In this study, polyethylene (PE) was fabricated with porosity greater than 60% and 140—830 µm pore sizes which is suitable for fibrovascularization. The process involved three-dimensional printing of PE particles with water soluble adhesive powders followed by two-stepped heat treatment at 145°C with binder leaching between steps. Spherical ocular implants were fabricated by this process that had pore size, shaping and suturing ability comparable to commercially available porous PE (Medpor®), but had lower density, higher porosity, and antibiotic uptake, as well as, more uniform pore interconnectivity and lower needle exertion force for suturing.
Moshfeghi DM, Moshfeghi AA and Finger PTEnucleation. Surv Ophthalmol2000; 44(4): 277-301.
2.
Chalasani R., Poole-Warren L., Conway RM and Ben-Nissan B.Porous orbital implants in enucleation: a systematic review. Surv Ophthalmol2007; 52(2): 145-155.
3.
Sami D., Young S. and Petersen R.Perspective on orbital enucleation implants. Surv Ophthalmol2007; 52(3): 244-265.
4.
Kurtz SM, Muratoglu OK, Evans M. and Edidin AAAdvances in the processing, sterilization, and crosslinking of ultra-high molecular weight polyethylene for total joint arthroplasty. Biomaterials1999; 20: 1659-1688.
5.
Sobieraj MC and Rimnac CMUltra high molecular weight polyethylene: mechanics, morphology, and clinical behavior. J Mech Behav Biomed Mater2009; 2: 433-443.
6.
El-Rehima HAA.Hemodialysis Membranes based on functionalized high-density polyethylene. J Bioact Compat Polym2005; 20(1): 51-75.
7.
Park HK, Dujovny M., Diaz FG and Guthikonda M.Biomechanical properties of high density polyethylene for pterional prosthesis . Neuro Res2002; 24: 671-676.
8.
Liu JK, Gottfried ON, Cole CD, Dougherty WR and Couldwell WTPorous polyethylene implant for cranioplasty and skull base reconstruction . Neurosurg Focus2004; 16(3): 1-5.
9.
Patel PJ, Rees HC and Olver JMFibrovascularization of porous polyethylene orbital floor implants in humans . Arch Ophthalmol2003; 121: 400-403.
10.
Park WC, Han SK, Kim NJ, Chung TY and Khwarg SIEffect of basic fibroblast growth factor on fibrovascular ingrowth into porous polyethylene anophthalmic socket implants. Korean J Ophthalmol2005; 19(1): 1-8.
11.
Park SW, Seol HY, Hong SJ, Kim KA, Choi JC and Cha IHMagnetic resonance evaluation of fibrovascular ingrowth into porous polyethylene orbital implant. J Clinic Imag2003; 27(6): 377-381.
12.
Lam CXF , Mo XM, Teoh SH and Hutmacher DWScaffold development using 3D printing with a starch-based polymer. Mater Sci Eng C2002 ; 20: 49-56.
13.
Leong KF, Cheah CM and Chua CKSolid freeform fabrication of three-dimensional scaffolds for engineering replacement tissues and organs. Biomaterials2003; 24: 2363-2378.
14.
Suwanprateeb J.Improvement in mechanical properties of three dimensional printing parts made from natural polymers reinforced by acrylate resin for biomedical applications: a double infiltration approach. Polym Inter2006; 55: 57-62.
15.
Chumnanklang R., Panyathammaporn T., Sitthiseripratip K. and Suwanprateeb J.3D-printing of hydroxyapatite scaffold: effect of binder concentration in pre-coated particle on part strength. Mater Sci Eng C2007; 27: 914-921.
16.
Suwanprateeb J., Sanngam R. and Suwanpreuk W.Fabrication of bioactive hydroxyapatite/bis-GMA based composite via three dimensional printing. J Mater Sci: Mater in Med2008; 19: 2637-2645.
17.
Simon JL, Roy TD, Parsons JR, Rekow ED, Thompson VP, Kemnitzer J., et al. Engineered cellular response to scaffold architecture in a rabbit trephine defect. J Biomed Mater Res2003; 66A: 275-282.
18.
Roy TD, Simon JL, Ricci JL, Rekow ED, Thompson VP and Parsons JRPerformance of degradable composite bone repair products made via three-dimensional fabrication techniques. J Biomed Mater Res2003; 67A: 1228-1237.
19.
Suwanprateeb J., Sanngam R., Suvannapruk W. and Panyathanmaporn T.Mechanical and in vitro performance of apatite-wollastonite glass ceramic reinforced hydroxyapatite composite fabricated by 3D-printing. J Mater Sci: Mater in Med2009; 20: 1281-1289.
20.
Cui T. , Wang X., Yan y and Zhang R.Rapid prototyping a double-layer polyurethane-collagen conduit and its schwann cell compatibility. J Bioact Compat Polym2009; 24: 5-17.
21.
Will J., Melcher R., Treul C., Travitzky N., Kneser U., Polykandriotis E., et al. Porous ceramic bone scaffolds for vascularized bone tissue regeneration . J Mater Sci: Mater in Med2008; 19(8): 2781-2790.
