Lacosamide in Lennox-Gastaut Syndrome? Caution Is Still Needed

Miskin C Khurana DS Valencia I Legido A Hasbani DM Carvalho KS . Efficacy and tolerability of lacosamide in the treatment of children with refractory generalized epilepsy. J Child Neurol. 2016;31(7):925–928.

Crespel A Gelisse P Nikanorova M Ferlazzo E Genton P . Lennox-Gastaut syndrome. In: Epileptic Syndromes in Infancy, Childhood and Adolescents. 5th edition. John Libbey Eurotext, 2012;189–216.

Arzimanoglou French J Blume WT . Lennox-Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology. Lancet Neurol. 2009;8(1):82–93.

Ferlazzo E Nikanorova M Italiano D . Lennox-Gastaut syndrome in adulthood: clinical and EEG features. Epilepsy Res. 2010;89(2-3):271–277.

Cuzzola A Ferlazzo E Italiano D Calabrò RS Bramanti P Genton P . Does lacosamide aggravate Lennox-Gastaut syndrome? Report on three consecutive cases. Epilepsy Behav. 2010;19(4):650–651.

Andrade-Machado R Luque-Navarro-de Los Reyes J Benjumea-Cuartas V . Efficacy and tolerability of add-on lacosamide treatment in adults with Lennox-Gastaut syndrome: an observational study. Seizure. 2015;33:81–87.

Italiano D Aguglia U Ferlazzo E . Use of lacosamide in Lennox-Gastaut syndrome: is it too premature? Acta Neurol Scand. 2014;130(2):e37–e38.