Nucleic acid analogs were prepared by grafting nucleic acid base derivatives containing hydroxy groups onto poly(L-lysine). The polymers con tained about 70 unit% of the nucleic acid bases, and were easily soluble in water at neutral pH value. Conformational changes and polymer complexes with polynucleotides [Poly(A) and Poly(C)] were observed with specific base- base interactions in aqueous solution.
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References
1.
Gudibande, S.R. , S. Jayasena and M.J. Behe.1988. Biopolymers , 27:1905.
2.
Sarkar, P.K. and J.T. Yang.1965. Biochemistry , 4:1238.
3.
Thiele, D. and W. Guschlbauer.1971. Biopolymers, 10:143.
4.
Thiele, D., W. Guschlbauer and A. Favre.1972. Biocheim. Biophys. Acta, 272:22.
5.
Baba, Y., K. Fujiloka and A. Kagemoto.1978. Polym. J., 10:241.
6.
Inaki, Y. and K. Takemoto.1987. Current Topics in Polymer Science , Volume I, R. M. Ottenbrite , L. A. Utracki and S. Inoue, eds., Hanser Publisher , p. 79.
7.
Pitha, J.1983. Adv. Polym. Sci., 50:1.
8.
Takemoto, K. and Y. Inaki.1981. Adv. Poly. Sci., 41:1.
9.
Overberger, C.G. and Y. Morishima.1980. J. Polym. Sci. Polym. Chem. Ed., 18:1247-1267.
10.
Ludwick, A.G. and C.G. Overberger.1980. J. Polym. Sci. Polym. Chem. Ed., 18:2123, 2139.
11.
Brandt, K.A. and C.G. Overberger.1985. J. Polym. Sci. Polym. Chem. Ed., 23:1981.
12.
Overberger, C.G. and S. Kikyotani.1983. J. Polym. Sci. Polym. Chem. Ed., 21:525, 541.
13.
Overberger, C.G. and C.X. Lu .1985. J. Polym. Sci. Polym. Chem. Ed., 23:1321.
14.
Overberger, C.G. and C.C. Chen.1986. J. Polym. Sci. Polym. Chem. Ed., 24:167.
15.
Brahme, N.M. and W.T. Smith, Jr. 1984. J. Polym. Sci. Polym. Chem. Ed., 22:813.
16.
Smith, Jr., W.T. and N.M. Brahme.1985. J. Polym. Sci. Polym. Chem. Ed., 23:879.
17.
Ludwick, A.G. , K.S. Robinson and J. McCloud, Jr.1986. J. Polym. Sci. Polym. Symp., 74:55.
18.
Wada, T., Y. Inaki and K. Takemoto.1989. Polym. J., 21:11
19.
Wada, T., Y. Inaki and K. Takemoto.1988. Polym. J. , 20:1059.
20.
Wada, T., Y. Inaki and K. Takemoto.1989. J. Bioactive and Compatible Polymer , 4:25.
21.
Wada, T., Y. Inaki and K. Takemoto.Polym. J, in contribution.
22.
Seeney, C.E. and H.J. Harwood.1975. J. Macromol. Sci.-Chem. , A9:779.
23.
Ishikawa, T. , Y. Inaki and K. Takemoto.1978. Polym. Bull., 1:85.
24.
Thomas, Jr., G.J. and Y. Kyogoku.1967. J. Am. Chem. Soc. , 89:4170.
25.
Fang, S., Inaki Y. and K. Takemoto.1984. J. Polym. Sci. Polym. Chem. Ed., 22:2455.
26.
Thiele, D., W. Guschlbauer and A. Faver.1972. Biochim. Biophys. Acta, 272:22.
27.
Fujioka, K. , Y. Baba, A. Kagemoto and R. Fujishiro.1980. Polym. J., 12:843.