22.
Suwanprateeb J. and Chumnanklang J. Threedimensional printing of porous polyethylene structure using water-based binder. J Biomed Mater Res: Part B Appl Biomater2006; 78(1): 138-145.
23.
Suwanprateeb J., Wasoontararat K. and Suvannapruk W.Fabrication of porous polyethylene by two-stepped heat treatment and powder printing. Adv Mater Res2010; 93-94: 165-168.
24.
Li SX, Zhao J., Lu P. and Xie Y.Maximum packing densities of basic 3D objects. Chinese Sci Bull2010; 55: 114-119.
25.
Aste T., Saadatfar M. and Sendena TJGeometrical structure of disordered sphere packings. Phys Rev E2005; 71: 061302/1-5.
26.
Kundu B., Sinha MK, Mitra MK and Basu D.Fabrication and characterization of porous hydroxyapatite ocular implant followed by an in vivo study in dogs. Bull Mater Sci2004; 27(2): 133-140.
27.
Wha-Sun Chung, Su-JungSong, Sang-Hyeok Lee and Eun-Ah Kim.Fibrovascularization of intraorbital hydroxyapatite-coated alumina sphere in rabbits. Korean J Ophthalmol2005; 19: 9-17.
28.
Rivera-Munoz E., Diaz JR, Rodriguez R., Brostow W. and Castaro VMHydroxyapatite spheres with controlled porosity for eye ball prosthesis: processing and characterization . J Mater Sci: Mater in Med2001; 12(4): 305-311.
29.
Bigham WJ, Stanley P., Cahill Jr JM, Curran RW and Perry ACFibrovascular ingrowth in porous ocular implants: the effect of material composition, porosity, growth factors, and coatings. Ophthal Plast Reconstr Surg1999; 15(5): 317-325.
30.
Rubin PA, Popham JK, Bilyk JR and Shore JWComparison of fibrovascular ingrowth into hydroxyapatite and porous polyethylene orbital implants. Ophthal Plast Reconstr Surg1994; 10: 96-103.
31.
Rubin PA, Bilyk JR and Shore JWOrbital reconstruction using porous polyethylene sheets. Ophthalmology1994; 101: 1697-1708.
32.
Seong YS, Lee SY and Kim SJMorphological study of a new orbital implant: hydroxyapatite-coated porous alumina in rabbit. J Korean Ophthalmol Soc2001; 42: 1354-1361.
33.
Murphy CM, Haugh MG and O’Brien FJThe effect of mean pore size on cell attachment, proliferation and migration in collagenglycosaminoglycan scaffolds for bone tissue engineering . Biomaterials2010; 31(3): 461-466.
34.
Karageorgiou V. and Kaplan D.Porosity of 3D biomaterial scaffolds and osteogenesis . Biomaterials2005; 26(27): 5474-5491.
35.
Kuboki Y., Jin Q. and Takita H.Geometry of carriers controlling phenotypic expression in BMP-Induced osteogenesis and chondrogenesis. J Bone Joint Surg Am2001 ; 83: S105-S115.
36.
Liao S., Wang W., Yokoyama A., Zhu Y., Watari F., Ramakrishna S., et al. In vitro and in vivo behaviors of the three-layered nanocarbonated hydroxyapatite/collagen/PLGA composite. J Bioact Compat Polym2010; 25: 154-168.
37.
Chen G., Zhou P., Mei N., Chen Z., Shao Z., Pan L., et al. Silk fibroin modified porous poly (α-caprolactone) scaffold for human fibroblast culture in vitro. J Mater Sci: Mater in Med2004; 15: 671-677.
38.
Lu Q., Hu K., Feng QL and Cui F.Growth of fibroblast and vascular smooth muscle cells in fibroin/collagen scaffold. Mater Sci and Eng C2009; 29: 2239-2245.
39.
Chen YM, Xi T., Zheng Y., Guo T., Hou J., Wan Y., et al. In vitro cytotoxicity of bacterial cellulose scaffolds used for tissue-engineered bone. J Bioact Compat Polym2009; 24(1): 137-145.
40.
Kwon JH, Kim SS, Kim BS, Sung WJ, Lee SH, Lim JI, et al. Histological behaviour of HDPE scaffolds fabricated by the ‘‘press-and-baking’’ method. J Bioact Compat Polym2009; 20: 361-376.
41.
Phani KK, Niyoki SK, Maitra AK and Raychaudhury M.Strength and elastic modulus of a porous brittle solid: an acousto-ultrasonic study. J Mater Sci1986; 21(12): 4335-4341.
42.
Boccaccini AR and Fan Z.A new approach for the Young’s modulus-porosity correlation of ceramic materials. Ceram Inter1997; 23: 239-245.
43.
Kwan YBP , Stephenson DJ and Alcock JRThe porosity dependence of flexural modulus and strength for capsule-free hot isostatically pressed porous alumina. J Mater Sci2000 ; 35(5): 1205-1211.
44.
Aly MSEffect of pore size on the tensile behavior of open-cell Ti foams: experimental results. Mater Lett2010; 64(8): 935-937.
