Synthesis and Characterization of Polyanionic Materials for Testing of Antitumor Activity. I-The 1:2 Cyclocopolymer of Citraconic Anhydride and Divinyl Ether
Restricted accessResearch articleFirst published online July, 1987
Synthesis and Characterization of Polyanionic Materials for Testing of Antitumor Activity. I-The 1:2 Cyclocopolymer of Citraconic Anhydride and Divinyl Ether
The cyclopolymer of citraconic anhydride and divinyl ether was resynthesized for the purpose of optimizing its antitumor activity with respect to molecular weight and molecular weight distribution. Thus, the cyclocopolymer was syn thesized under a variety of conditions which included use of chain-transfer agents, and the samples were fractionated. Evaluation of the various fractions against P-388 lymphocytic leukemia cells showed that the effectiveness of the material is highly dependent on both molecular weight and molecular weight distribution. An optimum sample resulted in an increase in survival times of treated vs. control animals of 267%.
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