Abstract
Studies have demonstrated the chemotactic response of periodontal ligament cells to a wide range of matrix molecules and growth factors, suggesting a therapeutic role for the latter in tissue lesion restoration. Impaired human gingival and periodontal ligament fibroblasts from adult donors were stimulated in vitro with growth factors or grown on a biosynthetic tissue-guiding membrane in the presence of tetracycline (minocycline) to assess the effects of these molecules on cell proliferation and tolerance to the drug. The results suggest that techniques involving tissue-guiding membranes and growth factors associated with inhibitors of collagenases constitute a promising biological-like way of restoring the delicate equilibrium disrupted by periodontal disease.
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