Abstract
Four polyanion-Pt(II)-complexes, PEE-cis-DACH-Pt, PEE-cis- (ACP)2-Pt, PCR-cis -DACH-Pt, and PCR-cis-(ACP)2-Pt, were synthesized by the reactions of polyanions such as poly[(2-ethoxytetrahydropyran-5,6-diyl)(1,2- dicarboxyethylene)](PEE) and poly[(3,4-dicarboxytetrahydropyran-2,6-diyl)- (1,2-dicarboxypropylene)](PCP) with cis-[Pt(amine)2)2](NO3) 2, where the amine was 1,2-diaminocyclohexane (DACH) or aminocyclopropane (ACP). The biologi cal activities of the complexes were measured in vitro against A-459 nonsmall cell lung, Sk-OV-3 ovarian, SK-Mel-2 melanoma, XF-498 CNS, and HCT-15 colon tumor cell lines. The increased life span was measured against L1210 leukemia and found to be 223% for PCP-cis-(ACP)2-Pt(II) at the dose of 25 mg/Kg.
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