Vigabatrin has been studied in adult drug-resistant epilepsy since 1982 in single-blind and double-blind studies followed by long-term, open evaluations. These studies have provided evidence that vigabatrin is a potent and well-tolerated antiepileptic drug and support its potential value in pediatric epilepsy. The lack of any evidence of human neurotoxicity in these patients is also reassuring regarding its use in children. (J Child Neurol 1991;6(Suppl):2525-2529).
Get full access to this article
View all access options for this article.
References
1.
Gram L., Lyon BB, Dam M.: Gamma-vinyl-GABA: A single blind trial in patients with epilepsy. Acta Neurol Scand1983;68:34-39.
2.
Schechter PJ , Hanke NFJ, Grove J., et al: Biochemical and clinical effects of gamma-vinyl-GABA in patients with epilepsy. Neurology1984;34:1823-1826.
3.
Browne TR, Mattson RH, Penry JK, et al: Vigabatrin for refractory complex partial seizures: Multicentre single blind study with long term follow-up. Neurology1987;37:184-189.
4.
Rimmer EM: Double blind study of γ-vinyl GABA in patients with refractory epilepsy . Lancet1984;1:189-190.
5.
Loiseau P., Hardenberg JP, Pestre M., et al: Double blind, placebo controlled study of vigabatrin (gamma-vinyl GABA) in drug resistant epilepsy. Epilepsia1986;27:115-120.
6.
Tassinari CA , Michelucci R., Ambrosetto G., Salvi F.: Double blind study of vigabatrin in the treatment of drug resistant epilepsy. Arch Neurol1987 ;44:907-910.
7.
Tartara A., Manni R., Galimberti CA, et al: Vigabatrin in the treatment of epilepsy: A double blind, placebo controlled study. Epilepsia1986;27:717-723.
8.
Remy C., Favel P., Tell G., et al: Etude en double aveugle contre placebo en permutations croisées du vigabatrin dans l'épilepsie de l'adulte résistant à la thérapeutique. Boll Lega Ital Epilepssia1986;54/55:241-243.
9.
Gram L., Klosterskov P., Dam M.: γ-Vinyl GABA: A double blind placebo controlled trial in partial epilepsy . Ann Neurol1985;17:262-266.
10.
Mumford JP, Dam M.: Meta-analysis of European placebo controlled studies of vigabatrin in drug resistant epilepsy. Br J Clin Pharmacol1989 ;27:101-107.
11.
Browne TR, Mattson RH, Penry JK, et al: A multicentre study of vigabatrin for drug resistant epilepsy . Br J Clin Pharmacol1989;27:95S-100S.
12.
Remy C., Beaumont D.: Efficacy and safety of vigabatrin in the long term treatment of refractory epilepsy. Br J Clin Pharmacol1989;27:125S-129S.
13.
Dam M.: Long term evaluation of vigabatrin (gamma vinyl GABA) in epilepsy . Epilepsia1989;30:26-30.
14.
Livingston JH, Beaumont D., Arzimanoglou A., Aicardi J.: Vigabatrin in the treatment of epilepsy in children. Br J Clin Pharmacol1989;27(Suppl 1):109S-112S.
15.
Luna D., Dulac O., Pajot N., Beaumont D.: Vigabatrin in the treatment of childhood epilepsies: A single-blind placebo-controlled study. Epilepsia1989;30:430-437.
16.
Chiron C., Dulac O., Luna D., et al: Vigabatrin in infantile spasms (letter). Lancet1990;335:363-364.
17.
Rey E., Pons G., Richard MO, et al: Pharmacokinetics of the individual enantiomers of vigabatrin (γ-vinyl GABA) in epileptic children. Br J Clin Pharmacol1990;30:253-257.
