Somatosensory evoked potentials (SSEPs) are a useful, reliable means of assessing function of the somatosensory system. Complex maturational changes of the CNS such as synaptogenesis and myelination, as well as body growth, complicate interpretation of SSEPs. An understanding of these factors enhances clinical interpretation in infants and children. (J Child Neurol 1989 ;4 :3-19).
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References
1.
Allison T. , Hume AL, Wood CC, et al: Developmental and aging changes in somatosensory, auditory, and visual evoked potentials . Electroencephalogr Clin Neurophysiol1984;58:14-24.
2.
Chiappa KH, Choi SK, Young RP: Short-latency somatosensory evoked potentials following median nerve stimulation in patients with neurological lesions, in Desmedt JE (ed): Clinical Uses of Cerebral, Brainstem, and Spinal Somatosensory Evoked Potentials, vol 7. Basel, Karger, 1980.
3.
Cullity P. , Franks CI, Duckworth T., et al: Somatosensory evoked cortical responses in normal infants. Dev Med Child Neurol1976 ;18:11-18.
4.
Desmedt JE, Brunko E., Debecker J.: Maturation of the somatosensory evoked potentials in normal infants and children with special reference to the early N1 component. Electroencephalogr Clin Neurophysiol1976;40:43-58.
5.
Hrbek A., Karlberg P., Olsson T.: Development of visual and somatosensory evoked responses in preterm newborn infants. Electroencephalogr Clin Neurophysiol1973;34:225-232.
6.
Gilmore RL, Bass NH, Wright EA, et al: Development assessment of spinal cord and cortical evoked potentials after tibial nerve stimulation: Effects of age and stature on normative data during childhood. Electroencephalogr Clin Neurophysiol1985;62: 241-251.
7.
Georgesco M. , Radiere M., Seror P., et al: Les potentiels cerebraux somesthesiques evoques a partir du membre inferieur chez le nouveau-ne le nourrisson. Rev EEGNeurophysiol1982; 12:123-128.
8.
Cracco JB, Cracco RQ, Stolove R.: Spinal evoked potentials in man: A maturational study. Electroencephalogr Clin Neurophysiol1979;46:58-64.
9.
Allison T.: Scalp and cortical recordings of initial somatosensory cortex activity to median nerve stimulation in man. Ann NY Acad Sci1982;388:671-678.
10.
Desmedt JE, Cheron G.: Somatosensory evoked potentials in man: Subcortical and cortical components and their neural basis. Ann NY Acad Sci1982 ;388:388-411.
11.
Emerson RG, Seyal M., Pedley TA: Somatosensory evoked potentials following median nerve stimulation . I. The cervical components. Brain1984 ;107:169-182.
12.
Leuders H., Lesser R., Hahn J., et al: Subcortical somatosensory evoked potentials to median nerve stimulation. Brain1983;106: 341-372.
13.
LorenteDe No RA: A study of nerve physiology. Studies from theRockefeller Institute1947;132:384-477.
14.
Kimura J., Mitsudome A., Yamada T., Dickins QS: Stationary peaks from a moving source in a far-field recording. Electroencephalogr Clin Neurophysiol1984;58:351-361.
15.
Leuders H., Dinner DS, Lesser RP, Klem G.: Origin of far-field evoked potentials to posterior tibial and median nerve stimulation. Arch Neurol1983;40:93-97.
16.
Desmedt JE, Nguyen TH, Carmeliet J.: Unexpected latency shifts of the stationary P9 somatosensory evoked potential far field with changes in shoulder position. Electroencephalogr Clin Neurophysiol1983;56:628-634.
17.
Anziska B., Cracco RQ: Short latency SEPs to median nerve stimulation: Comparison of recording methods and origin of components. Electroencephalogr Clin Neurophysiol1981;52: 531-539.
18.
