Sage Journals: Discover world-class research

Abstract

A soluble intralumenal stent for vascular anastomosis was prepared from glucose, dextran-40 and disodium (1–4)-2-deoxy-2-sulfoamino-ß-D-glucopyranuronan (S-chitosan). The in vitro and in vivo solubility of the stent was tested. Animal tests were carried out using femoral arteries of rabbits. In comparison with the previously reported data for poly(ethylene glycol), (PEG) and sugar stents, the S-chitosan containing stent (S-sugar stent) had a shorter dissolution time and a higher vessel patency rate that led to a higher rabbit survival rate. Neither irritation nor thrombosis, due to the introduction of S-sugar stent, was observed from histological sections 2 months after the anastomosis. This S-chitosan containing sugar stent is a promising candidate for fast sutureless anastomosis of vessels in non-trauma surgery.

Keywords

anastomosis sutureless dissolvable stent S-chitosan sugar

Get full access to this article

View all access options for this article.

References

1. Terada, S. , Sato, M. , Sevy, A. and Vacanti, JP. (2000). Tissue Engineering in the Twenty-First Century , Yonsei. Med. J., 41(6): 685–691 .

2. Ang, E.S. , Tan, K.C. , Tan, L.H. , Ng, R.T. and Song, I.C. (2001). 2-Octyl-cyanoacrylate-Assisted Microvascular Anastomosis: Comparison with a Conventional Suture Technique in Rat Femoral Arteries , J. Reconstr. Microsurg., 17(3): 193–201 .

3. Nakamura, T. , Fukui, A. , Maeda, M. , Kugai, M. , Inada, Y. , Teramoto, N. , Ishida, A. and Tamai, S. (2000). Microvascular Anastomoses Using an Nd-YAG Laser , J. Reconstr. Microsurg., 16(7): 577–584 .

4. Boeckx, W.D. , Darius, O. , van den hof, B. and van Holder, C. (1997). Scanning Electron Microscopic Analysis of the Stapled Microvascular Anastomosis in the Rabbit , Ann. Thorac. Surg., 63(6 Suppl): S128–134 .

5. Pikoulis, E. , Rhee, P. , Nishibe, T. , Leppäniemi, A.K. , Fishback, N. , Hufnagel, H.V. , Wherry, D.C. and Rich, N.M. (1998), Arterial Reconstruction with Vascular Clips is Safe and Quicker than Sutured Repair , Cardiovascular Surgery, 6(6): 573–578 .

6. Eton, D. (2000). Stent-Assisted Vascular Anastomoses , Semin. Vasc. Surg., 13(1): 87–92 .

7. Kirsch, W.M. , Gupta, S. and Zhu, Y.H. (2001). Sutureless Vascular Anastomosis: the VCS(R) clip , Cardiovascular Surgery, 9(6): 523–525 .

8. Hall, W.W. , Wrye, S.W. , Banducci, D.R. and Ehrlich, P. (2000). Microvascular Anastomosis Using 2-octyl Cyanoacrylate in the Rat Femoral Artery , Ann. Plast. Surg., 44(5): 508–511 .

9. Detweiler, M.B. , Verbo, A. , Kobos, J.W. , Durastante, V. and Pignoli, V. (1996). Gastrointestinal Sutureless Anastomosis Using Fibrin Glue: Reinforcement of the Sliding Absorbable Intraluminal Nontoxic Stent and Development of a Stent Placement Device , J. Invest. Surg., 9(2): 111–130 .

10.

10. Kamiji, T. , Eada, M. and Atsumoyo, K. (1989). Microvascular Anstomosis Using Polyethylene Glycol 4000 and Fibrin Glue , Br. J. Plast. Surg., 42: 54–58 .

11.

11. Moskovitz, M.J. , Bass, L. , Zhang, L. and Siebert, J.W. (1994). Microvascular Anastomoses Utilizing New Intravascular Stents , Ann. Plast. Surg., 32(6): 612–618 .

12.

12. Horton, D. and Just, E.K. (1973). Preparation From Chitin of (1–94)-2-Amino-2-deoxy-β-D-glucopyranuronan and its 2-Sulfoamino Analog Having Blood-anticoagulant Properties , Carbohydr. Res., 29: 173–179 .

13.

13. Wang, X.H. , Ma, J.B. , Feng, Q.L. and Cui, F.Z. (2003), The Effects of S-chitosan on the Physical Properties of Calcium Phosphate Cements , J. Bioactive and Compatible Polymer, 18: 45–57 .

14.

14. Wang, X.H. , Ma, J.B. , Feng, Q.L. and Cui, F.Z. (2003), In vivo Testing of S-chitosan Enhanced Calcium Phosphate Cements , J. Bioactive and Compatible Polymer, 18: 259–271 .

15.

15. Middleton, W.G. , Mattews, W. and Chiasson, D.A. (1991), Histoacryl Glue in Microvascular Surgery , J. Qtolaryngol., 20: 363–366 .

Anastomosis of Small Arteries Using a Soluble Stent and Bioglue

Abstract

Keywords

Get full access to this article

References