Galactose or lactose groups were conjugated to cholesterol-bearing pullulan (CHP). The CHP derivatives obtained formed monodisperse nanoparticles upon self-aggregation in water. Nanoparticles of galactoside-conjugated CHP self-aggregates were specifically internalized by rat hepatocytes and HepG2 cells. Galactoside-bearing CHP-coated liposome or oil droplet of O/W-emulsion was also taken up by HepG2 cells. Tissue distribution of the nanoparticle CHP self-aggregates changed dramatically with chemical conjugation of the galactose moiety. Galactoside-bearing nanoparticles were specifically accumulated in the liver.
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