Abstract
The dissolution kinetics, in an aqueous medium, of a water solu ble drug dispersed in an insoluble polymeric matrix, depends highly on the drug loading. A computer model of cisplatin loaded poly(lactide-co-glycolide) microspheres dissolution confirms the hypothesis that only the drug crystals connected to the surface of the microspheres are capable of dissolving through a site percolation mechanism. This behavior may also be possible with other drug release systems, limiting their use for controlled release.
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