Blom HJ, Smulders Y.Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects [published online ahead of print September4, 2010]. J Inherit Metab Dis.
2.
Sheikh SSCoronary heart disease, genes not to be blamed totally!J Pak Med Assoc. 2010;60:698.
3.
Bailey LBFolate and vitamin B12 recommended intakes and status in the United States . Nutr Rev.2004;62(6pt2):S14-S20; discussion S21.
4.
Konings EJ, Roomans HH, Dorant E., Goldbohm RA, Saris WH, van den Brandt PAFolate intake of the Dutch population according to newly established liquid chromatography data for foods. Am J Clin Nutr. 2001;73:765-776.
5.
Troen AM, Shukitt-Hale B., Chao WH, et al. The cognitive impact of nutritional homocysteinemia in apolipoprotein-E deficient mice. J Alzheimers Dis. 2006;9:381-392.
6.
Quinlivan EP, Gregory Jfiii.Effect of food fortification on folic acid intake in the United States. Am J Clin Nutr. 2003;77:221-225.
7.
Lanska DJHistorical aspects of the major neurological vitamin deficiency disorders: the water-soluble B vitamins. Handb Clin Neurol. 2009;95:445-476.
8.
Matthews RG, Kaufman S.Characterization of the dihydropterin reductase activity of pig liver methylenetetrahydrofolate reductase. J Biol Chem. 1980;255:6014-6017.
9.
Morris MC, Evans DA, Schneider JA, Tangney CC, Bienias JL, Aggarwal NTDietary folate and vitamins B-12 and B-6 not associated with incident Alzheimer’s disease. J Alzheimers Dis. 2006; 9:435-443.
10.
Morris MS, Jacques PF, Rosenberg IH, Selhub J.Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr. 2007;85:193-200.
11.
Morris MC, Evans DA, Bienias JL, et al. Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. Arch Neurol. 2005;62:641-645.
12.
Schnyder G. , Roffi M., Flammer Y., Pin R., Hess OMEffect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial . JAMA. 2002;288:973-979.
13.
Lange H., Suryapranata H., De Luca G., et al. Folate therapy and in-stent restenosis after coronary stenting . N Engl J Med. 2004; 350:2673-2681.
14.
Toole JF, Malinow MR, Chambless LE, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA. 2004;291:565-575.
15.
Troen AM, Mitchell B., Sorensen B., et al. Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr. 2006;136:189-194.
16.
Kim YINutritional epigenetics: impact of folate deficiency on DNA methylation and colon cancer susceptibility. J Nutr. 2005; 135:2703-2709.
17.
Kim YIWill mandatory folic acid fortification prevent or promote cancer? Am J Clin Nutr. 2004;80:1123-1128.
18.
Kim YIFolate, colorectal carcinogenesis, and DNA methylation: lessons from animal studies. Environ Mol Mutagen. 2004;44:10-25.
19.
Kim YIDoes a high folate intake increase the risk of breast cancer? Nutr Rev. 2006;64:468-475.
20.
Hultdin J., Van Guelpen B., Bergh A., Hallmans G., Stattin P.Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study. Int J Cancer. 2005;113:819-824.
21.
Khanna D., Park GS, Paulus HE, et al. Reduction of the efficacy of methotrexate by the use of folic acid: post hoc analysis from two randomized controlled studies. Arthritis Rheum. 2005;52:3030-3038.
22.
Ebbing M., Bønaa KH, Nygård O., et al. Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA. 2009;302:2119-2126.
23.
Cole BF, Baron JA, Sandler RS, et al. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA. 2007; 97:2351-2359.
24.
Nzila A., Ward SA, Marsh K., Sims PF, Hyde JEComparative folate metabolism in humans and malaria parasites (part II): activities as yet untargeted or specific to Plasmodium. Trends Parasitol . 2005; 21:334-339.
25.
McGuire JJAnticancer antifolates: current status and future directions. Curr Pharm Des. 2003;9:2593-2613.
26.
Salim A., Tan E., Ilchyshyn A., Berth-Jones J.Folic acid supplementation during treatment of psoriasis with methotrexate: a randomized, double-blind, placebo-controlled trial. Br J Dermatol. 2006;154:1169-1174.
27.
Carter JY, Lollpapit MP, Lema OE, Tome JL, Nagelkerke NJ, Watkins WMReduction of the efficacy of antifolate antimalarial therapy by folic acid supplementation. Am J Trop Med Hyg. 2005; 73:166-170.
28.
Zhao R., Goldman IDResistance to antifolates. Oncogene. 2003;22:7431-7457.
29.
Chattopadhyay S., Tamari R., Min SH, Zhao R., Tsai E., Goldman IDCommentary: a case for minimizing folate supplementation in clinical regimens with pemetrexed based on the marked sensitivity of the drug to folate availability. Oncologist. 2007 ;12: 808-815.
30.
Jänne PA, Mayer RJChemoprevention of colorectal cancer. N Engl J Med. 2000;342:1960-1968.
31.
Kim YIFolate and colorectal cancer: an evidence-based critical review. Mol Nutr Food Res. 2007;51:267-292.
32.
Mason JB, Dickstein A., Jacques PF, et al. A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev . 2007;16: 1325-1329.
33.
Stolzenberg-Solomon RZ, Chang SC, Leitzmann MFFolate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am J Clin Nutr. 2006;83:895-904.
34.
Oaks BM, Dodd KW, Meinhold CL, Jiao L., Church TR, Stolzenberg-Solomon RZFolate intake, post-folic acid grain fortification, and pancreatic cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial . Am J Clin Nutr. 2010;91:449-455.
35.
van der Heijden JW, Oerlemans R., Dijkmans BA, et al. Folate receptor beta as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients. Arthritis Rheum. 2009;60:12-21.
36.
Cakmak SK, Gül U., Kiliç C., Gönül M., Soylu S., Kiliç A.Homocysteine, vitamin B12 and folic acid levels in psoriasis patients. J Eur Acad Dermatol Venereol. 2009;23:300-303.
37.
Half of Americans use vitamins and dietary supplements every day; Western Europe is more skeptical. Nielson.com. http://en-us.nielsen.com/content/nielsen/en_us/insights/consumer_insight/issue_16/half_of_americans.html. Accessed November 8, 2010.
38.
Sixty percent of Americans take a multivitamin so why do all disease indices continue to rise? March 20, 2008. http://www.articlesbase.com/health-articles/sixty-percent-of-americans-take-a-multivitamin-so-why-do-all-disease-indices-continue-to-rise-365239.html . Accessed November 8, 2010.