Selective Decontamination of the Digestive Tract and Ventilator-Associated Pneumonia: We Cannot Let Misinformation Go Uncorrected

Davis KA Ventilator-associated pneumonia: a review. J Intensive Care Med. 2006;21:211-226.

Liberati A. , D'Amico R. , Pifferi S. , Torri V. , Brazzi L. Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care. Cochrane Database Syst Rev. 2004: CD000022.

van Saene Hkf , Silvestri L. , de la Cal MA , Sarginson RE Selective decontamination of the digestive tract reduces lower airway and bloodstream infection and mortality and prevents emergence of antimicrobial resistance. Microbes Infect. 2006;8:953-954.

Vandenbroucke-Grauls Cmj , Vandenbroucke JP Effect of selective decontamination of the digestive tract on respiratory tract infections and mortality in the intensive care unit. Lancet. 1991;338:859-862.

Selective Decontamination of the Digestive Tract Trialists' Collaborative Group. Meta-analysis of randomized controlled trials of selective decontamination of the digestive tract. BMJ. 1993;307:525-532.

Kollef M. The role of selective digestive tract decontamination on mortality and respiratory tract infections: a meta-analysis. Chest. 1994;105:1101-1108.

Heyland DK , Cook DJ , Jaeschke R. , Griffith L. , Lee HN , Guyatt GH Selective decontamination of the digestive tract: an overview. Chest. 1994;105:1221-1229.

Hurley JC Prophylaxis with enteral antibiotics in ventilated patients: selective decontamination or selective cross-infection? Antimicrob Agents Chemother. 1995;39:941-947.

D'Amico R. , Pifferi S. , Leonetti C. , Torri V. , Tinazzi A. , Liberati A. Effectiveness of antibiotic prophylaxis in critically ill adult patients: systematic review of randomized controlled trials. BMJ. 1998;316:1275-1285.

Nathens AB , Marshall JC Selective decontamination of the digestive tract in surgical patients: systematic review of the evidence. Arch Surg. 1999;134:170-176.

Redman R. , Ludington E. , Crocker M. , Wittes J. , Bellm L. , Carlet J. , and the VAP Advisory Group. Analysis of respiratory and non-respiratory infections in published trials of selective digestive decontamination. Intensive Care Med. 2001;27(suppl 1):S128.

Safdar N. , Said A. , Lucey MR The role of selective digestive decontamination for reducing infection in patients undergoing liver transplantation: a systematic review and meta-analysis . Liver Transpl. 2004;10:817-827.

Silvestri L. , van Saene HKF , Milanese M. , Gregori D. Impact of selective decontamination of the digestive tract on fungal carriage and infection: systematic review of randomized controlled trials. Intensive Care Med. 2005;31:898-910.

Silvestri L. , Milanese M. , Durì D. , Gregori D. , Gullo A. , van Saene HKF. Impact of SDD on bloodstream infections: a systematic review of randomized trials. Intensive Care Med. 2005;31(suppl 1):S87.

Brun-Buisson C. , Legrand P. , Rauss A. , et al. Intestinal decontamination for control of nosocomial multiresistant gram-negative bacilli. Study of an outbreak in an intensive care unit. Ann Intern Med. 1989 ;110:873-881.

de Jonge E. , Schultz MJ , Spanjaard L. , Bossuyt Pmm , Vroom MB , Dankert J. Effects of selective decontamination of the digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomized trial. Lancet. 2003;362: 1011-1016.

Silvestri L. , van Saene HKF. Selective decontamination of the digestive tract does not increase resistance in critically ill patients: evidence from randomized controlled trials. Crit Care Med. 2006; 34:2027-2030.

Silvestri L. , Petros AJ , Viviani M. , Rommes JH , van Saene HKF. Selective decontamination of the digestive tract and ventilator associated pneumonia (part 1). Respir Care. 2006;51:67-69.

Heininger A. , Mayer E. , Schwab F. , Marschal M. , Unertl K. , Krueger WA Effects of long-term use of selective decontamination on antimicrobial resistance. Intensive Care Med. 2006; 32:1569-1576.

Silvestri L. , van Saene Hkf , de la Cal MA , Gullo A. Adult hospital and ventilator-associated pneumonia guidelines: eminence rather than evidence based. Am J Respir Crit Care Med. 2006;173:131-133.

Silvestri L. , Milanese M. , Oblach L. , et al. Enteral vancomycin to control methicillin-resistant Staphylococcus aureus outbreak in mechanically ventilated patients. Am J Infect Control. 2002;30:391-399.

de la Cal MA , Cerda E. , van Saene HK , et al. Effectiveness and safety of enteral vancomycin to control endemicity of methicillin-resistant Staphylococcus aureus in a medical/ surgical intensive care unit. J Hosp Infect. 2004;56:175-183.

Viviani M. , van Saene Hkf , Dezzoni R. , et al. Control of imported and acquired methicillin-resistant Staphylococcus aureus (MRSA) in mechanically ventilated patients: a dose response study of enteral vancomycin to reduce absolute carriage and infection. Anaesth Intensive Care. 2005;33:361-372.

Sanchez M. , Mir N , Canton R , et al. The effect of topical vancomycin on acquisition, carriage and infection with methicillin-resistant Staphylococcus aureus in critically ill patients. A double-blind, randomized, placebo-controlled study. 37th Interscience Conference of Antimicrobial Agents and Chemotherapy , 1007, Toronto, Canada, Abstract J-119. Herndon, Va: ASM Press; 1997:310.

Silvestri L. , van Saene HKF , Milanese M. , et al. Prevention of MRSA pneumonia by oral vancomycin decontamination: a randomized trial. Eur Respir J. 2004;23:921-926.

Arnow PM , Carandang GR , Zabner R. , Irwin ME Randomized controlled trial of selective bowel decontamination for prevention of infections following liver transplantation. Clin Infect Dis. 1996;22:997-1003.

Hellinger WC , Yao JD , Alvarez S. , et al. A randomized, prospective, double-blind evaluation of selective bowel decontamination in liver transplantation. Transplantation. 2002;73:1904-1909.

van Saene Hkf , Silvestri L. , de la Cal MA , Zandstra DF Selective decontamination of the digestive tract and ventilator associated pneumonia (part 2). Respir Care. 2006;51:72-75.