Yamada T., Kimura J., Nitz DM: Short latency somatosensory evoked potentials following median nerve stimulation . Electroencephalogr Clin Neurophysiol1980 ;48:367-376.
19.
Yamada T., Kimura J., Wilkinson JT, Kayamori R.: Short- and long-latency median somatosensory evoked potentials: Findings in patients with localized neurological lesions. Arch Neurol1983;40:215-220.
20.
Cracco JB, Cracco RQ: Spinal, brainstem, and cerebral SEP in the pediatric age group, in Cracco RQ, Bodis-Wollner I (eds): Evoked Potentials. New York , Alan R. Liss, Inc, 1986 , pp 471-482.
21.
Desmedt JE, Cheron G.: Prevertebral (oesophageal) recording of subcortical somatosensory evoked potentials in man: The spinal P13 component and the dual nature of spinal generators . Electroencephalogr Clin Neurophysiol1981 ;52:257-275.
22.
Chiappa KH : Short-latency somatosensory evoked potentials: Methodology, in Evoked Potentials in Clinical Medicine. New York, Raven Press, 1983, pp 252-262.
23.
Goldie WD, Chiappa KH, Young RR, Brooks EB: Brainstem auditory and short-latency somatosensory evoked responses in brain death. Neurology1981;31:248-256.
24.
Desmedt JE, Cheron G.: Central somatosensory conduction in man: Neural generators and interpeak latencies of far-field components recorded from neck and right or left scalp and ear lobes. Electroencephalogr Clin Neurophysiol1980;50:382-403.
25.
Yamada T., Kayamori R., Kimura J., Beck DO: Topography of somatosensory evoked potentials after stimulation of the median nerve. Electroencephalogr Clin Neurophysiol1984;59: 29-43.
26.
Hume AL, Cant BR: Conduction time in central somatosensory pathway in man. Electroencephalogr Clin Neurophysiol1978;45: 361-375.
27.
Emerson RG, Pedley TA: Generator sources of median somatosensory evoked potentials. J Clin Neurophysiol1984;1:203-218.
28.
Kimura J., Yamada T., Kawamura H.: Central latencies of somatosensory cerebral evoked potential. Arch Neurol1978;35:683-688.
29.
Tsuji S., Shibasaki H., Kato M., et al: Subcortical, thalamic and cortical somatosensory evoked potentials to median nerve stimulation. Electromcephalogr Clin Neurophysiol1984;59:465-476.
30.
Yamada T., Ishida T., Kudo Y., et al: Clinical correlates of abnormal P14 in median SEPs. Neurology1986;36:765-771.
31.
Seyal M., Gabor AJ: The human posterior tibial somatosensory evoked potential: Synpase dependent and synapse independent spinal components. Electroencephalogr Clin Neurophysiol1985;62:323-331.
32.
Seyal M., Kraft LW, Gabor AJ: Cervical synapse-dependent somatosensory evoked potentials following posterior tibial nerve stimulation. Neurology1987;37:1417-1421.
33.
Cruse R., Klem G., Lesser RP, Lueders H.: Paradoxical lateralization of cortical potentials evoked by stimulation of posterior tibial nerve. Arch Neurol1982 ;39:222-225.
34.
Seyal M., Emerson RG, Pedley TA: Spinal and early scalp-recorded components of the somatosensory evoked potential following stimulation of the posterior tibial nerve. Electroencephalogr Clin Neurophysiol1983;55:320-330.
35.
Emerson RG : The anatomic and physiologic bases of posterior tibial nerve somatosensory evoked potentials, in Gilmore RG (ed): Evoked Potentials. Neurologic Clinics. Philadelphia , WB Saunders Co, in press.
36.
Penfield W. , Rasmussen T.: The cerebral cortex of man: A clinical study of localization of function . New York , MacMillan, 1950.
37.
Lesser PR, Lueders H., Dinner DS, et al: The source of 'paradoxical lateralization' of cortical evoked potentials to posterior tibial stimulation. Neurology1987;37:82-88.
