COVID-19. J Intensive Care Med. 2021;36(6):704-710. doi:https://doi.org/10.1177/08850666211001797
34.
GabrielRATrivediSSchmidtUH. A point-based risk calculator predicting mortality in patients that developed postoperative sepsis. J Intensive Care Med. 2021;36(12):1443-1449. doi:https://doi.org/10.1177/0885066620960991
35.
GandjianMWilliamsonCXiaY, et al.Association of hospital safety net status with outcomes and resource use for extracorporeal membrane oxygenation in the United States. J Intensive Care Med.2022;37(4):535-542. doi:https://doi.org/10.1177/08850666211007062
36.
GazivodaVPIbrahimMKangas-DickA, et al.Outcomes of barotrauma in critically ill COVID-19 patients with severe pneumonia. J Intensive Care Med. 2021;36(10):1176-1183. doi:https://doi.org/10.1177/08850666211023360
37.
GibsonLEFenzaRDLangM, et al.Right ventricular strain is common in intubated COVID-19 patients and does not reflect severity of respiratory illness. J Intensive Care Med. 2021;36(8):900-909. doi:https://doi.org/10.1177/08850666211006335
38.
GillHSLindgrenESteeleAD, et al.Errors of commission in cardiac arrest care in the intensive care unit. J Intensive Care Med. 2021;36(7):749-757. doi:https://doi.org/10.1177/08850666211018101
39.
GiuseppeDBGiuseppinaNDesireeS, et al.Improving care in neonatal intensive units during the COVID-19 pandemic: A survey on electronic health communication. J Intensive Care Med.2022;37(5):671-678. doi:https://doi.org/10.1177/08850666211055058
40.
GreenwayALeahyNTorrieriL, et al.Skin failure among critically ill patients afflicted with coronavirus disease 2019 (COVID-19). J Intensive Care Med. 2021;36(11):1331-1339. doi:https://doi.org/10.1177/08850666211046532
41.
GuntherMWitenkoCJPrustMSalernoDBergerK. The safety and efficacy of desmopressin in patients with intracranial hemorrhage and a history of alcohol use. J Intensive Care Med.2022;37(6):825-832. doi:https://doi.org/10.1177/08850666211031494
42.
HäberleHMaguniaHLangP, et al.Mesenchymal stem cell therapy for severe COVID-19 ARDS. J Intensive Care Med. 2021;36(6):681-688. doi:https://doi.org/10.1177/0885066621997365
43.
HallAWangXZuegeDJ, et al.Association between afterhours discharge from the intensive care unit and hospital mortality: A multi-center retrospective cohort study. J Intensive Care Med.2022;37(1):134-143. doi:https://doi.org/10.1177/0885066620981902
44.
HansenCKIssaMBalajiL, et al.Performance of the APACHE II and SOFA scores in diabetic ketoacidosis. J Intensive Care Med. 2022;37(6):715-720. doi:https://doi.org/10.1177/08850666211023718
45.
HoKGordonJLitzenbergKT, et al.Cancer is an independent risk factor for acute respiratory distress syndrome in critically ill patients: A single center retrospective cohort study. J Intensive Care Med.2022;37(3):385-392. doi:https://doi.org/10.1177/08850666211005422
46.
HuntMFClarkKTWhitmanG, et al.The use of cerebral NIRS monitoring to identify acute brain injury in patients with VA-ECMO. J Intensive Care Med. 2021;36(12):1403-1409. doi:https://doi.org/10.1177/0885066620966962
47.
IonescuFZimmerMSPetrescuI, et al.Extubation failure in critically ill COVID-19 patients: Risk factors and impact on in-hospital mortality. J Intensive Care Med. 2021;36(9):1018–1024. doi:https://doi.org/10.1177/08850666211020281
48.
JayakumarDRamachandranDnb PRabindrarajanDnb E, et al.Standard care versus awake prone position in adult nonintubated patients with acute hypoxemic respiratory failure secondary to COVID-19 infection - A multicenter feasibility randomized controlled trial. J Intensive Care Med. 2021;36(8):918-924. doi:https://doi.org/10.1177/08850666211014480
49.
JentzerJCAlviarCLMillerPE, et al.Trends in therapy and outcomes associated with respiratory failure in patients admitted to the cardiac intensive care unit. J Intensive Care Med.2022;37(4):543-554. doi:https://doi.org/10.1177/08850666211003489
50.
