Histocompatibility Determinants in Childhood Postinfectious Encephalomyelitis

Abstract

Postinfectious encephalomyelitis and multiple sclerosis have clinical, immunologic, and neuroradiographic similarities. We studied HLA determinants in six white children consecutively diagnosed with postinfectious encephalomyelitis. Each of the children had HLA determinants which have been associated with multiple sclerosis. Relative risk (RR) calculations demonstrated that these antigens and genotypes occurred significantly more often in patients with postinfectious encephalomyelitis than in the control population (A3, RR 6.14; B7, RR 6.14; DR2, RR 4.51; A3B7, RR 9.36; A3DR2, RR 5.83; B7DR2, RR 6.13; A3B7DR2, RR 10.90). These data suggest that children with postinfectious encephalomyelitis are genetically predisposed to this demyelinating disease. Although the same HLA determinants were found in these patients as in those with multiple sclerosis, studies of a larger number of postinfectious encephalomyelitis patients will be needed before it can be concluded that the two diseases share a common genetic propensity. (J Child Neurol 1989;4:203-206).

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References

Kissmeyer-Nielson E. , Kjerbye KE : Purification of lymphocytes by flotation, in Terasaki P (ed): Histocompatibility Testing . Copenhagen, Munksgaard, 1967, pp 381-382.

Danilova J. , Ayoub G. , Terasaki P. : B-lymphocyte isolation by thrombin-nylon wool, in Terasaki P (ed): Histocompatibility Testing . Copenhagen, Munksgaard, 1980, pp 287.

Mann DL , Abelson L. , Henkart P. , et al: Specific human B lymphocyte alloantigens linked to HLA. Proc Natl Acad Sci USA 1975;73:5103-5106.

Svejgaard A. , Jersild C. , Staub-Nielson L. , et al: HLA-antigens and disease. Statistical and genetical considerations. Tissue Antigens 1974;4:95-105.

Woolf B. : On estimating the relation between blood group and disease. Ann Hum Genet 1955;19:251-253.

Tirawi JL , Terasaki PI : HLA and Disease Associations. New York, Springer-Verlag, 1985, p 19.

Pasternak JF , De Vivo DC , Prensky AL : Steroid-responsive encephalomyelitis in childhood . Neurology 1980;30:481-486.

Alter M. , Zhen-xin Z. , Davanipour Z. , et al: Multiple sclerosis and childhood infections. Neurology 1986;36:1386-1389.

Alvord ED , Jahnke U. , Fischer EH , et al: The multiple causes of multiple sclerosis: The importance of age of infections in childhood. J Child Neurol 1987;2:313-321.

10.

DiMario FJ , Berman PH : Multiple sclerosis presenting at 4 years of age: Clinical and MRI correlations . Clin Pediatr 1988;27: 32-37.

11.

Haslam R. : Multiple sclerosis: Experience at the Hospital for Sick Children. Int Pediatr 1987;2:163-167.

12.

Jersild C. , Dupont B. , Fog T. , et al: Histocompatibility determinants in multiple sclerosis. Transplant Rev 1975;22:148-163.

13.

Batchelor JR , Compston A. , Macdonald WI : The significance of the association between HLA and multiple sclerosis. Br Med Bull 1978 ;34:279-284.

14.

Spielman RS , Nathanson N. : The genetics of susceptibility to multiple sclerosis. Epidemiol Rev 1982;4:45-65.

15.

Sriram S. , Stewart M. , Buhler C. , et al: HLA-DR antigens in multiple sclerosis: Two-dimensional gel electrophoresis . Neurology 1985;35:248-251.

16.

Engell T. , Raun NE , Thomsen M. , Platz P. : HLA and heterogeneity of multiple sclerosis. Neurology 1982;32:1043-1046.

17.

Rodriguez M. , Leibowitz J. , David CS : Susceptibility to Theiler's virus-induced demyelination. Mapping of the gene within the H-2D region. J Exp Med 1986;163:620-631.

18.

Rodriguez M. , Lafuse, WP , Leibowitz , et al: Partial suppression of Theiler's virus-induced demyelination in vivo by administration of monoclonal antibodies to immune-response gene products (Ia antigens). Neurology 1986 ;36:964-970.

19.

Steinman LM , Smith ME , Forno LS : Genetic control of susceptibility to experimental allergic neuritis and the immune response to P2 protein. Neurology 1981;31:950-954.

20.

Gasser DL , Newlin CM , Palm J. , Gonatas NK : Genetic control of susceptibility to experimental allergic encephalomyelitis in rats. Science 1973;181:872-873.