Partition of Poly(Oxyethylene)s with 5-Chloro-8-Quinolinoxyl End-Groups between 1-Octanol and Water

Abstract

Apparent partition coefficients for a series of poly(oxyethylene)s with 5-chloro-8-quinolinoxyl end-groups and different polyether chain lengths; POE^* ₄₀₀, POE^* ₁₀₀₀, POE^* ₁₀₀₀ and POE^* ₃₀₀₀ (the subscripts show the molecular weight of the polyether chain) were determined for the system 1-octanol/water at different pHs at 37°. The partition coefficient was found to decrease with increasing polyether chain length. The substituent constants were calculated and the effect of the substituents on the partition behavior of the compounds was estimated. The antibacterial effect of POE^* on gram-positive and gram-negative bacteria was found to be lower than that of CHQ. The activity of POE^* slightly increased in the presence of Fe³⁺ ions.