KahnMRWatsonRLThetfordJTWongJIKamangarN. High incidence of barotrauma in patients with severe coronavirus disease 2019. J Intensive Care Med. 2021;36(6):646-654. doi:https://doi.org/10.1177/0885066621989959
51.
KalraSSJaberJAlzghoulBN, et al.Pre-existing psychiatric illness is associated with an increased risk of delirium in patients with acute respiratory distress syndrome. J Intensive Care Med.2022;37(5):647-654. doi:https://doi.org/10.1177/08850666211019009
52.
KapoorSChandSDieievV, et al.Thromboembolic events and role of point of care ultrasound in hospitalized COVID-19 patients needing intensive care unit admission. J Intensive Care Med. 2021;36(12):1483-1490. doi:https://doi.org/10.1177/0885066620964392
53.
KappCMLatifiAFeller-KopmanD, et al.Sedation and analgesia in patients undergoing tracheostomy in COVID-19, a multi-center registry. J Intensive Care Med.2022;37(2):240-247. doi:https://doi.org/10.1177/08850666211045896
54.
KimSMKimSIYuG, et al.Hypercoagulability in septic shock patients with thrombocytopenia. J Intensive Care Med.2022;37(6):721-727. doi:https://doi.org/10.1177/08850666211024188
55.
KingDDavisonDBenjenkI, et al.YouTube to teach central lines, the expert vs learner perspective. J Intensive Care Med.2022;37(4):528-534. doi:https://doi.org/10.1177/0885066621999979
56.
KoJJWuCMehtaN, et al.A comparison of methylprednisolone and dexamethasone in intensive care patients with COVID-19. J Intensive Care Med. 2021;36(6):673-680. doi:https://doi.org/10.1177/0885066621994057
57.
KoppurapuVSPuliaievMDoerschugKCSchmidtGA. Ventilated patients with COVID-19 show airflow obstruction. J Intensive Care Med. 2021;36(6):696-703. doi:https://doi.org/10.1177/08850666211000601
58.
KrasseltMBaerwaldCPetrosSSeifertO. Sepsis mortality is high in patients with connective tissue diseases admitted to the intensive care unit (ICU). J Intensive Care Med.2022;37(3):401-407. doi:https://doi.org/10.1177/0885066621996257
59.
KrutsingerDCHetlandBDO’LearyKLHalpernSDCourtrightKR. A qualitative analysis of factors influencing critical care trial enrollment among surrogates. J Intensive Care Med.2022;37(3):430-434. doi:https://doi.org/10.1177/0885066621998978
60.
LaBuzettaJNHirshmanBRMalhotraAOwensRLKamdarBB. Practices and patterns of hourly neurochecks: analysis of 8,936 patients with neurological injury. J Intensive Care Med.2022;37(6):784-792. doi:https://doi.org/10.1177/08850666211029220
61.
Lazar NetoFSousaLGLewisWE, et al.Outcomes of critically ill lung cancer patients initiating targeted therapy or immunotherapy in the intensive care unit: A single-center report. J Intensive Care Med.2022;37(8):1055-1059. doi:https://doi.org/10.1177/08850666211061312
62.
LewAMorrisonJMAmankwahESochetAA. Heliox for pediatric critical asthma: A multicenter, retrospective, registry-based descriptive study. J Intensive Care Med.2022;37(6):776-783. doi:https://doi.org/10.1177/08850666211026550
63.
MahmoudOPatadiaDSaloniaJ. Utilization of airway pressure release ventilation as a rescue strategy in COVID-19 patients: A retrospective analysis. J Intensive Care Med. 2021;36(10):1194-1200. doi:https://doi.org/10.1177/08850666211030899
64.
MastroianniFLeismanDEFislerGNarasimhanM. General and intensive care outcomes for hospitalized patients with solid organ transplants with COVID-19. J Intensive Care Med. 2021;36(4):494-499. doi:https://doi.org/10.1177/0885066620965163
65.
MayADParkerAMCaldwellES, et al.Provider-documented anxiety in the ICU: Prevalence, risk factors, and associated patient outcomes. J Intensive Care Med. 2021;36(12):1424–1430. doi:https://doi.org/10.1177/0885066620956564
66.
