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Abstract

Microencapsulation of theophylline in polyurethane was developed with 4, 4'-methylenediphenyl isocyanate (MDI), castor oil (CO) and ethylene diamine as a chain extender. Polyurethane microspheres were prepared in two steps pre-polymer preparation and microspheres formation. CO, MDI and theophylline were mixed first before suspending the mixture in an aqueous medium (stirred at 4, 000rpm) of the second reaction. Fourier transform infrared (FTIR) was employed to confirm polyurethane formation during the course of reactions. SEM illustrated microspheres with uniform spherical morphology. Particle size investigation with optical microscopy revealed size distribution of 27–128 m. Controlled release experiment of theophylline was performed in phosphate buffered saline (PBS) at pH 7.4 with ultraviolet (UV) spectrometer at 274nm. Drug release profiles showed initial release of 2–40% and further release for more than 10 days.

Keywords

polyurethane microspheres morphology theophylline isocynate

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References

Ansel, H.C. , Allen, J.L.V. and Popovich, N.G. (1999). Pharmaceutical Dosage Forms and Drug Delivery Systems, Lippincott Williams & Wilkins, Philadelphia .

Ranada, V.V. and Hollinger, M.A. (2004). Drug Delivery Systems, CRC Press, Inc., Boca Raton, London .

Mathiowitz, E. , Kreitz, M.R. and Brannon-Peppas, L. (1999). Microencapsulation: In the Encyclopedia of Controlled Drug Delivery, Vol. II, Mathiowitz, E., 493–546, John Wiley & Sons, New York .

Medline Plus [Internet] . Bethesda (MD) : Theophylline, U.S. National Library of Medicine and the Institute of Health (2003). April 1 – [cited 2005 May 5]. Available from: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a681006.html.

Ciardelli, G. , Cioni, B. , Cristallini, C. , Barbani, N. , Silvestri, D. and Giusti, P. (2004). Acrylic Polymeric Nanospheres for the Release and Recognition of Molecules of Clinical Interest . Biosens. Bioelectron, 20: 1083–1090 .

Katime, I. , Novoa, R. , Deapodaca, E.D. and Rodriguez, E. (2004). Release of Theophylline and Aminophylline from Acrylic Acid/n-alkyl Methacrylate Hydrogels . J. Polym. Sci. Part A: Polym. Chem., 42: 2756–2765 .

Ward, J.H. and Peppas, N.A. (2001). Preparation of Controlled Release Systems by Free-radical UV Polymerizations in the Presence of a Drug . J. Control. Release, 71: 183–192 .

Lelah, M.D. and Cooper, S.L. (1986). Polyurethanes in Medicine, CRC Press, Inc., Boca Raton, FL .

Davaran, S. and Entezami, A. (1997). Synthesis and Hydrolysis of Polyurethanes Containing Ibuprofen Pendant Groups . J. Bioact. Compat. Pol., 12: 47–58 .

10.

Grigorieva, M. , Gladir, I. and Galatenko, N. (2001). The Polyurethane-drug Composites: Synthesis, Properties and a Kinetic Model . J. Bioact. Compat. Pol., 16: 307–314 .

11.

Marconi, W. , Francolini, I. , Piozzi, A. and Dirosa, R. (2001). Antibiotic Releasing Urethane Polymers for Prevention of Catheter Related Infections . J. Bioact. Compat. Pol., 16: 393–407 .

12.

Shukla, P.G. , Kalidhass, B. , Shah, A. and Palaskar, D.V. (2002). Preparation and Characterization of Microcapsules of Water-soluble Pesticide Monocrotophos Using Polyurethane as Carrier Material . J. Microencapsul., 19: 293–304 .

13.

Subhaga, C.S. , Ravi, K.G. and Sunny, M.C. (1995). Evaluation of an Aliphatic Polyurethane as a Microsphere Matrix for Sustained Theophylline Delivery . J. Microencapsul., 12: 617–625 .

14.

Chaw, C.S. , Yang, Y.Y. , Lim, I.J. and Phan, T.T. (2003). Water-soluble Betamethasone-loaded Poly(lactic-co-glycolide) Hollow Microparticles as a Sustained Release Dosage Form , J. Microencapsul., 20: 349–359 .

15.

Prashantha, K. , Vasanth Kumar Pai, K. , Sherigara, B.S. and Prasannakumar, S. (2001). Interpenetrating Polymer Networks Based on Polyol Modified Castor Oil Polyurethane and Poly(2-hydroxyethylmethacrylate): Synthesis, Chemical, Mechanical and Thermal Properties . Bull. Mater. Sci., 24: 535–538 .

16.

Xiao, H. , Friesch, H. and Friesch, K. (1983). Interpenetrating Polymer Network from Polyurethane and Metacrylate Polymers. I. Effect of Molecular Weight of Polyol and NCO/OH Ratio of Urethane Prepolymer on Properties and Morphology of IPNs , J. Polym. Sci.: Polym. Chem., 21: 2547-2547 .

17.

Davaran, S. , Rashidi, M.R. , Hanaee, J. , Khani, J.A. , Mahkam, M. and Mahdi Hashemi, M. (2006). Synthesis and Degradation Characteristics of Polyurethanes Containing AZO Derivatives of 5-Amino Salicylic Acid , J. Bioact. Compat. Pol., 16: 315–325 .

Preparation and Characterization of Polyurethane Microspheres Containing Theophylline

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