Poly(Glyceryl Methacrylate) Hydrogels - Effect of Composition and Crosslinking Density on Structure and Release of Dextran as a Model Macromolecule

Abstract

A series of hydrogels based on glyceryl methacrylate (pGMA) were prepared with different ratios of ethylene glycol dimethacrylate (EGDMA) and ethyl methacrylate (EMA) in order to vary the degree of crosslinking and the degree of hydrophobicity of the matrices, respectively. The swelling be haviour and the crosslinking density of the hydrogels were characterized and the structure was determined by scanning electron microscopy and porosime try. FITC-dextran (molecular weight 20,000) was imbibed into the gels and the release rate studied. It was found that the initial rate of release and the total amount of dextran release varied as an inverse function of crosslinking and monomer concentration, but as a linear function of EMA concentration.

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References

Graham, N.B. and M.E. McNeil. 1984. Biomaterials , 5:27.

Ratner, B.D. and A.S. Hofmann. 1976. "Synthetic Hydrogels for Biomedical Application," in Hydrogels for Medical and Related Applications , J. D. Andrade , ed., American Chemical Society, Washington, DC, pp. 1-35.

Drobnik, J. , P. Spacek and O. Wichterle. 1974. J. Biomed. Mater. Res., 8:45.

Anderson, J.M. , T. Koinis , T. Nelson , M. Horst and D.S. Love. 1976. In Hydrogels for Medical and Related Applications, J. D. Andrade , ed., American Chemical Society, Washington, DC, p. 167.

Cowsar, D.R. , O.R. Tarwater and A.C. Tanquary. 1976. "Controlled Release of Fluoride from Hydrogels for Dental Applications," in Hydrogels for Medical and Related Applications, J. D. Andrade , ed., American Chemical Society, Washington, DC, p. 180.

Schacht, E.H. 1984. "Hydrogel Drug Delivery Systems , Physical and Ionogenic Drug Carriers," in Recent Advances in Drug Delivery Systems," J. M. Anderson and S. W. Kim, eds., New York: Plenum Press, p. 259.

Kost, J. and R. Langer. 1987. "Equilibrium Swollen Hydrogels in Controlled Release Applications," in Hydrogels in Medicine and Pharmacy , N. A. Peppas , ed., Florida: CRC Press, p. 95.

Refojo, M.F. 1965. J. Appl. Pblymer Sci., 9:3461.

Woerly, S. , C. Lavallee and R. Marchand. 1990. Biomaterials, 11:97.

10.

Dusek, K. and W. Prins. 1969. Adv. Polymer Sci., 6:1.

11.

Refojo, M.F. 1965. J. Appl. Polymer Sci., 9:3417.

12.

Higgins, J.S. , J.V. Dawkins , G.G. Maghami and S.A. Shakir. 1986. Polymer, 27:931.

13.

Reinhart, C.T. , R.W. Korsmeyer and N.A. Peppas. 1981. Int. J. Pharm. Tech. & Prod. Mfr., 2:9.

14.

Winsiewski S. and S.W. Kim. 1980. J. Membr. Sci. , 6:299.

15.

Baker, R.W. and H.K. Lonsdale. 1974. In Controlled Release of Biologically Active Agents, A. C. Tanquary and R. E. Lacey , eds., New York: Plenum Press, p. 15.