Core/shell macrobeads, composed of a hydrogel core and a biodegradable polymeric shell, were designed and evaluated for the protection of islets from both fibrous tissue development as well as the modulation of the immune system rejection response. The core/shell macrobeads (2,000μm diameter) were prepared with approximately 150μm thick polymeric shells. Islets isolated from pancreas of C57/BL6 mice were encapsulated in these core/shell macrobeads. The islets-loaded core/shell macrobeads were planted in the peritoneal cavity of diabetes mellitus-induced C57/BL6 mice and the blood glucose concentrations were measured.
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