We studied neonates with hyperosmolar syndrome using photo-evoked eyelid microvibration, a blink reflex elicited by photic stimuli. Patients with hyperosmolality showed disturbance of consciousness, convulsive seizures, hyperexcitability, and tachypnea. The latency of photo-evoked eyelid microvibration tended to be prolonged with an elevation of the plasma osmolality. Photo-evoked eyelid microvibration is believed to be a suitable method for monitoring brain disturbance due to hyperosmolality. (J Child Neurol 1990;5:191-194).
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References
1.
1. Yasuhara A., Sugimoto T., Naito H., et al: Effects of hyperosmolality on the central nervous system and intracranial hemorrhage. Brain Dev1982;4:353-360.
2.
2. Sugimoto T., Yasuhara A., Matsumura T: Intracranial hemorrhage following administration of sodium bicarbonate in rabbits. Brain Dev1981;3:297-303.
3.
3. Simmons MA, Adocock EW, Bard H., Battaglia FC: Hypernatremia and intracranial hemorrhage in neonates. N Engl J Med1974;291:6-10.
4.
4. Tachibana Y., Yasuhara A: Hyperosmolar syndrome and diffuse CNS dysfunction with clinical implications. Funct Neurol1986;1: 140-155.
5.
5. Yasuhara M., Naito H: Potential changes and eyelid microvibration elicited by flash stimulation . Int J Neurosci1982;17: 23-31.
6.
6. Yasuhara A., Yamada A., Matsumura T: Photo-evoked eyelid microvibration (blink reflex elicited by flash stimuli) in newborns and children. Brain Dev1983;5:474-477.
7.
7. Yasuhara A., Hori A., Sugimoto T., Iwase S., Kobayashi Y: Diagnostic/prognostic significance of photo-evoked eyelid microvibration in neonates with intracranial hemorrhage. Electroencephalogr Clin Neurophysiol1987;67:584-587.
8.
8. Arieff AI, Carroll HJ: Non-ketotic hyperosmolar coma with hyperglycemia: Clinical features, pathophysiology, renal function, acid base balance, plasma cerebrospinal fluid equilibria and the effects of therapy in 37 cases. Medicine1972;51:73-94.
9.
9. Gorden EE, Kabadi UM: The hyperglycemic hyperosmolar syndrome. Am J Med Sci1976;271:252-268.