38.
Willis J., Seales D., Frazier E.: Short latency somatosensory evoked potentials in infants. Electroencephalogr Clin Neurophysiol1984;59:366-373.
39.
Cracco J., Udani V., Cracco R.: MN-SSEPs in infants. Presented at the American EEG Society Scientific Session, St Louis, MO, Sept 17, 1987.
40.
Goldie WD, Spydell JD: Somatosensory evoked potentials following median nerve stimulation in infants: Normative and clinical studies. Presented at the American EEG Society Workshop, EPs in Children. St Louis, MO, Sept 18, 1987.
41.
Gilmore RL , Nelson KR: Electrodiagnosis in Guillain-Barré syndrome in children: Comparison of somatosensory evoked potentials and F-wave studies, abstract. Electroencephalogr Clin Neurophysiol , in press.
42.
American Electroencephalographic Society : Guidelines for clinical evoked potential studies . Clin Neurophysiol1984;1: 3-53.
43.
Simpson JA: Fact and fallacy in measurement of conduction velocity in motor nerves . J Neurol Neurosurg Psychiatry1964;27: 381-385.
44.
Young RR, Shahani BT: Clinical value and limitations of F wave determination. Muscle Nerve1978;1:248-250.
45.
Lastimosa ACB , Bass NH, Stanback K., et al: Lumbar spinal cord and early cortical evoked potentials after tibial nerve stimulation: Effects of stature on normative data. ElectroeneephalogrClin Neurophysiol1982;54:499-507.
46.
Gilmore RL, Brock J., Hermansen MC, et al: Development of lumbar spinal cord and cortical evoked potentials after tibial nerve stimulation in the pre-term newborns: Effects of gestational age and other factors. Electroencephalogr Clin Neurophysiol1987;68:28-39.
47.
Ouvrier RA, McLeod JG, Conchin T.: Morphometric studies of sural nerve in childhood. Muscle Nerve1987;10:47-53.
48.
Hildebrand C., Skoglund S.: Caliber spectra of some fiber tracts in the feline central nervous system during postnatal development. Acta Physiol Scand1971;364:5-41.
49.
Merlob P., Sivan Y., Reisner SH: Lower limb standards in newborns. Am J Dis Child1984;138:140-142.
50.
Dubowitz V. , Whittaker GF, Brown BH, et al: Nerve conduction velocity: An index of neurological maturity of the newborn infant. Dev Med Child Neurol1968;10:741-749.
51.
Schulte FJ, Michaelis R., Linke I., et al: Motor nerve conduction velocity for term, preterm and small-for-dates newborn infants. Pediatrics1968;42:17-26.
52.
Wagner AL, Buchthal F.: Motor and sensory conduction in infancy and childhood: Reappraisal . Dev Med Child Neurol1972;14:189-216.
53.
Buchthal F. , Rosenfalck A., Behse F.: Sensory potentials of normal and diseased nerves, in Dyck PJ, Thomas PK , Lambert EH (eds): Peripheral Neuropathy . Philadelphia , WB Saunders Co , 1975 , pp 442-464.
54.
Barson AJ: The vertebral level of termination of the spinal cord during normal and abnormal development. J Anat1970;106: 489-497.
55.
Yakovlev P. , Lecours A.: The myelogenetic cycles of regional maturation of the brain, in Minkowski A (ed): Regional Development of the Brain in Early Life. Philadelphia, FADavis Co, 1967 , pp 3-69.
56.
Hughes AF: The development of the dorsal funiculus in the human spinal cord. J Anat1976;122:169-175.
57.
Dobbing J., Smart JL: Vulnerability of developing brain and behavior. Br Med Bull1974;30:164-168.
58.
Ferrington DG, Rowe MJ: Functional capacities of tactile afferent fibers in neonatal kittens. J Physiol ( Lond) 1980;307:335-353.
59.