MorochoJPMartínezAFCevallosMM, et al.Prolonged capillary refilling as a predictor of mortality in patients with septic shock. J Intensive Care Med.2022;37(3):423-429. doi:https://doi.org/10.1177/08850666211003507
67.
NaarLHechiMWEGallastegiAD, et al.Intensive care unit volume of sepsis patients does not affect mortality: Results of a nationwide retrospective analysis. J Intensive Care Med.2022;37(6):728-735. doi:https://doi.org/10.1177/08850666211024184
68.
NaendrupJHBorregaJGDennisAE, et al.Reactivation of EBV and CMV in severe COVID-19-epiphenomena or trigger of hyperinflammation in need of treatment? A large case series of critically ill patients. J Intensive Care Med.2022;37(9):1152-1158. doi:https://doi.org/10.1177/08850666211053990
69.
ObergCLKeyesCPanchabhaiTS, et al.Combined percutaneous tracheostomy and endoscopic gastrostomy tubes in COVID-19: A prospective series of patient outcomes. J Intensive Care Med. 2021;36(11):1340-1346. doi:https://doi.org/10.1177/08850666211038875
70.
OgicaABurdelskiCRohdeHKlugeSde HeerG. Necrotizing soft tissue infections in intensive care. J Intensive Care Med.2022;37(3):393-400. doi:https://doi.org/10.1177/08850666211010127
71.
OhTKParkHYSongIA. Delirium and long-term outcomes among survivors of extracorporeal membrane oxygenation therapy: A nationwide cohort study in South Korea. J Intensive Care Med.2022;37(7):870-876. doi:https://doi.org/10.1177/08850666211032610
72.
OtusanyaOTHsiehSJGongMNGershengornHB. Impact of ABCDE bundle implementation in the intensive care unit on specific patient costs. J Intensive Care Med.2022;37(6):833-841. doi:https://doi.org/10.1177/08850666211031813
73.
PadkinsMBreenTAnavekarN, et al.Association between albumin level and mortality among cardiac intensive care unit patients. J Intensive Care Med. 2021;36(12):1475-1482. doi:https://doi.org/10.1177/0885066620963875
74.
PengFLiangCChangW, et al.Prognostic significance of plasma hepatocyte growth factor in sepsis. J Intensive Care Med.2022;37(3):352-358. doi:https://doi.org/10.1177/0885066621993423
75.
QiuYSesslerDIChenL, et al.Preoperative vitamin d deficiency is associated with postoperative delirium in critically ill patients. J Intensive Care Med.2022;37(5):655-662. doi:https://doi.org/10.1177/08850666211021330
76.
QuraishiSABhanIMatthayMA, et al.Vitamin D status and clinical outcomes in acute respiratory distress syndrome: a secondary analysis from the assessment of low tidal volume and elevated end-expiratory volume to obviate lung injury (ALVEOLI) trial. J Intensive Care Med.2022;37(6):793-802. doi:https://doi.org/10.1177/08850666211028139
77.
RaasveldSJDelnoijTSRBromanLM, et al.Extracorporeal membrane oxygenation in patients with COVID-19: An international multicenter cohort study. J Intensive Care Med. 2021;36(8):910-917. doi:https://doi.org/10.1177/08850666211007063
78.
RajdevKSpanelAJMcMillanS, et al.Pulmonary barotrauma in COVID-19 patients with ARDS on invasive and non-invasive positive pressure ventilation. J Intensive Care Med. 2021;36(9):1013-1017. doi:https://doi.org/10.1177/08850666211019719
79.
ReardonPMSeelyAJEFernandoSM, et al.Can early warning systems enhance detection of high risk patients by rapid response teams?J Intensive Care Med. 2021;36(5):542-549. doi:https://doi.org/10.1177/0885066620978140
80.
ReisAEEmamiNChandS, et al.Epidemiology, risk factors and outcomes of pneumomediastinum in patients with coronavirus disease 2019: A case-control study. J Intensive Care Med.2022;37(1):12-20. doi:https://doi.org/10.1177/08850666211040417
81.
ReisSPBrejtSZWeintraubJR, et al.Percutaneous ultrasound guided gastrostomy tube placement: A prospective cohort trial. J Intensive Care Med.2022;37(5):641-646. doi:https://doi.org/10.1177/08850666211015595
82.
