Folate: Is Too Much of a Good Thing Harmful?

Blom HJ , Smulders Y. Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects [published online ahead of print September4, 2010]. J Inherit Metab Dis.

Sheikh SS Coronary heart disease, genes not to be blamed totally!J Pak Med Assoc. 2010;60:698.

Bailey LB Folate and vitamin B12 recommended intakes and status in the United States . Nutr Rev.2004;62(6pt2):S14-S20; discussion S21.

Konings EJ , Roomans HH , Dorant E. , Goldbohm RA , Saris WH , van den Brandt PA Folate intake of the Dutch population according to newly established liquid chromatography data for foods. Am J Clin Nutr. 2001;73:765-776.

Troen AM , Shukitt-Hale B. , Chao WH , et al. The cognitive impact of nutritional homocysteinemia in apolipoprotein-E deficient mice. J Alzheimers Dis. 2006;9:381-392.

Quinlivan EP , Gregory Jfiii. Effect of food fortification on folic acid intake in the United States. Am J Clin Nutr. 2003;77:221-225.

Lanska DJ Historical aspects of the major neurological vitamin deficiency disorders: the water-soluble B vitamins. Handb Clin Neurol. 2009;95:445-476.

Matthews RG , Kaufman S. Characterization of the dihydropterin reductase activity of pig liver methylenetetrahydrofolate reductase. J Biol Chem. 1980;255:6014-6017.

Morris MC , Evans DA , Schneider JA , Tangney CC , Bienias JL , Aggarwal NT Dietary folate and vitamins B-12 and B-6 not associated with incident Alzheimer’s disease. J Alzheimers Dis. 2006; 9:435-443.

Morris MS , Jacques PF , Rosenberg IH , Selhub J. Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr. 2007;85:193-200.

Morris MC , Evans DA , Bienias JL , et al. Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. Arch Neurol. 2005;62:641-645.

Schnyder G. , Roffi M. , Flammer Y. , Pin R. , Hess OM Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial . JAMA. 2002;288:973-979.

Lange H. , Suryapranata H. , De Luca G. , et al. Folate therapy and in-stent restenosis after coronary stenting . N Engl J Med. 2004; 350:2673-2681.

Toole JF , Malinow MR , Chambless LE , et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA. 2004;291:565-575.

Troen AM , Mitchell B. , Sorensen B. , et al. Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr. 2006;136:189-194.

Kim YI Nutritional epigenetics: impact of folate deficiency on DNA methylation and colon cancer susceptibility. J Nutr. 2005; 135:2703-2709.

Kim YI Will mandatory folic acid fortification prevent or promote cancer? Am J Clin Nutr. 2004;80:1123-1128.

Kim YI Folate, colorectal carcinogenesis, and DNA methylation: lessons from animal studies. Environ Mol Mutagen. 2004;44:10-25.

Kim YI Does a high folate intake increase the risk of breast cancer? Nutr Rev. 2006;64:468-475.

Hultdin J. , Van Guelpen B. , Bergh A. , Hallmans G. , Stattin P. Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study. Int J Cancer. 2005;113:819-824.

Khanna D. , Park GS , Paulus HE , et al. Reduction of the efficacy of methotrexate by the use of folic acid: post hoc analysis from two randomized controlled studies. Arthritis Rheum. 2005;52:3030-3038.

Ebbing M. , Bønaa KH , Nygård O. , et al. Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA. 2009;302:2119-2126.

Cole BF , Baron JA , Sandler RS , et al. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA. 2007; 97:2351-2359.

Nzila A. , Ward SA , Marsh K. , Sims PF , Hyde JE Comparative folate metabolism in humans and malaria parasites (part II): activities as yet untargeted or specific to Plasmodium. Trends Parasitol . 2005; 21:334-339.

McGuire JJ Anticancer antifolates: current status and future directions. Curr Pharm Des. 2003;9:2593-2613.

Salim A. , Tan E. , Ilchyshyn A. , Berth-Jones J. Folic acid supplementation during treatment of psoriasis with methotrexate: a randomized, double-blind, placebo-controlled trial. Br J Dermatol. 2006;154:1169-1174.

Carter JY , Lollpapit MP , Lema OE , Tome JL , Nagelkerke NJ , Watkins WM Reduction of the efficacy of antifolate antimalarial therapy by folic acid supplementation. Am J Trop Med Hyg. 2005; 73:166-170.

Zhao R. , Goldman ID Resistance to antifolates. Oncogene. 2003;22:7431-7457.

Chattopadhyay S. , Tamari R. , Min SH , Zhao R. , Tsai E. , Goldman ID Commentary: a case for minimizing folate supplementation in clinical regimens with pemetrexed based on the marked sensitivity of the drug to folate availability. Oncologist. 2007 ;12: 808-815.

Jänne PA , Mayer RJ Chemoprevention of colorectal cancer. N Engl J Med. 2000;342:1960-1968.

Kim YI Folate and colorectal cancer: an evidence-based critical review. Mol Nutr Food Res. 2007;51:267-292.

Mason JB , Dickstein A. , Jacques PF , et al. A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev . 2007;16: 1325-1329.

Stolzenberg-Solomon RZ , Chang SC , Leitzmann MF Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am J Clin Nutr. 2006;83:895-904.

Oaks BM , Dodd KW , Meinhold CL , Jiao L. , Church TR , Stolzenberg-Solomon RZ Folate intake, post-folic acid grain fortification, and pancreatic cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial . Am J Clin Nutr. 2010;91:449-455.

van der Heijden JW , Oerlemans R. , Dijkmans BA , et al. Folate receptor beta as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients. Arthritis Rheum. 2009;60:12-21.

Cakmak SK , Gül U. , Kiliç C. , Gönül M. , Soylu S. , Kiliç A. Homocysteine, vitamin B12 and folic acid levels in psoriasis patients. J Eur Acad Dermatol Venereol. 2009;23:300-303.

Half of Americans use vitamins and dietary supplements every day; Western Europe is more skeptical. Nielson.com. http://en-us.nielsen.com/content/nielsen/en_us/insights/consumer_insight/issue_16/half_of_americans.html. Accessed November 8, 2010.

Sixty percent of Americans take a multivitamin so why do all disease indices continue to rise? March 20, 2008. http://www.articlesbase.com/health-articles/sixty-percent-of-americans-take-a-multivitamin-so-why-do-all-disease-indices-continue-to-rise-365239.html . Accessed November 8, 2010.