Rowe MJ: Development of mammalian somatosensory pathways. Trends Neurosci1982;5:408-411.
60.
Rorke LB, Riggs HE: Myelination of the Brain in the Newborn. Philadelphia, JB Lippincott Co, 1969, pp 15,18, 21, 23.
61.
Gilles FH, Shankle EC, Dooling EC: Myelinated tracts: Growth patterns, in Gilles FH, Leviton A, Dooling EC (eds): The Developing Human Brain . Boston, John Wright, 1983, pp 117-183.
62.
Gallai V.: Maturation of SEPs in pre-term and full-term neonates, in Gallai V (ed): Maturation of the CNS and Evoked Potentials. Amsterdam, Elsevier , 1987, pp 95-106.
63.
Hashimoto T. , Tayanama M., Hiura K., et al: Short latency somatosensory evoked potentials in children. Brain Dev1983;4: 390-396.
64.
Desmedt JE, Manil J.: Somatosensory evoked potentials of the normal human neonate in REM sleep, in slow wave sleep and in waking. Electroencephalogr Clin Neurophysiol1970;29:113-126.
65.
Gilmore RL : Effects of sleep on central conduction time in infants and children . Presented at the International EEG Congress Scientific Session . London , August, 1985.
66.
Gilmore RL, Hermansen M., Brock J., et al: Effect of sleep on cortical SSEP: Age dependency during growth and development, abstract. Electroencephalogr Clin Neurophysiol1986;64:42P.
67.
Roy MW, Gilmore R., Walsh JW: Somatosensory evoked potentials in tethered cord syndrome, abstract . Electroencephalogr Clin Neurophysiol1986 ;64:42P.
68.
Frank LM, Furgiuele TL, Etheridge JE: Prediction of chronic vegetative state in children using evoked potentials . Neurology1985;35:931-934.
69.
White LE, Frank LM, Furguide TL, et al: Prognostic value of BAEP with near- and far-field SSEP in childhood coma. Neurology1985;35(Suppl 1):199.
70.
Lutschg J., Pfenninger J., Ludin HP, et al: Brainstem auditory evoked potentials and early somatosensory evoked potentials in neurointensively treated comatose children. Am J Dis Child1983;137:421-426.
71.
Goldie W., McMahon A.: The combined use of BAEPs and SSEPs in the assessment of brainstem dysfunction in children. Electroencephalogr Clin Neurophysiol1983;56:35.
72.
Gilmore RL, Lastimosa ACL: Determination of site and extent of brainstem gliomas using BAEPs and SSEPs . Electroencephalogr Clin Neurophysiol1983 ;56:5P.
73.
De Meirleir LJ, Taylor MJ: The prognostic utility of SEPs in comatose children. Pediatr Neurol1987;3:78-82.
74.
Goff WR, Shaywitz BA, Goff GD, et al: Somatic evoked potential evaluation of cerebral status in Reye syndrome. Electroencephalogr Clin Neurophysiol1983;55:388-398.
75.
Udani V. , Cracco JB, Hittelman J., et al: Clinical and developmental evaluation, evoked potentials and MRI in pediatric AIDS. Presented at the American EEG Society Scientific Session. St Louis MO, September 18, 1987.
76.
Salamy A., Davis S., Eldredge L., et al: Neonatal status: An objective scoring method for identifying infants at risk for poor outcome. Early Hum Dev, in press.
77.
Hrbek A., Karlberg P., Kjellmer I., et al: Clinical application of evoked electroencephalographic responses in newborn infants. I: Perinatal asphyxia. Dev Med Child Neurol1977;19:34-44.
78.
Laget P., Salbreux R., Raimbault J., et al: Relationship between changes in somesthetic evoked responses and electroencephalographic findings in the child with hemiplegia. Dev Med Child Neurol1976;18:620-631.
79.
