A new approach to the targeted thermally activated transport of chemical agents and physiologically active compounds is reported. The method involves the immobilization of these compounds on a water-soluble polymer with a low critical solution temperature and heating the delivery site above the critical temperature. The approach was illustrated with trypsin immobilized on N-isopropylacrylamide-acrylamide-N-acryloylphthalimide ternary copoly mers.
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