Multifocal Embolic Strokes Following Cardiac Surgery in a Protein C-Deficient Child

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Silva CA : Neuroimaging of cerebral infarction associated with coronary revascularization . AJNR 1991;12:817-818.

Terplan KL : Brain changes in newborns, infants and children with congenital heart disease in association with cardiac surgery. Additional observations. J Neurol 1976;212:225-236.

Terplan KL : Patterns of brain damage in infants and children with congenital heart disease. Association with catheterization and surgical procedures. Am J Dis Child 1973;125:175-185.

Bellinger DC , Jonas RA , Rappaport LA , et al: Developmental and neurologic status of children after heart surgery with hypothermic circulatory arrest or low-flow cardio-pulmonary bypass. N Engl J Med 1995 ;332:549- .

Wyss M. , Babel JF , Rouge JC , Bouvier CA : Haemostatic changes during open heart surgery with extracorporeal circulation and deep hypothermia in children. Anaesthesist 1982;31:82-86.

Boldt J. , Knothe C. , Schindler E. : Thrombomodulin in pediatric cardiac surgery. Ann Thorac Surg 1994;57:1584-1589.

Esmon CT : Protein-C: Biochemistry, physiology, and clinical implications. Blood 1983;62:1155-1158.

Matsuda M. , Sugo T. , Sakata Y. , et al: A thrombotic state due to an abnormal protein C. N Engl J Med 1988;319:1265-1268.

Gandrille S. , Greengard JS , Ahenc-Galas I. , et al: Incidence of activated protein C resistance caused by the ARG 506 GLN mutation in factor V in 113 unrelated symptomatic protein C-deficient patients. Blood 1995;86:219-224.

10.

Martinez HR , Rangel-Guerra RA , Marfil LJ : Ischemic stroke due to deficiency of coagulation inhibitors. Report of 10 young adults. Stroke 1993;24:19-25.

11.

Uysal S. , Anlar B. , Altay C. , Kirazil S. : Role of protein C in childhood cerebrovascular occlusive accidents . Eur J Pediatr 1989;149:216-218.

12.

Pabinger I. , Brucker S. , Kyrle PA , et al: Hereditary deficiency of antithrombin III, protein C, and protein S: Prevalence in patients with a history of venous thrombosis and criteria for rational patient screening . Blood Coag Fibrinolysis 1992;3:547-553.

13.

Manco-Johnson MR , Marlar RA , Jacobson LJ , et al: Severe protein C deficiency in newborn infants. J Pediatr 1988;113:359-363.

14.

Manco-Johnson MR , Abshire TC , Jacobson LJ , Marlar RA : Severe neonatal protein C deficiency: Prevalence and thrombotic risk. J Pediatr 1991;119:793-798.

15.

Tarras S. , Gadia C. , Meister L. , et al: Homozygous protein C deficiency in a newborn clinicopathologic correlation. Arch Neurol 1988;45: 214-216.

16.

Israels SJ , Seshia SS : Childhood stroke associated with protein C or S deficiency. J Pediatr 1987;111:562-564.

17.

Dusser A. , Boyer-Neumann C. , Wolf M. : Temporary protein C deficiency associated with cerebral arterial thrombosis in childhood. J Pediatr 1988;113:849-851.

18.

Gould RJ , Black K. , Pavlakis SG : Neonatal cerebral arterial thrombosis: Protein C deficiency. J Child Neurol 1996;11:250-251.

19.

Pabinger I. , Kyrle PA , Heistinger M. , et al: The risk of thromboembolism in asymptomatic patients with protein C and protein S deficiency: A prospective cohort study . Thromb Hemost 1994;71;441-445.

20.

Nuss R. , Manco-Johnson M. , Hays T. : Childhood thrombosis. Pediatrics 1995 ;96:291-294.

21.

Vukovich T. , Auberger K. , Weil J. , et al: Replacement therapy for a homozygous protein C deficiency-state using a concentrate of human protein C and S. Br J Haematol 1988 ;70:435-440.

22.

Peters C. , Casella JF , Marlar RA , et al: Homozygous protein C deficiency: Observations on the nature of the molecular abnormality and the effectiveness of warfarin therapy. Pediatrics 1988;31:272-276.