Preparation and PH Responsive Behavior of Poly(Vinyl Alcohol)— Chitosan

Abstract

A full-interpenetrating polymer network (Full-IPN) hydrogel based on poly(vinyl alcohol)/chitosan/poly(acrylic acid) by the simultaneous-IPN method was synthesized and characterized by FT-IR and scanning electron microscopy. By varying the composition, different gels with different swelling dynamics, pH behavior and shrinking behavior of the gels were obtained. All the hydrogels swelled and reached equilibrium within five hours, indicating that the hydrogels have fast swelling properties and a relatively high swelling ratio (SR). Increasing the hydrophilic PAA in the full-IPN hydrogels increased the SR. The introduction of PVA and CTS to the full-IPN enhanced the hydrogel's biocompatibility. The poly(vinyl alcohol)/chitosan/poly(acrylic acid) full-IPN hydrogels exhibited a swelling change in response to pH of the swelling medium, and could be useful a potential modulation systems in biomedical fields.

Keywords

poly(vinyl alcohol)chitosan poly(acrylic acid)pH-sensitive hydrogels full-interpenetrating polymer network.

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Ju, H.K. , Kim, S.Y. , and Lee, Y.M. (2004). Polymer , 42: 6851—6857.

Bajpai, A.K. , Bajpai, J. , and Shukla, S. (2001). React. Funct. Polymers, 50: 9—21.

Tokita, M. and Tamaka, T. (1991). J. Chem. Phys., 95: 4613.

Maolin, Z. , Jun, L. , Min, Y. , and Hongfei, H. (2000). Radiat. Phys. Chem. 58: 397—400.

Park, T.G. and Hoffman, A.S. (1990). Immobilization and characterization of β-galactosidase in a thermally reversible hydrogel beads, J. Biomed. Mater. Res., 21: 24—32.

Qiu, Y. and Park, K. (2001). Environment-sensitive hydrogels for drug delivery , Adv. Drug Deliv. Rev., 53: 321—339.

Hoffman, A.S. (1997). Intelligent Polymer. Park, K. (ed.), Controlled Drug Delivery: Challenge And Strategies, pp. 485—497. American Chemical Society, Washington, DC.

Kaji Wara, K. and Rossmurphy, S.B. (1992) Nature , 355: 208.

Zhang, T. , Yan, Y. , Wang, X. , Xiong, Z. , Lin, F. , Wu, R. , and Zhang, R. (2007). J. Bioact. Comp. Polym., 22: 15—25.

10.

Peppas, N.A. (1978). Hydrogels in Medicine and Pharmacy, Properties and Applications, Vol. 3, CRC Press, Boca Raton, FL.

11.

Brannon-Peppas, L. and Peppas, N.A. (1990). Biomaterials , 11: 635—644.

12.

Khare, A.R. and Peppas, N.A. (1993). J. Biomater. Sci. Polymer Ed., 4: 275—289.

13.

Patel, V.R. and Amiji, M.M. (1996). Pharm. Res., 13: 588—593.

14.

Sawada, S.-I. , Nomura, Y. , Aoyama , Y. , and Akiyoshi, K. (2006). J. Bioact. Comp. Polymer , 21: 487—501.

15.

Dong, L.C. and Hoffman, A.S. (1991). J. Controlled Release, 15: 141—152.

16.

Irie, M. , Misumi, Y. , and Tanaka, T. (1993) Polymer, 34: 4531.

17.

Zhang, X.-Z. , Zhang, J.-T. , Zhuo, R.-X. , and Chu, C.-C. (2002). Polymer, 43: 4823—4827.

18.

Nishi, H. (1996). J. Chromotogr. A, 735: 57—76.

19.

Peters, E.C. , Lewandouski, K. , Petro , M. , Svec, F. , and Frechet, J.M.J. (1998). Anal. Commun., 3: 83—86.

20.

de Azevedo, W.M. , de Souza, J.M. , and de Melo, J.V. (1999). Syn. Met., 100: 241—248.

21.

Pandyopadhyay, P.K. and Shaw, M.T. (1982). J. Appl. Polymer Sci. , 27: 4323.

22.

Shchin, R. and Vilas, A. (2000). Eur. Polym. J., 36: 1379.

23.

Kim, S.J. , Lee, C.K. , Lee, Y.M. , Kim, I.Y. , and Kim, S.I. (2003). React. Funct. Polymers, 55: 291—298.

24.

Hirai, T. , Muruyama, H. , Suzuki, T. , and Hayashi, S. (1992). J. Appl. Polymer Sci., 45: 1849.

25.

Fang, Y. , Liu, S.X. , Hu, D.D. , Cui, Y.L. , and Xue, M. (1999)Polymer Bull., 43: 387—394.

26.

Wang, Y.P. , Yuan, K. , Li, Q.L. , and Gu, S.J. (2004). J. Func. Polymer, 17: 586—590.

27.

Vashuk, E.V. , Vorobieva, E.V. , Basalyga, I.I. , and Krutko, N.P. (2001). Mat. Res. Innovat. , 4: 350—352.

28.

Wu, X.S. , Hoffman, A.S. , and Yager, P. (1992). J. Polymer Sci. Polymer Chem . Ed. , 30: 2121—2129.

29.

Kim, S.J. , Par0k, S.J. , and Kim, S.I. (2003). React. Funct. Polymers, 55: 61—67.

30.

Wang, M. , Fang, Y. , and Hu, D. (2001). React. Funct. Polymers, 48: 215—221.

Preparation and PH Responsive Behavior of Poly(Vinyl Alcohol)— Chitosan—Poly(Acrylic acid) Full-IPN Hydrogels

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