Abstract
The effect of platelet-rich plasma (PRP) on a porous scaffold of nano-hydroxyapatite/collagen/poly(lactic-acid) (nHAC/PLA) to repair a mandible defect in a rabbit model was evaluated. A 10 × 8 mm2 perforated defect roughly 5 mm thick was made in the right mandible of each animal, preserving the periosteum in situ. The defects were treated using nHAC/PLA grafts with or without autologous PRP. The results of X-ray, dual energy X-ray measurements of bone mineral density, scanning electron microscopy, histology, and newly formed bony area evaluated by ANOVA showed that PRP significantly shorten recovery time and accelerate defect repair, especially in the first month. The incorporation of PRP appears to be an effective approach for improving bone repair.
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