RisaERoachDBudakJZ, et al.Characterization of secondary bacterial infections and antibiotic use in mechanically ventilated patients with COVID-19 induced acute respiratory distress syndrome. J Intensive Care Med. 2021;36(10):1167-1175. doi:https://doi.org/10.1177/08850666211021745
83.
RitterLABrittonNHeilEL, et al.The impact of corticosteroids on secondary infection and mortality in critically ill COVID-19 patients. J Intensive Care Med. 2021;36(10):1201-1208. doi:https://doi.org/10.1177/08850666211032175
84.
ShahAXuJFriedmanS, et al.Comparative analysis of intravenous pumps relocation for critically ill isolated COVID-19 patients from bedside to outside the patient room. J Intensive Care Med. 2021;36(6):719-725. doi:https://doi.org/10.1177/0885066621989920
85.
ShelhamerMCWessonPDSolariIL, et al.Prone positioning in moderate to severe acute respiratory distress syndrome due to COVID-19: A cohort study and analysis of physiology. J Intensive Care Med. 2021;36(2):241-252. doi:https://doi.org/10.1177/0885066620980399
86.
ShenYHuangXCaiG, et al.Impact of fluid balance on mortality is mediated by fluid accumulation index in sepsis: A cohort study. J Intensive Care Med. 2021;36(12):1458-1465. doi:https://doi.org/10.1177/0885066620960626
87.
SilverLJKesselATaurassiCTaylorM. The effect of the coronavirus-2019 pandemic on pediatric critical care fellowship training. J Intensive Care Med.2022;37(3):366-372. doi:https://doi.org/10.1177/08850666211043058
88.
SmallCAttridgeRLFranco-MartinezCDonnellyJBartholC. Prothrombin complex concentrate use in intracranial hemorrhage patients with cirrhosis not on prior anticoagulation. J Intensive Care Med.2022;37(5):633-640. doi:https://doi.org/10.1177/08850666211012650
89.
SmischneyNJKhannaAKBrauerE, et al.Risk factors for and outcomes associated with peri-intubation hypoxemia: A multicenter prospective cohort study. J Intensive Care Med. 2021;36(12):1466-1474. doi:https://doi.org/10.1177/0885066620962445
90.
SongWMobliKJupiterDCRadhakrishnanRS. CVP and echo measurements are associated with improved outcomes in patients with gastrointestinal (GI) hemorrhage: a retrospective analysis of the MIMIC- IV database. J Intensive Care Med.2022;37(7):925-935. doi:https://doi.org/10.1177/08850666211046175
91.
SontiRPikeCWCobbN. Responsiveness of inhaled epoprostenol in respiratory failure due to COVID-19. J Intensive Care Med. 2021;36(3):327-333. doi:https://doi.org/10.1177/0885066620976525
92.
SoodRNPalleikoBAAlape-MoyaD, et al.COVID-19 tracheostomy: Experience in a university hospital with intermediate follow-up. J Intensive Care Med. 2021;36(12):1507-1512. doi:https://doi.org/10.1177/08850666211043436
93.
StahlKBikkerRSeeligerB, et al.Effect of therapeutic plasma exchange on immunoglobulin deficiency in early and severe septic shock. J Intensive Care Med. 2021;36(12):1491-1497. doi:https://doi.org/10.1177/0885066620965169
94.
SteyAMKanzariaHKDudleyRA, et al.Emergency department length of stay and mortality in critically injured patients. J Intensive Care Med.2022;37(2):278-287. doi:https://doi.org/10.1177/0885066621995426
95.
TabiMBursteinBJAnavekarNSKashaniKBJentzerJC. Associations of vasopressor requirements with echocardiographic parameters after out-of-hospital cardiac arrest. J Intensive Care Med.2022;37(4):518-527. doi:https://doi.org/10.1177/0885066621998936
96.
TillmannBWNathensABScalesDCHaasB. Association between intoxication and urgent neurosurgical procedures in severe traumatic brain injury: Results from the American College of Surgeons trauma quality improvement program. J Intensive Care Med.2022;37(3):373-384. doi:https://doi.org/10.1177/08850666211017497
97.
