Restricted accessResearch articleFirst published online 2015-11
Physicochemical,molecular,and biological properties of complexes formed between aminoglycoside antibiotics and some anionic copolymers of acrylic series: Part II
Physicochemical and molecular properties of complexes formed by aminoglycoside antibiotics, including neomycin, gentamicin, kanamycin, and amikacin, in the form of bases and carboxyl- or sulfo-comprising copolymers of acrylamide or N-(2-hydroxypropyl)methacrylamide have been studied. The toxicity of complexes in vitro and their antimicrobial activity are matched to their behavior in solutions. Direct dependency of toxic and antibacterial properties of polymer complexes of aminoglycoside antibiotics on their molecular characteristics and stability opens up perspectives of targeting control over their antimicrobial activity by changing the microstructure of their polymer carrier chains.
MashkovskijMD. Drugs. 16th ed.Moscow: Novaya Volna, 2012, 1216 pp. (in Russian).
2.
LobusevaANPozdniakovaVPFirsovAA. Modern aminoglycosides in the treatment of septic diseases. Antibiot Med Biotek1985; 30: 55–61 (in Russian).
3.
HaddadNSRavisWRPedersoliWM. Pharmacokinetics and tissue residues of gentamicin in lactating cows after multiple intramuscular doses are administered. Am J Vet Res1987; 48: 21–27.
4.
ReddyTTKanoAMaruyamaA. Thermosensitive transparent semi-interpenetrating polymer networks for wound dressing and cell adhesion control. Biomacromolecules2008; 9: 1313–1321.
5.
ShtilmanMI. Polymers for medical and biological purposes. Мoscow: Academkniga, 2006, 399 pp. (in Russian).
6.
LiYSuXYeQ. A polyacrylic acid as a carrier for immobilization of penicillin acylase. J Appl Polym Sci2002; 86: 2067–2069.
7.
NurkeevaZSKhutoryanskiyVVMunGA. Polycomplexes of poly(acrylic acid) with streptomycin sulfate and their antibacterial activity. Eur J Pharm Biopharm2004; 57: 245–249.
8.
ZhouYHuangWLiuJ. Self-assembly of hyperbranched polymers and its biomedical applications. Adv Mater2010; 22: 4567–4590.
9.
MahkamM. Controlled release of biomolecules from pH-sensitive hydrogels prepared by radiation polymerization. J Bioact Compat Polym2004; 19: 209–220.
10.
DuncanR. The dawning era of polymer therapeutics. Nat Rev Drug Discov2003; 2: 347–360.
11.
ThatteSDatarKOttenbriteRM. Perspectives on: polymeric drugs and drug delivery systems. J Bioact Compat Polym2005; 20: 585–601.
12.
ShtilmanMI. Immobilization on polymers. Utrecht; Tokyo: VSP, 1993, 496 pp.
13.
KopečekJKopečkováP. HPMA copolymers: origins, early developments, present and future. Adv Drug Deliv Rev2010; 62: 122–149.
14.
SolovskiiMVTarabukinaEBAmirovaAI. Complexation of anionic copolymers of acrylamide and N-(2-hydroxypropyl)methacrylamide with aminoglycoside antibiotics. Russ J Phys Chem A2014; 88: 428–432.
15.
SolovskiiMVGavrilovaIISmirnovaMY. Synthesis of low molecular weight water soluble anionic copolymers of acrylamide. Chem Chem Technol (Izvestija VUZov Series) 2008; 51: 72–74 (in Russian).
16.
TarabukinaEBAmirovaAIShultsevaEL. Effect of synthesis conditions on molecular characteristics of acrylamide copolymers with acrylic acid, carriers of cationic biologically active substance. Russ J Appl Chem2009; 82: 1606–1614.
17.
SolovskiiMVSmirnovaMYAmirovaAI. Synthesis of low-molecular-weight N-(2-hydroxypropyl)methacrylamide sulfonated co-polymers as carriers of biologically active substances. Russ J Appl Chem2012; 85: 426–431.
18.
AnufrievaEVKirpachABKrakovyakMG. A coil-to-globule transition in macromolecules with anthracene-containing units. Polym Sci A2001; 43: 1127–1133.
19.
SnyderSLSobocinskiPZ. An improved 2,4,6-trinitrobenzenesulfonic acid method for the determination of amines. Anal Biochem1975; 64: 284–288.
20.
AnufrievaEVGotlibYY. Investigation of polymers in solution by polarized luminescence. Adv Polym Sci1981; 40: 1–68.
21.
MorawetzH. Macromolecules in solution. New York: John Wiley & Sons, 1966, 398 pp.
22.
KratochvilP. Classical light scattering from polymer solution. Amsterdam: Elsevier, 1987, 334 pp.
23.
SchärtlW. Light scattering from polymer solutions and nanoparticle dispersions. Berlin: Springer, 2007, 191 pp.
24.
TsvetkovVN. Rigid-chain polymers, hydrodynamic and optical properties in solution. New York: Plenum Press, 1989, 490 pp.
SvedbergTPedersenKO. The ultracentrifuge. London; Oxford: Clarendon Press, 1940, 406 pp.
27.
YeropkinMYSolovskiiMVYeropkinaYM. Comparative study of the cytotoxic action of antibiotics polymeric derivatives—aminoglycosides. Toxikol Vestn2006; 5: 18–22 (in Russian).
28.
SolovskiiMVDenisovVMRyadinskayaNY. Synthesis of copolymers of N-(2-hydroxypropyl)methacrylamide with acrylic acid and gentamicin salts of these copolymers. Russ J Appl Chem1999; 72: 1443–1449.
29.
SchachmanH. Ultracentrifugation in biochemistry. New York: Academic Press, 1959, 75 pp.
