Dextran conjugates with nalidixic acid and oxacillin, were prepared in two ways: (a) by the reaction of the drugs with chloroacetylated crosslinked dextran microparticles and (b) by the reaction of the drugs with crosslinked polysaccharide microparticles in the presence of a coupling agent. The in vitro behavior of these conjugates was studied and the mechanism of drug release was determined.
Get full access to this article
View all access options for this article.
References
1.
1. H. Vermeersch, D. Vandome, E. Permentier and E. Schacht. 1985. Bull. Soc. Chim. Belge, 94, 591-596.
2.
2. G. Mocanu, A. Airinei and A. Carpov. 1993. J. Bioactive and Compatible Polymers, 8(4), 383-391.
3.
3. E. Harboe, M. Johansen and C. Larsen. 1988. Farm Sci. Ed., 16, 73-85.
4.
4. C. Larsen and M. Johansen. 1989. Acta Pharm. Nord, 2(1), 57-66.
5.
5. C. Larsen. 1989. Int. J. of Pharmaceutics, 52, 55-61.
6.
6. P. Ferruti, R. Paoletti and L. Puglisi. 1979. "Hauts polyméres contenant des radicaux de l'acide nicotinique liés à des matrices macromoléculaires de nature polysaccharidique, procédé pour leur préparation et leur utilisation," Fr. Pat. 2 346 016.
7.
7. G. Mocanu, A. Airinei and A. Carpov. 1994, STP Pharma Sci., 4(4), 287-291.
8.
8. V. A. Snehko and A. V. Rogovin. 1972. Antibiotiki, 17(1), 48-52.
9.
9. C. Larsen and M. Johansen. 1985. Arch. Pharm. Chem., 92, 809-931.
10.
10. Y. Manabe and T. Tsubota. 1984. J. Lab. Clin. Med., 104, 445-454.
11.
11. M. Mora and J. Pato. 1990. Makromol. Chem., 191, 1051-1056.
12.
12. M. Gosh. 1988. Progr. Biomed. Polym. [Proc. A. Chem. Soc. Symp.] (pub. 1990), 335-345.
13.
13. M. Ghosh. 1988. Polym. Mater. Sci., 59, 790-793.
14.
14. H. Bundgaard, N. Moerk and A. Hoelgaard. 1989. Int. J. of Pharmaceutics, 55(2-3), 91-97.
15.
15. F. Arranz and M. Sanchez-Chaves. 1995. Polym. Bull., 35(5), 533-537.
16.
16. S. Dumitriu and V. Blascu. 1995. J. Biomater. Appl., 9(3), 289-306.
17.
17. K. O. Muranov, A. Ya. Polishchuk, A. L. Iordanskii, G. E. Zaikov, B. P. Pashinin, T. N. Egorova and A. P. Masiyukov. 1990. Khim. Pharm. Zh., 24(9), 68-71.
18.
18. L. Tamasini, V. Andonova, M. Goshkaryan, V. Tomova and K. Popov. 1973. Farmatsiya (Sofia), 23(1), 19-23.
19.
19. A. Zaremba and L. Krowczynski. 1975. Acta Pol. Pharm., 32(1), 89-93.
20.
20. M. Macoveanu, Al. Tofan, A. Carpov, G. Mocanu and D. Mihai. 1990. "Process of the preparation of a stabilization agent for organic media," Rom. Pat. 102 878.
21.
21. G. Mocanu and A. Carpov. 1992. Cellulose Chem. and Technol., 6, 675-681.
22.
22. US Pharmacopea XXI Revision. 1985. US Pharmacopeal Convention Rockville, MD, 1420.
23.
23. Clarkes's Isolation and Identification of Drugs in Pharmaceuticals, Body Fluids and Post-Mortem Material, The Pharmaceutical Press, Second Ed., 1986, 160-220.
24.
24. J. C. Ramirez, M. Sanchez-Chaves and F. Arranz. 1994. Polymer, 35(12), 2651-2655.
25.
25. C. Larsen. 1989. Advanced Drug Delivery Reviews, 3, 103-154.
