The antimicrobial drug metronidazole was attached to dextran. Two methods of dextran-metronidazole synthesis were studied: (1) the reaction of metronidazole with chloroacetylated derivatives of crosslinked dextran microparticles in basic aprotic solvents, and (2) the reaction of metronidazole chloroacetic acid ester with crosslinked dextran microparticles in basic media. The release of metronidazole from the two types of macromolecular prodrugs was compared.
Get full access to this article
View all access options for this article.
References
1.
Sa'sa, S.I., H.S. Khalil and I.M. Jalal.1988. Microchem. J., 37(2):190-199, CA 108,210.112.
2.
Johansen, M. and C. Larsen.1985. Int. J. Pharm., 3:227-241.
3.
Larsen, C. and P. Kurtzhals.1988. Int. J. Pharm., 41(1-2):121-129.
4.
Epstein, N.A. and L.F. Mikhaleva.1988. Khim. Farm. Zh. , 22(10): 1269-1272.
5.
Vermeersch, H., J.P. Remon, D. Permentier and E. Schacht.1990. Int. J. of Pharmaceuticals , 60:253-260.
6.
Vermeersch, J., F. Vandome, D. Permentier and E. Schacht.1985. Bull. Soc. Chim. Belg., 94:591-596.
7.
Schacht, E., J. Vermeersch, F. Vandome, R. Vercanteren and J. Remon.J. of Controlled Rel., 2:245-256.
8.
Larsen, C.1986. Acta Pharm. Sci., 23:279-288.
9.
Larsen, C. and M. Johansen.1986. Arch. Pharm., 14(2):44-51.
10.
Larsen, C., P. Kurtzhals and M. Johansen.1987. Arch. Pharm. Chem. Sci. Ed., 15:100-109.
11.
Larsen, C. and M. Johansen.1989. J. Chromatogr., 389(1):227-235.
12.
Larsen, C. and P. Kurtzahls.1988. Acta Pharm. Sued., 25(1):1-14.
13.
Macoveanu, M. , Al. Tofan, P. Gorincioi, A. Carpov, G.C. Mocanu and D. Mihai.1991. "Process of Preparation of Stabilization Agent for Organic Medium;' Rom. Pat. 102.878.
14.
Mocanu, G. and A. Carpov.1992. Cell. Chem. and Technol., 6:675-684.
15.
1985. US Pharmacopea XXI, Revision. US Pharmacopeal Convention, Rockville, MD, p. 1420.
16.
Helferich, F.1962. Ion ExchangeNew York: McGraw-Hill Book Comp., p. 72.
17.
Saburov, M.A. and K.M. Saldadze.1966. J. Prikl. Khem. , 39(1):106-111.