TsouPYYoCHHseinYC, et al.Temporal trends in the microbiological characteristics of sepsis in the United States: A population based study. J Intensive Care Med.2022;37(7):936-945. doi:https://doi.org/10.1177/08850666211053778
98.
van der ZeeENTermorshuizenFBenoitDD, et al.One-year mortality of cancer patients with an unplanned ICU admission: A cohort analysis between 2008 and 2017 in The Netherlands. J Intensive Care Med.2022;37(9):1165-1173. doi:https://doi.org/10.1177/08850666211054369
99.
WatkinsLADialSPKoenigSJKurepaDNMayoPH. The utility of point-of-care ultrasound in the pediatric intensive care unit. J Intensive Care Med.2022;37(8):1029-1036. doi:https://doi.org/10.1177/08850666211047824
100.
Wendel GarciaPDHofmaennerDABruggerSD, et al.Closed-loop versus conventional mechanical ventilation in COVID-19 ARDS. J Intensive Care Med. 2021;36(10):1184-1193. doi:https://doi.org/10.1177/08850666211024139
101.
WrayTCJohnsonMCluffS, et al.Transesophageal echocardiography performed by intensivist and emergency physicians-A 5-year, single-center experience. J Intensive Care Med.2022;37(7):917-924. doi:https://doi.org/10.1177/08850666211042522
102.
XuJXieJDuB, et al.Clinical characteristics and outcomes of patients with severe COVID-19 induced acute kidney injury. J Intensive Care Med. 2021;36(3):319-326. doi:https://doi.org/10.1177/0885066620970858
103.
XuanWJiangXHuangL, et al.Predictive value of eosinophil count on COVID-19 disease progression and outcomes, a retrospective study of Leishenshan Hospital in Wuhan, China. J Intensive Care Med.2022;37(3):359-365. doi:https://doi.org/10.1177/08850666211037326
104.
YasukawaKMinamiTBoulwareDRShimadaAFischerEA. Point-of-care lung ultrasound for COVID-19: Findings and prognostic implications from 105 consecutive patients. J Intensive Care Med. 2021;36(3):334-342. doi:https://doi.org/10.1177/0885066620988831
105.
YunJHHongSBJungSH, et al.Epidemiology and clinical characteristics of bloodstream infection in patients under extracorporeal membranous oxygenation. J Intensive Care Med. 2021;36(9):1053-1060. doi:https://doi.org/10.1177/0885066620985538
106.
BowersD. Medical statistics from scratch: An introduction for health professionals. 4th ed. Wiley; 2020.
107.
ArnoldLDBraganzaMSalihRColditzGA. Statistical trends in the journal of the American medical association and implications for training across the continuum of medical education. PLoS One. 2013;8(10):e77301. Published 2013 Oct 30. doi:https://doi.org/10.1371/journal.pone.0077301
108.
WindishDMHuotSJGreenML. Medicine Residents’ understanding of the biostatistics and results in the medical literature. JAMA. 2007;298(9):1010-1022. doi:https://doi.org/10.1001/jama.298.9.1010
109.
BestAMLaskinDM. Oral and maxillofacial surgery residents have poor understanding of biostatistics. J Oral Maxillofac Surg. 2013;71(1):227-234. doi:https://doi.org/10.1016/j.joms.2012.03.010
110.
CollinsAPMcCallMCassinatJ, et al.Performance of orthopaedic shoulder and elbow surgeons on a biostatistical knowledge examination. Adv Orthop. 2023;2023:8840263. Published 2023 Sep 11. doi:https://doi.org/10.1155/2023/8840263
111.
JohnstonBCAlonso-CoelloPFriedrichJO, et al.Do clinicians understand the size of treatment effects? A randomized survey across 8 countries. CMAJ. 2016;188(1):25-32. doi:https://doi.org/10.1503/cmaj.150430
112.
MavrosMNAlexiouVGVardakasKZFalagasME. Understanding of statistical terms routinely used in meta-analyses: An international survey among researchers. PLoS One. 2013;8(1):e47229. doi:https://doi.org/10.1371/journal.pone.0047229
113.
BartlettGGagnonJ. Physicians and knowledge translation of statistics: Mind the gap. CMAJ. 2016;188(1):11-12. doi:https://doi.org/10.1503/cmaj.151254
114.
AlifierisECSouferiCETrafalisTDArvelakisA. The arbitrary magic of p<0.05: Beyond statistics. J BUON.2020;25(2):588–593.
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