Gelatin microspheres containing the model protein, FITC-BSA, were prepared using the polymer dispersion technique. These microspheres were characterized for their thermal stability using differential scanning calorimetry. In order to prolong the release of the entrapped FITC-BSA, the microspheres were coated with a synthetic and biodegradable polymer, polycaprolactone. The polymer coated microspheres were characterised using infrared spectroscopy and scanning electron microscopy. In vitro release studies indicated that the release rate of FITC-BSA decreased with the increase in the coating concentration of the polymer.
Get full access to this article
View all access options for this article.
References
1.
1. Hora, M. S., R. K. Rana, J. H. Numberg, T. R. Tice, R. M. Gilley and M. E. Hudson. 1990. Pharm. Res., 7:1190.
2.
2. Norman, M. E., P. Williams and L. Illum. 1992. Biomaterials, 13:841.
3.
3. Esparaza, I. and T. Kissel. 1992. Vaccine, 10:714.
4.
4. Tabata, Y. and Y. Ikada. 1989. Pharm. Res., 6:422.
5.
5. Woodley, J. F.1994. Crit. Rev. There Drug Carrier Syst., 11:61.
6.
6. Lu Weig, I. and T. Park. 1995. J. Pharm. Sci. Technol., 49:13.
7.
7. Schroder, V. and A. Stahl. 1984. J. Immunol Methods, 70:129.
8.
8. Martin, M. E. D., J. B. Dewar and J. F. E. Newmann. 1988. Vaccine, 6:33.
9.
9. Jeyanthi, R. and K. P. Rao. 1989. Int. J. Pharm., 55:31.
10.
10. Rao, J. K., D. V. Ramesh and K. P. Rao. 1994. J. Biomater and Polym. Sci. Edn., 6:391.
11.
11. Schindler, A., R. Jeffcoat, G. L. Kimmel, C. G. Pitt, M. E. Wall and R. Zweidinger. 1977. Contempt. Top. Polym. Sci., 2:251.
