Nutrition management of patients undergoing a hematopoietic stem cell transplant (HSCT) can be challenging. Fluid, macronutrient, and micronutrient needs are often altered due to a variety of therapy-associated complications and changes in metabolism. Sinusoidal obstructive syndrome (SOS) is a complication characterized by fluid retention, ascites, and painful hepatomegaly that may complicate provision of adequate nutrition to HSCT patients. The nutrition implications and interventions in a patient who developed SOS following an allogeneic matched unrelated donor (Allo/MUD) HSCT are reviewed in the case report.
CarrerasEDiaz-BeyaMRosinolLMartinezC. The incidence of veno-occlusive disease following allogeneic hematopoietic stem cell transplantation has diminished and the outcome improved over the last decade. Biol Blood Marrow Transplant. 2011;17:1698-1720.
2.
McDonaldGB. Hepatobiliary complications of hematopoietic cell transplantation, 40 years on. Hepatology. 2010;51(4):1450-1460.
3.
PlatzbeckerUBornhauserM. SOS for veno-occlusive disease: defibrotide prophylaxis. Lancet. 2012;379(9823):1277-1278.
4.
MuscaritoliMGriecoGCapriaSLoriAPFanelliFR. Nutritional and metabolic support in patients undergoing marrow transplantation. Am J Clin Nutr. 2002;75:183-190.
5.
RichardsonPGSoifferRJAntinJH. Defibrotide for the treatment of severe hepatic veno-occlusive disease and multiorgan failure after stem cell transplantation: a multicenter, randomized, dose-finding trial. Biol Blood Marrow Transplant. 2010;16:1005-1017.
6.
PlessierARautouPEVallaDC. Management of hepatic vascular diseases. J Hepatol. 2012;56(suppl 1):S25-S38.
7.
CoppellJARichardsonPGSoifferR. Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome. Biol Blood Marrow Transplant. 2010;16:157-168.
8.
LipkinACLenssenPDicksonBJ. Nutrition issues in hematopoietic stem cell transplantation: state of the art. Nutr Clin Pract. 2005;20:423-439.
9.
HelmyA. Review article: updates in the pathogenesis and therapy of hepatic sinusoidal obstruction syndrome. Aliment Pharmacol Ther. 2005;23:11-25.
10.
WidlickaAReynoldsV. Indications for nutrition support in hematopoietic stem cell transplant patients. Support Line. 2012;34:2-12.
11.
CharuhasPM. Hematopoietic Stem Cell Transplantation Nutrition Care Criteria. 2nd ed.Seattle, WA: Seattle Cancer Care Alliance; 2002.
12.
KumpfVJGervasioJ. Complications of parenteral nutrition. In: GottschlichMMDeLeggeMHGuenterP eds. The A.S.P.E.N Nutrition Support Core Curriculum: A Case-Based Approach—The Adult Patient. 2nd ed.Silver Spring, MD: American Society for Parenteral and Enteral Nutrition; 2007;323-340.
13.
RobienK. Hematologic malignancies. In: MarianMRobertsS, eds. Clinical Nutrition for Oncology Patients. Sudbury, MA: Jones & Bartlett; 2010:297-321.
CornelissenJJvan der HoltBVerhoefGE. Myeloablative allogeneic versus autologous stem cell transplantation in adult patients with acute lymphoblastic leukemia in first remission: a prospective sibling donor versus no-donor comparison. Blood. 2009;113(6):1375-1382.
16.
ElliotLMolseedLLMcCallumPD. The Clinical Guide to Oncology Nutrition. 2nd ed.Chicago, IL: American Dietetic Association; 2006.
