Dextran was modified using three different methods: a) partial periodate oxidation and subsequent reduction of the aldehyde groups, b) suc cinoylation and c) chloroformate activation with subsequent reaction with 2- hydroxypropylamine, ethylenediamine and tris(2-aminoethyl)amine. Degrada tion of these dextran derivatives by dextranases was investigated. It was observed that the rate of degradation decreased with increasing degree of chemical modification of the parent polysaccharide. The nature of modification had no significant influence on the rate of degradation.
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References
1.
Molteni, L. in Drug Carriers in Biology and Medicine. G. Gregoriadis, ed. London:Academic Press, p. 107 ( 1979).
2.
Larsen, C. and M. Johansen.Arch. Pharm. Chem., 92:809 (1985).
3.
Larsen, C.Adv. Drug Delivery Rev., 3:103 (1989).
4.
Yalpani, M.CRC C.R. Biotechn., 3(4):375 (1986).
5.
Schacht, E. in Polymers in Controlled Drug Delivery. L. Illum and S. S. Davis, eds. Bristol:IOP Publishing Limited, p. 131 (1987).
6.
Tsuchuya, H.M. , A. Jeanes, H.M. Bricker and C.A. Wilhm.J. Bacteriol. , 64:513 (1952).
7.
Jeanes, A., C.A. Wilham, R.W. Jones, H.M. Tsuchuya and C.E. Rist.J. Am. Chem. Soc., 75:5911 (1953).
8.
Bourne, E.J. , D.H. Hutson and H. Weigel.Biochem. J., 85:158 (1962).
9.
Hutson, D.H. and H. Weigel.Biochem. J., 88:588 (1963).
10.
Wheatley, M.A. and M. Moo-Young.Biotechnol. Bioeng., 19:219 (1977).
11.
Blackader, D.A. and C. Hinshelwood.J. Chem. Soc., 2720 (1958).
12.
Roth, M.Anal. Chem., 43(7):880 (1971).
13.
Lindroth, P. and K. Mopper.Anal. Chem., 51(11):1667 (1979).
14.
Ishak, M.F. and T.J. Painter.Carbohydr. Res., 64:189 (1978).
15.
Ruys, L. Ph.D. Thesis, State University of Ghent, Ghent (1984).
16.
Vasil'ev, A. E., G.N. Kol'tsova, N.K. Krylova, A.M. Ovsepyan, V.M. Shlimak, G. Rozenberg.Ya. Zh. Obshch. Khim., 47(7):1641 (1977).
17.
Vandoorne, F., R. Vercauteren, D. Permentier and E. Schacht.Makromol. Chem. , 186:2455 (1985 ).
18.
Schacht, E. , J. Vermeersch, F. Vandoorne, R. Vercauteren and J.P. Remon.J. Controll. Release. , 2:245 (1985).
19.
Vermeersch, J. and E. Schacht.Makromol. Chem., 187:125 (1986).
20.
Vandoorne, F. , D. Bruneel, R. Vercauteren and E. Schacht. (Article submitted for publication.)
21.
Ludwig, H. and K.O. Greulich.J. Chem. Res., S:30 (1979).
22.
Ludwig, H. and K.O. Greulich.Biophys. Chem., 8:163 (1978).
23.
Aspinal, G.O.The Polysaccharides, 3. London:Academic Press, p. 37 (1985).
24.
Rosemeyer, H. and F. Seela.Makromol. Chem., 185:687 (1984).
25.
Kobayashi, K., H. Sumitomo and H. Ichikawa.Macromolecules , 19:529 (1986).
26.
Chaves, M.S. and F. Arranz.Makromol. Chem., 186:17 (1985).
27.
Fukumoto, J. , H. Tsuji and D. Tsuru.J Biochem., pp. 69, 1113 (1971).
28.
Suga, K., G. Van Dedemand and M. Moo-Young.Biotechnol. Bioeng., 17:185 (1975).
29.
Webb, E. and I. Spencer-Martins .Can. J. Microbiol., 29(9):1092 (1983).