Lutschg J., Hanggeli C., Huber P.: The evolution of cerebral hemispheric lesions due to pre- or perinatal asphyxia (clinical and neuroradiological correlation). Helv Paediatr Acta1983;38: 245-254.
80.
Gorke W.: Somatosensory evoked cortical potentials indicating impaired motor development in infancy. Dev Med Child Neurol1986;28:633-641.
81.
Majnemer A. , Rosenblatt B., Riley P., et al: Somatosensory evoked response abnormalities in high-risk newborns . Pediatr Neurol1987 ;3:350-355.
82.
Markand O., DeMyer W., Worth R., et al: Multi-modality evoked responses in leukodystrophies, in Courjon J, Mauguiere F, Revol M (eds): Clinical Applications of Evoked Potentials in Neurology, Advances in Neurology , Vol 32. New York , Raven Press, 1982, pp 409-416.
83.
Cracco JB , Bosch VV, Cracco RQ: Cerebral and spinal somatosensory evoked potentials in children with CNS degenerative disease . Electroencephalogr Clin Neurophysiol1980;49:437-445.
84.
Tobimatsu S. , Fukui R., Kato M., et al: Multimodality evoked potentials in patients and carriers with adrenoleukodystrophy and adrenomyeloneuropathy . Electroencephalogr Clin Neurophysiol1985 ;62:18-24.
85.
Garg BP, Markand ON, DeMyer WE, et al: Evoked response studies in patients with adrenoleukodystrophy and heterozygous relatives. Arch Neurol1983 ;40:356-359.
86.
Rossini PM , Zarola F., Di Capu M., et al: Somatosensory evoked potentials in neurodegenerative system disorders, in Gallai V (ed): Maturation of the CNS and Evoked Potentials. Amsterdam , Elsevier, 1987.
87.
Taylor MJ, Chan-Lui WY, Logan WJ: Longitudinal evoked potential studies in hereditary ataxias. Can J Neurol Sci1985;12: 100-105.
88.
Nelson FW, Goldie WD, Hecht JT, et al: Short-latency somatosensory evoked potentials in the management of patients with achondroplasia. Neurology1984;34:1053-1058.
89.
Perot PL, Vera CL: Scalp recorded somatosensory evoked potentials to stimulation of nerves in the lower extremity in the evaluation of patients with spinal cord trauma . Ann NY Acad Sci1982;388:359-363.
90.
Cracco JB, Cracco RQ: Spinal somatosensory evoked potentials: Maturational and clinical studies . Ann NY Acad Sci1982;388: 526-537.
91.
Yamada S., Zinke DE, Sanders D.: Pathophysiology of "tethered cord syndrome." J Neurosurg1981;54:494-503.
92.
Kang JK, Kim MC, Kim DS, Song JU: Effects of tethering on regional spinal cord blood flow and sensory-evoked potentials in growing cats. Childs Nerv Syst1987;3:35-39.
93.
Rotteveel JJ , Colon EJ, Hombergen G., et al: The application of evoked potentials in the diagnosis and follow-up of children with intracranial tumors. Childs Nerv Syst1985;1:172-178.
94.
Fagan ER, Taylor MJ, Logan WJ: Somatosensory evoked potentials: Part II. A review of the clinical applications in pediatric neurology. Pediatr Neurol1987 ;3:249-255.
95.
Schiff J., Cracco RQ, Rossini PM, et al: Spine and scalp somatosensory evoked potentials in normal subjects and patients with spinal cord disease: Evaluation of afferent transmission . Electroencephalogr Clin Neurophysiol1984 ;59:374-387.
96.
Nelson KR, Gilmore RL, Massey A.: Acoustic nerve conduction abnormalities in Guillain-Barré syndrome . Neurology1988;38: 1263-1266.
97.
Gilmore RL, Nelson KR: Electrodiagnosis in Guillian-Barré syndrome: Comparison of somatosensory evoked potentials and F-wave studies. Muscle Nerve, in press.
