We present two children with seizures and other signs of cerebral involvement at the outset of acute inflammatory demyelinating polyneuropathy, consistent with a diagnosis of encephalomyeloradiculoneuropathy. One child had a recurrence associated with mild central dysfunction and improved during therapy with corticosteroids. Both children recovered completely. Both acute and relapsing inflammatory demyelinating neuropathy may be accompanied by cerebral dysfunction, expanding the clinical spectrum of encephalomyeloradiculoneuropathy. ( Child Neurol 1988;3:200-204).
Get full access to this article
View all access options for this article.
References
1.
Arnason BGW: Acute inflammatory demyelinating polyradiculoneuropathies, in Dyck PJ, Thomas PK , Lambert EH, Bunge R (eds): Peripheral Neuropathy vol. II. Philadelphia, WB Saunders, 1984, pp 2050-2114.
2.
Paulson GW: The Landry-Guillain-Barré-Strohl syndrome in childhood. Develop Med Child Neurol1970;12:604-607.
3.
Weiderholt WC , Mulder DW, Lambert EH: The Landry-Guillain-Barré syndrome or polyradiculoneuropathy: Historical review, report on 97 patients, and present concepts. Mayo Clin Proc1964 ;39:427-451.
4.
Gamstorp I.: Encephalomyeloradiculoneuropathy: Involvement of the CNS in children with Guillain-Barré-Strohl syndrome. Develop Med Child Neurol1974;16:654-658.
Campistol J. , Grandas F., Artigas J., et al: Sindrome de Guillain-Barré asociado a lesión cerebral hemisférica. Med Clin ( Barc) 1985;84:408-410.
7.
Blennow G., Gamstorp I., Rosenberg R.: Encephalomyeloradiculoneuropathy. Develop Med Child Neurol1968;10:485-490.
8.
Amit R., Shapira Y., Blank A., Aker M.: Acute, severe, central and peripheral nervous system combined demyelination . Pediatr Neurol1986;2:47-50.
9.
Miller RG, Peterson C., Rosenberg NL: Electrophysiologic evidence of severe distal nerve segment pathology in the Guillain-Barré syndrome. Muscle and Nerve1987;10:524-529.
10.
Rubin M., Karpati G., Carpenter S.: Combined central and peripheral myelinopathy. Neurology1987;37:1287-1290.
11.
Mendell JR, Kolkin S., Kissel JT, et al: Evidence for central nervous system demyelination in chronic inflammatory demyelinating polyradiculoneuropathy. Neurology1987;37:1291-1294.
12.
Thomas PK, Walker RWH, Rudge P., et al: Chronic demyelinating peripheral neuropathy associated with multifocal central nervous system demyelination. Brain1987;110:53-76.
13.
Best PV: Acute polyradiculoneuritis associated with demyelinated plaques in the central nervous system. Acta Neuropathol ( Berl ) 1985;67:230-234.
14.
Lassmann H. , Budka H., Schnaberth G.: Inflammatory demyelinating polyradiculitis in a patient with multiple sclerosis. Arch Neurol1981;38:99-102.
15.
Lonnum A.: Guillain-Barré syndrome with prominent spinal and cerebral phenomena . Acta Psychiat Neurol Scand1956;31: 261-271.
16.
Graux P., Milbled G., Petit H.: Syndrome de Guillain et Barré compliqué de mouvements choréiques et athétosiques . Rev Neurol(Paris) 1959 ;101:175-177.
17.
Pasternak JF , Fulling K., Nelson J., Prensky AL: An infant with chronic, relapsing polyneuropathy responsive to steroids. Dev Med Child Neurol1982;24:504-509.
18.
Whitaker JN : The protein antigens of peripheral nerve myelin . Ann Neurol1980;9(suppl):56-64.
19.
Lukes SA, Norman D.: Computed tomography in acute disseminated encephalomyelitis. Ann Neurol1983;13:567-572.
20.
Dal Canto MC , Rabinovitz SG: Experimental models of virus-induced demyelination of the central nervous system. Ann Neurol1982;11:109-127.
